Masato Koike

Autophagic neuron death.

Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains.

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.

Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice.

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.

Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6.

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.

Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system.

Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading.

Exendin-4 improves β-cell function in autophagy-deficient β-cells.

Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells.

Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.

NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization.

Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.

Increased immunoreactivity of cathepsins in the rat esophagus under chronic acid reflux esophagitis.

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.

L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain.

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition.

Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy.

Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis.

Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein.

Cellular localization and tissue distribution of endogenous DFCP1 protein.

VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.

Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.

Human Herpesvirus 6A U14 Is Important for Virus Maturation.

Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD.

Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation.

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.

Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.

Suppression of Ischemia-Induced Hippocampal Pyramidal Neuron Death by Hyaluronan Tetrasaccharide through Inhibition of Toll-Like Receptor 2 Signaling Pathway.

Morphological process of podocyte development revealed by block-face scanning electron microscopy.

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.

Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS.

Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain.

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.

Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.

TDP-43 accelerates age-dependent degeneration of interneurons.

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.

Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes.

Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator.

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.

Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage.

GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease.

Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.

Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis.

Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface.

Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture.

Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.

Oxytocin induced labor causes region and sex-specific transient oligodendrocyte cell death in neonatal mouse brain.

α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.

Insulin2 (Kuma) mutant mice develop diabetes with dominant inheritance.

Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson's Disease.

Unique synaptic topography of crest-type synapses in the interpeduncular nucleus.

Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment.

Geometry and the Organizational Principle of Spine Synapses along a Dendrite.

Alternative mitochondrial quality control mediated by extracellular release.

Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose).

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons.

CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue.

Three-Dimensional Structure of Dendritic Spines Revealed by Volume Electron Microscopy Techniques.

Melanocyte progenitor cells reside in human subcutaneous adipose tissue.

Susceptibility of subregions of prefrontal cortex and corpus callosum to damage by high-dose oxytocin-induced labor in male neonatal mice.

Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity.

Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, ScaeSF.

An optimized protocol for immuno-electron microscopy of endogenous LC3.