Department of Medicine,
Division of Allergy,
Pulmonary,
and Critical Care Medicine
Timothy S. Blackwell has not added Biography.
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Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation.
American journal of respiratory cell and molecular biology Aug, 2006 | Pubmed ID: 16543608
Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin.
American journal of respiratory cell and molecular biology May, 2002 | Pubmed ID: 11970909
Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kappaB activation in a transgenic mouse model.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Mar-Apr, 2002 | Pubmed ID: 11992813
Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice.
American journal of physiology. Lung cellular and molecular physiology Jun, 2002 | Pubmed ID: 12003780
Modulation of endotoxin-induced NF-kappa B activation in lung and liver through TNF type 1 and IL-1 receptors.
American journal of physiology. Lung cellular and molecular physiology Dec, 2002 | Pubmed ID: 12388356
Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2003 | Pubmed ID: 12517978
Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2003 | Pubmed ID: 12626586
Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis.
The Journal of surgical research Mar, 2003 | Pubmed ID: 12697416
Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Jun, 2003 | Pubmed ID: 12754285
Endotoxin potentiates lung injury in cerulein-induced pancreatitis.
American journal of surgery Nov, 2003 | Pubmed ID: 14599619
Mice are resistant to the induction of a pleurodesis.
Chest Dec, 2003 | Pubmed ID: 14665535
Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3.
American journal of physiology. Lung cellular and molecular physiology May, 2004 | Pubmed ID: 14672923
p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2004 | Pubmed ID: 14734763
Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1.
The Journal of biological chemistry Feb, 2004 | Pubmed ID: 14966110
Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10.
American journal of respiratory cell and molecular biology Oct, 2004 | Pubmed ID: 15205180
Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2004 | Pubmed ID: 15240724
CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels.
American journal of physiology. Lung cellular and molecular physiology Feb, 2005 | Pubmed ID: 15516494
Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation.
Journal of leukocyte biology Feb, 2005 | Pubmed ID: 15563581
Characterization of fibroblast-specific protein 1 in pulmonary fibrosis.
American journal of respiratory and critical care medicine Apr, 2005 | Pubmed ID: 15618458
Pathogen-host interactions in Pseudomonas aeruginosa pneumonia.
American journal of respiratory and critical care medicine Jun, 2005 | Pubmed ID: 15695491
Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.
Journal of virology Jun, 2005 | Pubmed ID: 15919917
Variability of interalveolar septal remodeling after bleomycin treatment in mice.
Ultrastructural pathology Jan-Feb, 2005 | Pubmed ID: 15934165
Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions.
Chest Jun, 2005 | Pubmed ID: 15947325
The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice.
Blood Nov, 2005 | Pubmed ID: 15985536
Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia.
American journal of physiology. Lung cellular and molecular physiology Sep, 2005 | Pubmed ID: 16093364
Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages.
The Journal of biological chemistry Oct, 2005 | Pubmed ID: 16100121
Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease.
The Journal of clinical investigation Sep, 2005 | Pubmed ID: 16100570
Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion.
American journal of respiratory cell and molecular biology Feb, 2006 | Pubmed ID: 16210694
Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.
The American journal of pathology Nov, 2005 | Pubmed ID: 16251411
Bioluminescence imaging.
Proceedings of the American Thoracic Society , 2005 | Pubmed ID: 16352761
Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases.
The Journal of biological chemistry Feb, 2006 | Pubmed ID: 16371369
Hyperoxia and apoptosis in developing mouse lung mesenchyme.
Pediatric research Feb, 2006 | Pubmed ID: 16439576
Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2006 | Pubmed ID: 16585588
Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2006 | Pubmed ID: 16585596
NIK is involved in nucleosomal regulation by enhancing histone H3 phosphorylation by IKKalpha.
The Journal of biological chemistry Jul, 2006 | Pubmed ID: 16675465
Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase.
American journal of physiology. Heart and circulatory physiology Oct, 2006 | Pubmed ID: 16679392
Vascular endothelial growth factor levels in post-CABG pleural effusions are associated with pleural inflammation and permeability.
Respiratory medicine Feb, 2007 | Pubmed ID: 16854577
Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis.
