Marc K. Hellerstein

Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: studies in vitro, in animals, and in humans.

Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy.

Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk.

Measurement of mitochondrial DNA synthesis in vivo using a stable isotope-mass spectrometric technique.

In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research.

Turnover of adipose components and mitochondrial DNA in humans: kinetic biomarkers for human immunodeficiency virus-associated lipodystrophy and mitochondrial toxicity?

New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping.

Stable isotope-mass spectrometric measurements of molecular fluxes in vivo: emerging applications in drug development.

Effect of nucleoside reverse transcriptase inhibitors on mitochondrial DNA synthesis in rats and humans.

In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis.

Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans.

Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice.

Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats.

Alternate-day fasting and chronic disease prevention: a review of human and animal trials.

A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: advantages of pathway-based discovery.

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility.

Do calorie restriction or alternate-day fasting regimens modulate adipose tissue physiology in a way that reduces chronic disease risk?

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in mice.

Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.

Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: validation of a simplified method suitable for multi-center clinical studies.

Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates.

The effects of physiological adaptations to calorie restriction on global cell proliferation rates.

Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration.

The effect of long term calorie restriction on in vivo hepatic proteostatis: a novel combination of dynamic and quantitative proteomics.

A pilot study demonstrating a non-invasive method for the measurement of protein turnover in skin disorders: application to psoriasis.

Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D-creatine dilution method.

Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease.

Treatment of diabetic rats with insulin or a synthetic insulin receptor agonist peptide leads to divergent metabolic responses.

In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans.

Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.

Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.

Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood.

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.

Association of In Vivo Adipose Tissue Cellular Kinetics With Markers of Metabolic Health in Humans.

Racial differences in in vivo adipose lipid kinetics in humans.

Measurement of Leukemic B-Cell Growth Kinetics in Patients with Chronic Lymphocytic Leukemia.

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease.

Surprising findings in a 'well-understood' nutrient-assimilation pathway.

De novo lipogenesis is essential for platelet production in humans.

Adipose depot-specific effects of 16 weeks of pioglitazone on in vivo adipogenesis in women with obesity: a randomised controlled trial.

Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo.

Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients.

Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate.

24-hydroxycholesterol replacement rate measured in blood is a non-invasive biomarker of brain demyelination and remyelination in cuprizone-treated mice.