Department of Pharmacotherapy and Outcome Science,
School of Pharmacy
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Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice.
Journal of cardiovascular pharmacology Dec, 2010 | Pubmed ID: 20881611
Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
PloS one Mar, 2011 | Pubmed ID: 21455304
Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy.
Circulation. Arrhythmia and electrophysiology Aug, 2011 | Pubmed ID: 21576277
Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury.
Journal of molecular and cellular cardiology Aug, 2011 | Pubmed ID: 21600901
Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase.
Molecular medicine (Cambridge, Mass.) Sep-Oct, 2011 | Pubmed ID: 21637911
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22106299
Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse.
PloS one , 2011 | Pubmed ID: 22140485
A mouse model of radiation-induced cardiomyopathy.
International journal of cardiology Apr, 2012 | Pubmed ID: 22340985
Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure.
PloS one , 2012 | Pubmed ID: 22438931
Recombinant human interleukin-1 receptor antagonist provides cardioprotection during myocardial ischemia reperfusion in the mouse.
Cardiovascular drugs and therapy Jun, 2012 | Pubmed ID: 22527620
GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse.
The Journal of pharmacology and experimental therapeutics Dec, 2012 | Pubmed ID: 22923737
Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse.
Experimental physiology Mar, 2013 | Pubmed ID: 23180808
Inhibition of apoptosis signal-regulating kinase 1 reduces myocardial ischemia-reperfusion injury in the mouse.
Journal of the American Heart Association Oct, 2012 | Pubmed ID: 23316291
Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse.
PloS one , 2013 | Pubmed ID: 23516478
Targeting interleukin-1 in heart disease.
Circulation Oct, 2013 | Pubmed ID: 24146121
A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse.
Journal of cardiovascular pharmacology Apr, 2014 | Pubmed ID: 24336017
Formation of the inflammasome in acute myocarditis.
International journal of cardiology Feb, 2014 | Pubmed ID: 24439778
Interleukin-18 mediates interleukin-1-induced cardiac dysfunction.
American journal of physiology. Heart and circulatory physiology Apr, 2014 | Pubmed ID: 24531812
Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure.
Molecular medicine (Cambridge, Mass.) Jun, 2014 | Pubmed ID: 24804827
Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice.
Circulation. Cardiovascular genetics Jun, 2014 | Pubmed ID: 24825878
Letter by Mezzaroma, et al regarding article, "NLRP3 inflammasome as a therapeutic target in myocardial infarction".
International heart journal , 2014 | Pubmed ID: 24942779
Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse.
Journal of cardiovascular pharmacology Jul, 2014 | Pubmed ID: 25006675
Response to letter regarding article, "targeting interleukin-1 in heart disease".
Circulation Aug, 2014 | Pubmed ID: 25114193
The inflammasome in myocardial injury and cardiac remodeling.
Antioxidants & redox signaling May, 2015 | Pubmed ID: 25330141
Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.
Cardiovascular research Feb, 2015 | Pubmed ID: 25524927
Effects of dimethyl sulfoxide on the NLRP3 inflammasome.
Immunobiology Aug, 2015 | Pubmed ID: 25743943
Role of Interleukin-1 in Radiation-Induced Cardiomyopathy.
Molecular medicine (Cambridge, Mass.) Mar, 2015 | Pubmed ID: 25822795
Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse.
Journal of cardiovascular pharmacology Jul, 2015 | Pubmed ID: 25915511
A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice.
International journal of cardiology Nov, 2015 | Pubmed ID: 26151718
A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II.
American journal of physiology. Heart and circulatory physiology Sep, 2015 | Pubmed ID: 26188021
Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse.
International journal of cardiology Apr, 2016 | Pubmed ID: 26896627
Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition.
Journal of cardiovascular pharmacology Jul, 2016 | Pubmed ID: 26945157
Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death.
International journal of molecular sciences Jun, 2016 | Pubmed ID: 27322252
Biomarkers of cardiac injury in patients undergoing thoracic radiation therapy.
International journal of cardiology Nov, 2016 | Pubmed ID: 27552565
IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects.
Radiation research Nov, 2016 | Pubmed ID: 27841740
A Preclinical Translational Study of the Cardioprotective Effects of Plasma-Derived Alpha-1 Anti-trypsin in Acute Myocardial Infarction.
Journal of cardiovascular pharmacology May, 2017 | Pubmed ID: 28195949
Reduction of Myocardial Ischemia-Reperfusion Injury by Inhibiting Interleukin-1 Alpha.
Journal of cardiovascular pharmacology Mar, 2017 | Pubmed ID: 28267688
Dietary Fat, Sugar Consumption, and Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction.
JACC. Basic to translational science Oct, 2017 | Pubmed ID: 30062167
Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction.
JACC. Basic to translational science Oct, 2017 | Pubmed ID: 30062170
An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet-Induced Cardiac Dysfunction in Mice.
Journal of cardiovascular pharmacology 12, 2018 | Pubmed ID: 30422890
The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse.
Journal of cardiovascular pharmacology 04, 2019 | Pubmed ID: 30747785
NLRP3 Inflammasome in Acute Myocardial Infarction.
Journal of cardiovascular pharmacology 09, 2019 | Pubmed ID: 31356555
Determinants of Cardiorespiratory Fitness Following Thoracic Radiotherapy in Lung or Breast Cancer Survivors.
The American journal of cardiology 03, 2020 | Pubmed ID: 31928717
Targeting the NLRP3 inflammasome to reduce warm ischemic injury in donation after circulatory death heart.
Clinical transplantation 10, 2020 | Pubmed ID: 32654189
Modulation of Interleukin-1 and -18 Mediated Injury in Donation after Circulatory Death Mouse Hearts.
The Journal of surgical research 01, 2021 | Pubmed ID: 32896815
The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches.
JACC. Basic to translational science Feb, 2021 | Pubmed ID: 33665514
NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases.
Molecules (Basel, Switzerland) Feb, 2021 | Pubmed ID: 33673188
Mitigation of Radiation-Induced Lung and Heart Injuries in Mice by Oral Sepiapterin after Irradiation.
Radiation research 05, 2021 | Pubmed ID: 33822229
Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177 (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction.
Molecules (Basel, Switzerland) Jun, 2021 | Pubmed ID: 34207886
Refining murine heterotopic heart transplantation: A model to study ischemia and reperfusion injury in donation after circulatory death hearts.
Animal models and experimental medicine 09, 2021 | Pubmed ID: 34557655
Improving circulatory death donor heart function: A novel approach.
JTCVS techniques Oct, 2021 | Pubmed ID: 34647070
Targeting the NLRP3 inflammasome in cardiovascular diseases.
Pharmacology & therapeutics Dec, 2021 | Pubmed ID: 34906598
The inflammasome in heart failure.
Current opinion in physiology Feb, 2021 | Pubmed ID: 34917871
The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
Cytokine 03, 2022 | Pubmed ID: 35091314
Assessment of machine perfusion conditions for the donation after circulatory death heart preservation.
Artificial organs Feb, 2022 | Pubmed ID: 35167122
Mohammed Quader1,2,3,
Renee Cholyway1,
Oluwatoyin Akande1,
Jennifer Bradley1,2,
Eleonora Mezzaroma4,
Stefano Toldo2,5
1Division of Cardiothoracic Surgery, Department of Surgery, Virginia Commonwealth University,
2Pauley Heart Center, Virginia Commonwealth University Health System,
3Department of Surgery, McGuire Veterans Administration Medical Center,
4Department of Pharmacotherapy and Outcome Science, School of Pharmacy, Virginia Commonwealth University,
5Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University
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