standardized-rat-coronary-ring-preparation-real-time-recording

Standardized Rat Coronary Ring Preparation and Real-Time Recording of Dynamic Tension Changes Along Vessel Diameter

As a key event of cardiovascular system diseases, coronary artery disease (CAD) has been widely regarded as the main culprit of atherosclerosis, ...

real-time-detection-dynamic-affinity-between-biomolecules-using

Real-Time Detection of Dynamic Affinity between Biomolecules Using Surface Plasmon Resonance (SPR) Technology

Surface plasmon resonance (SPR) technology is a sensitive precise method for detecting viruses, pathogenic molecular proteins, and receptors, determining ...

real-time-detection-ferulic-acid-effects-on-rat-left-ventricle-using

Real-Time Detection of Ferulic Acid Effects on Rat Left Ventricle Using Pressure-Volume Conductivity Catheter

Decreased cardiac function can have a negative impact on other organs. The left ventricular pressure-volume relationship is considered to be a valid ...

using-an-vitro-tissue-perfusion-system-to-detect-functional

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Gastrointestinal diseases, which have a high incidence, pose considerable challenges for humans. The small intestine is integral to food and drug ...

recording-inward-rectifying-k-currents-freshly-isolated-basilar

Recording of Inward Rectifying K<sup>+</sup> Currents in Freshly Isolated Basilar Artery Smooth Muscle Cells by Patch Clamp Technique

Cerebrovascular disease is a prevalent condition among the elderly, with its incidence steadily rising. The basilar artery is a critical cerebral vessel ...

Chengdu University of Traditional Chinese Medicine

G protein-coupled receptors (GPCRs) widely exist in vivo and participate in many physiological processes, thus emerging as important targets for drug development. Approximately 30% of the Food and Drug Administration (FDA)-approved drugs target GPCRs. To date, the 'one disease, one target, one molecule' strategy no longer meets the demands of drug development. Meanwhile, small-molecule drugs account for 60% of FDA-approved drugs. Traditional Chinese medicine (TCM) has garnered widespread attention for its unique theoretical system and treatment methods. TCM involves multiple components, targets and pathways. Centered on GPCRs and TCM, this paper discusses the similarities and differences between TCM and GPCRs from the perspectives of syndrome of TCM, the consistency of TCM's multi-component and multi-target approaches and the potential of GPCRs and TCM in the development of novel drugs. A novel strategy, 'simultaneous screening of drugs and targets', was proposed and applied to the study of GPCRs. We combine GPCRs with TCM to facilitate the modernisation of TCM, provide valuable insights into the rational application of TCM and facilitate the research and development of novel drugs. This study offers theoretical support for the modernisation of TCM and introduces novel ideas for development of safe and effective drugs.

G protein-coupled receptors and traditional Chinese medicine: new thinks for the development of traditional Chinese medicine.

Danggui Buxue Decoction (DBD), a classic representative prescription of invigorating Qi and producing blood, is used to treat coronary heart disease angina pectoris and vascular injury diseases. Abnormal coronary artery is an important cause of cardiovascular disease. However, the mechanism of DBD dilates coronary arteries is still unclear.

Article Total : 5	Year
Publication title	2022
Publication title	2023
Publication title	2024
Publication title	2024
Publication title	2025

Article	Year
G protein-coupled receptors and traditional Chinese medicine: new thinks for the development of traditional Chinese medicine. Chinese medicine\| PubMed ID: 38956679	2024
Danggui Buxue Decoction and its components dilate coronary artery through activating the inward rectification K channels pathway. Journal of ethnopharmacology\| PubMed ID: 39521101	2024

Wenqiao An

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