Pancreas Oct, 2006 | Pubmed ID: 17003648
Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells.
Journal of leukocyte biology Mar, 2007 | Pubmed ID: 17135575
Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2007 | Pubmed ID: 17202330
Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages.
American journal of physiology. Lung cellular and molecular physiology May, 2007 | Pubmed ID: 17220375
A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis.
The Journal of biological chemistry Mar, 2007 | Pubmed ID: 17261585
Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2.
European journal of immunology Apr, 2007 | Pubmed ID: 17330822
Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway.
Journal of immunology (Baltimore, Md. : 1950) May, 2007 | Pubmed ID: 17475880
Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice.
American journal of physiology. Lung cellular and molecular physiology Aug, 2007 | Pubmed ID: 17545492
Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia.
Virchows Archiv : an international journal of pathology Oct, 2007 | Pubmed ID: 17674038
Induction and function of lipocalin prostaglandin D synthase in host immunity.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2007 | Pubmed ID: 17675519
Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice.
The American journal of pathology Oct, 2007 | Pubmed ID: 17717145
Tumor necrosis factor-alpha promotes malignant pleural effusion.
Cancer research Oct, 2007 | Pubmed ID: 17942913
Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2007 | Pubmed ID: 18000061
Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis.
Clinical & experimental metastasis , 2008 | Pubmed ID: 18008176
Disease-specific gene expression profiling in multiple models of lung disease.
American journal of respiratory and critical care medicine Feb, 2008 | Pubmed ID: 18029791
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.
Nature medicine Jan, 2008 | Pubmed ID: 18066075
Host nuclear factor-kappaB activation potentiates lung cancer metastasis.
Molecular cancer research : MCR Mar, 2008 | Pubmed ID: 18337446
Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation.
Transplantation Mar, 2008 | Pubmed ID: 18360274
Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection.
American journal of physiology. Lung cellular and molecular physiology Jun, 2008 | Pubmed ID: 18390830
Genetic determination of the role of PU.1 in macrophage gene expression.
Biochemical and biophysical research communications Jul, 2008 | Pubmed ID: 18485892
Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid.
The Journal of biological chemistry Jul, 2008 | Pubmed ID: 18490445
The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth.
Cancer research Aug, 2008 | Pubmed ID: 18701501
A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion.
Journal of the National Cancer Institute Oct, 2008 | Pubmed ID: 18840818
Bioluminescence: imaging modality for in vitro and in vivo gene expression.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 19082962
Myeloid cells control termination of lung inflammation through the NF-kappaB pathway.
American journal of physiology. Lung cellular and molecular physiology Mar, 2009 | Pubmed ID: 19098124
Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.
American journal of physiology. Lung cellular and molecular physiology May, 2009 | Pubmed ID: 19181746
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart.
The Journal of clinical investigation Apr, 2009 | Pubmed ID: 19273909
Development of animal models for the acute respiratory distress syndrome.
Disease models & mechanisms May-Jun, 2009 | Pubmed ID: 19407329
Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG.
PloS one , 2009 | Pubmed ID: 19436730
Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis.
American journal of respiratory and critical care medicine Oct, 2009 | Pubmed ID: 19556518
CpG oligodeoxynucleotide triggers the liver inflammatory reaction and abrogates spontaneous tolerance.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Aug, 2009 | Pubmed ID: 19642135
The protein kinase IKKepsilon regulates energy balance in obese mice.
Cell Sep, 2009 | Pubmed ID: 19737522
Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection.
Journal of cellular physiology Jan, 2010 | Pubmed ID: 19746431
Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice.
Experimental lung research Dec, 2009 | Pubmed ID: 19995280
TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation.
American journal of respiratory and critical care medicine Apr, 2010 | Pubmed ID: 20007931
Discovery of an operon that participates in agmatine metabolism and regulates biofilm formation in Pseudomonas aeruginosa.
Molecular microbiology Apr, 2010 | Pubmed ID: 20149107
Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study.
Molecular cancer , 2010 | Pubmed ID: 20219102
Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model.
