Jonathan V. Sweedler

Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign

Affiliated withUniversity of Illinois Urbana-Champaign

Research Area

ChemistryNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2022
Publication title	2025
Publication title	2025

Other Publications

Article	Year
Two toxins from Conus striatus that individually induce tetanic paralysis. Biochemistry\| PubMed ID: 17115716	2006
Targeted single-cell microchemical analysis: MS-based peptidomics of individual paraformaldehyde-fixed and immunolabeled neurons. Chemistry & biology\| PubMed ID: 22921068	2012
Evaluation of database search programs for accurate detection of neuropeptides in tandem mass spectrometry experiments. Journal of proteome research\| PubMed ID: 23082934	2012
Multifactorial Understanding of Ion Abundance in Tandem Mass Spectrometry Experiments. Journal of proteomics & bioinformatics\| PubMed ID: 24031159	2013
The ctenophore genome and the evolutionary origins of neural systems. Nature\| PubMed ID: 24847885	2014
Analysis of endogenous nucleotides by single cell capillary electrophoresis-mass spectrometry. The Analyst\| PubMed ID: 25212237	2014
Identification of best indicators of peptide-spectrum match using a permutation resampling approach. Journal of bioinformatics and computational biology\| PubMed ID: 25362838	2014
Mass spectrometry-based characterization of endogenous peptides and metabolites in small volume samples. Biochimica et biophysica acta\| PubMed ID: 25617659	2015
Peptidomics for the discovery and characterization of neuropeptides and hormones. Trends in pharmacological sciences\| PubMed ID: 26143240	2015
Peptidomics and Secretomics of the Mammalian Peripheral Sensory-Motor System. Journal of the American Society for Mass Spectrometry\| PubMed ID: 26392278	2015
Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea. The Journal of biological chemistry\| PubMed ID: 26884331	2016
A one-step matrix application method for MALDI mass spectrometry imaging of bacterial colony biofilms. Journal of mass spectrometry : JMS\| PubMed ID: 27476992	2016
Dopamine-modified TiO monolith-assisted LDI MS imaging for simultaneous localization of small metabolites and lipids in mouse brain tissue with enhanced detection selectivity and sensitivity... Chemical science\| PubMed ID: 28553535	2017
microMS: A Python Platform for Image-Guided Mass Spectrometry Profiling. Journal of the American Society for Mass Spectrometry\| PubMed ID: 28593377	2017
3D-Printed pHEMA Materials for Topographical and Biochemical Modulation of Dorsal Root Ganglion Cell Response. ACS applied materials & interfaces\| PubMed ID: 28813592	2017
Improved identification and quantitation of mature endogenous peptides in the rodent hypothalamus using a rapid conductive sample heating system. The Analyst\| PubMed ID: 29098220	2017
Bioinformatics for Prohormone and Neuropeptide Discovery. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29476505	2018
Non-targeted Identification of D-Amino Acid-Containing Peptides Through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29476507	2018
Peptide identifications and false discovery rates using different mass spectrometry platforms. Talanta\| PubMed ID: 29501178	2018
Exploring the Sea Urchin Neuropeptide Landscape by Mass Spectrometry. Journal of the American Society for Mass Spectrometry\| PubMed ID: 29667164	2018
Conformational investigation of the structure-activity relationship of GdFFD and its analogues on an achatin-like neuropeptide receptor of Aplysia californica involved in the feeding circuit... Physical chemistry chemical physics : PCCP\| PubMed ID: 30112548	2018
Aplysia allatotropin-related peptide and its newly identified d-amino acid-containing epimer both activate a receptor and a neuronal target. The Journal of biological chemistry\| PubMed ID: 30194283	2018
Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel. PloS one\| PubMed ID: 31211771	2019
Enhanced single-cell metabolomics by capillary electrophoresis electrospray ionization-mass spectrometry with field amplified sample injection. Analytica chimica acta\| PubMed ID: 32418602	2020
d-Alanine: Distribution, origin, physiological relevance, and implications in disease. Biochimica et biophysica acta. Proteins and proteomics\| PubMed ID: 32640293	2020
Advancing d-amino acid-containing peptide discovery in the metazoan. Biochimica et biophysica acta. Proteins and proteomics\| PubMed ID: 33002629	2021
Image-guided MALDI mass spectrometry for high-throughput single-organelle characterization. Nature methods\| PubMed ID: 34594032	2021
Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform. Lab on a chip\| PubMed ID: 34897344	2021
Droplet Microfluidics with MALDI-MS Detection: The Effects of Oil Phases in GABA Analysis. ACS measurement science Au\| PubMed ID: 34939077	2021
Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs. Frontiers in physiology\| PubMed ID: 35002782	2021
Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation. Annual review of analytical chemistry (Palo Alto, Calif.)\| PubMed ID: 35324254	2022
Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks. Advanced biosystems\| PubMed ID: 29552634	2017
Metabolomics-based mass spectrometry methods to analyze the chemical content of 3D organoid models. The Analyst\| PubMed ID: 35660810	2022
Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics. Pharmacological reviews\| PubMed ID: 35710134	2022
Profiling of d-alanine production by the microbial isolates of rat gut microbiota. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 35816159	2022
Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles. The Journal of biological chemistry\| PubMed ID: 35835221	2022
d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans. Metabolites\| PubMed ID: 36144204	2022
Attomole-Level Multiplexed Detection of Neurochemicals in Picoliter Droplets by On-Chip Nanoelectrospray Ionization Coupled to Mass Spectrometry. Analytical chemistry\| PubMed ID: 36166829	2022
Single cell metabolism: current and future trends. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 36181583	2022
Chemical Decrosslinking-Based Peptide Characterization of Formaldehyde-Fixed Rat Pancreas Using Fluorescence-Guided Single-Cell Mass Spectrometry. Analytical chemistry\| PubMed ID: 37040477	2023
MALDI-MS screening of microbial colonies with isomer resolution to select fatty acid desaturase variants. Analytical biochemistry\| PubMed ID: 37146955	2023
Integrative Multiscale Biochemical Mapping of the Brain via Deep-Learning-Enhanced High-Throughput Mass Spectrometry. bioRxiv : the preprint server for biology\| PubMed ID: 37398021	2023
Biodistribution and racemization of gut-absorbed L/D-alanine in germ-free mice. Communications biology\| PubMed ID: 37587187	2023
Relations between Glucose and d-Amino Acids in the Modulation of Biochemical and Functional Properties of Rodent Islets of Langerhans. ACS omega\| PubMed ID: 38144114	2023
Metabolic insights from mass spectrometry imaging of biofilms: A perspective from model microorganisms. Methods (San Diego, Calif.)\| PubMed ID: 38295894	2024
Multiscale biochemical mapping of the brain through deep-learning-enhanced high-throughput mass spectrometry. Nature methods\| PubMed ID: 38366241	2024
Bioinformatics for Prohormone and Neuropeptide Discovery. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 38549013	2024
Nontargeted Identification of D-Amino Acid-Containing Peptides Through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 38549017	2024
High-resolution H-MRSI at 9.4 T by integrating relaxation enhancement and subspace imaging. NMR in biomedicine\| PubMed ID: 38715469	2024
A novel series of metazoan L/D peptide isomerases. The Journal of biological chemistry\| PubMed ID: 38857862	2024
1-Octanol-assisted ultra-small volume droplet microfluidics with nanoelectrospray ionization mass spectrometry. Analytica chimica acta\| PubMed ID: 39155094	2024
Novel repurposing of sulfasalazine for the treatment of adrenocortical carcinomas, probably through the SLC7A11/xCT-hsa-miR-92a-3p-OIP5-AS1 network pathway. Surgery\| PubMed ID: 39424480	2025
Neurochemical and Morphological Comparisons of Motor Nerve Organoids and Spinal-Cord Explants. ACS chemical neuroscience\| PubMed ID: 39692746	2025
Enhancing lipid production in plant cells through automated high-throughput genome engineering and phenotyping. The Plant cell\| PubMed ID: 39899469	2025
Isoaspartate-containing galanin in rat hypothalamus. Communications chemistry\| PubMed ID: 40057589	2025
Factorial-Design-Based Optimization of a Commercial MALDI-2 timsTOF Mass Spectrometer for Lipid Analysis. Journal of the American Society for Mass Spectrometry\| PubMed ID: 40155311	2025
Bacterial biofilm sample preparation for spatial metabolomics. The Analyst\| PubMed ID: 40625053	2025
D-Amino acids affect Pseudomonas aeruginosa biofilm and quorum sensing molecules in lung infection models developed under a cystic fibrosis environment. Scientific reports\| PubMed ID: 40653503	2025
High-Throughput Fluorescence-Guided Sequential Single-Cell MALDI-ICC Mass Spectrometry. Analytical chemistry\| PubMed ID: 40689559	2025