PloS one , 2010 | Pubmed ID: 20221440
NADPH oxidase limits innate immune responses in the lungs in mice.
PloS one , 2010 | Pubmed ID: 20300512
Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC.
Chest Apr, 2010 | Pubmed ID: 20371530
Role of NADPH oxidase in host defense against aspergillosis.
Medical mycology : official publication of the International Society for Human and Animal Mycology Apr, 2011 | Pubmed ID: 20560866
Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology Oct, 2010 | Pubmed ID: 20562227
Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.
American journal of respiratory and critical care medicine Nov, 2010 | Pubmed ID: 20595227
Pseudomonas aeruginosa: host defence in lung diseases.
Respirology (Carlton, Vic.) Oct, 2010 | Pubmed ID: 20723140
Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice.
Respiratory research , 2010 | Pubmed ID: 20796309
NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20861353
Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.
The Journal of biological chemistry Dec, 2010 | Pubmed ID: 20937835
Let It Be: microRNAs impact interstitial lung disease.
American journal of respiratory and critical care medicine Jan, 2011 | Pubmed ID: 21193781
TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment.
American journal of physiology. Lung cellular and molecular physiology Jun, 2011 | Pubmed ID: 21441353
Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine Aug, 2011 | Pubmed ID: 21512171
Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium.
The Journal of pathology Jun, 2011 | Pubmed ID: 21557221
Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo.
Free radical biology & medicine Jul, 2011 | Pubmed ID: 21605660
Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction.
The American journal of the medical sciences Jun, 2011 | Pubmed ID: 21613930
Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2011 | Pubmed ID: 21670280
Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21757695
PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.
American journal of physiology. Lung cellular and molecular physiology Oct, 2011 | Pubmed ID: 21764988
NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2011 | Pubmed ID: 21775686
Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts.
PloS one , 2011 | Pubmed ID: 21814580
NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.
Breast cancer research : BCR , 2011 | Pubmed ID: 21884585
NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.
PloS one , 2011 | Pubmed ID: 21887257
Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.
Antimicrobial agents and chemotherapy Dec, 2011 | Pubmed ID: 21947386
Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury.
American journal of physiology. Lung cellular and molecular physiology Jan, 2012 | Pubmed ID: 22003088
A critical role for macrophages in promotion of urethane-induced lung carcinogenesis.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2011 | Pubmed ID: 22048774
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense.
PloS one , 2011 | Pubmed ID: 22163282
Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology Mar, 2012 | Pubmed ID: 22180659
Structure and function of OprD protein in Pseudomonas aeruginosa: from antibiotic resistance to novel therapies.
International journal of medical microbiology : IJMM Mar, 2012 | Pubmed ID: 22226846
Role of Endoplasmic Reticulum Stress in Age-Related Susceptibility to Lung Fibrosis.
American journal of respiratory cell and molecular biology Jan, 2012 | Pubmed ID: 22227563
Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis.
Carcinogenesis Apr, 2012 | Pubmed ID: 22287559
Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology Apr, 2012 | Pubmed ID: 22287606
Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
Cell Feb, 2012 | Pubmed ID: 22304915
Telomerase deficiency does not alter bleomycin-induced fibrosis in mice.
Experimental lung research Apr, 2012 | Pubmed ID: 22394286
Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice.
Experimental lung research Apr, 2012 | Pubmed ID: 22394287
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2012 | Pubmed ID: 22415303
Regulation of innate immunity by NADPH oxidase.
Free radical biology & medicine Jul, 2012 | Pubmed ID: 22583699
MicroRNA-181b regulates NF-κB-mediated vascular inflammation.
The Journal of clinical investigation Jun, 2012 | Pubmed ID: 22622040
Cooperation Between Classical and Alternative NF-κB Pathways Regulates Pro-Inflammatory Responses in Epithelial Cells.
American journal of respiratory cell and molecular biology Jun, 2012 | Pubmed ID: 22652196
The Alveolar Epithelium Determines Susceptibility to Lung Fibrosis in Hermansky-Pudlak Syndrome.
American journal of respiratory and critical care medicine Oct, 2012 | Pubmed ID: 23043085
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