Lacy M. Alexander

Department of Kinesiology, The Pennsylvania State University

Affiliated withThe Pennsylvania State University

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
Local ascorbate administration augments NO- and non-NO-dependent reflex cutaneous vasodilation in hypertensive humans. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17483240	2007
Altered mechanisms of vasodilation in aged human skin. Exercise and sport sciences reviews\| PubMed ID: 17620930	2007
The human cutaneous circulation as a model of generalized microvascular function. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17932300	2008
Human cutaneous microvascular ageing: potential insights into underlying physiological mechanisms of endothelial function and dysfunction. The Journal of physiology\| PubMed ID: 18625801	2008
Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19036898	2009
Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19661446	2009
Aging and the control of human skin blood flow. Frontiers in bioscience (Landmark edition)\| PubMed ID: 20036842	2010
Systemic low-dose aspirin and clopidogrel independently attenuate reflex cutaneous vasodilation in middle-aged humans. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 20360429	2010
Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 20413421	2010
Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans. The Journal of physiology\| PubMed ID: 21486801	2011
Oral atorvastatin therapy increases nitric oxide-dependent cutaneous vasodilation in humans by decreasing ascorbate-sensitive oxidants. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 21715698	2011
Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans. The Journal of physiology\| PubMed ID: 21807618	2011
Sex differences in the control of acral skin blood flow in humans: differential regulation of cyclooxygenase in α-adrenergic signalling. The Journal of physiology\| PubMed ID: 22042544	2011
Sodium loading and cutaneous microvascular function: more than skin deep. The Journal of physiology\| PubMed ID: 23118066	2012
Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress. Medicine and science in sports and exercise\| PubMed ID: 23135368	2013
Cutaneous microvascular dysfunction correlates with serum LDL and sLOX-1 receptor concentrations. Microvascular research\| PubMed ID: 23137925	2013
Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanisms. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 23193114	2013
Regional relation between skin blood flow and sweating to passive heating and local administration of acetylcholine in young, healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 23389110	2013
Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans. Microvascular research\| PubMed ID: 23481864	2013
Blood pressure regulation III: what happens when one system must serve two masters: temperature and pressure regulation? European journal of applied physiology\| PubMed ID: 23636697	2014
Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 23743404	2013
Oral clopidogrel improves cutaneous microvascular function through EDHF-dependent mechanisms in middle-aged humans. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 23804278	2013
Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 23869061	2013
Nonuniform, age-related decrements in regional sweating and skin blood flow. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 23926135	2013
Altered skin flowmotion in hypertensive humans. Microvascular research\| PubMed ID: 24418051	2015
Heat waves, aging, and human cardiovascular health. Medicine and science in sports and exercise\| PubMed ID: 24598696	2014
Laser-speckle contrast imaging: a novel method for assessment of cutaneous blood flow in perniosis. JAMA dermatology\| PubMed ID: 24623395	2014
Nitric oxide-mediated cutaneous microvascular function is not altered in middle-aged-to-older adults following mild SARS-CoV-2 infection: A pilot study. Physiological reports\| PubMed ID: 37269174	2023
Sex- and limb-specific differences in the nitric oxide-dependent cutaneous vasodilation in response to local heating. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 25100074	2014
Muscle sympathetic nerve activity during cold stress and isometric exercise in healthy older adults. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 25103970	2014
Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans. The Journal of physiology\| PubMed ID: 25260636	2014
Lack of limb or sex differences in the cutaneous vascular responses to exogenous norepinephrine. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 25342706	2014
Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature. The Journal of physiology\| PubMed ID: 25639684	2015
Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction. The Journal of physiology\| PubMed ID: 25752518	2015
Sympathetic control of reflex cutaneous vasoconstriction in human aging. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 26272321	2015
Impairments in central cardiovascular function contribute to attenuated reflex vasodilation in aged skin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 26494450	2015
Sympathetic regulation during thermal stress in human aging and disease. Autonomic neuroscience : basic & clinical\| PubMed ID: 26627337	2016
Endothelin-1 modulates methacholine-induced cutaneous vasodilatation but not sweating in young human skin. The Journal of physiology\| PubMed ID: 26846374	2016
Topical menthol increases cutaneous blood flow. Microvascular research\| PubMed ID: 27131832	2016
Acute dairy milk ingestion does not improve nitric oxide-dependent vasodilation in the cutaneous microcirculation. The British journal of nutrition\| PubMed ID: 27180680	2016
Blunted increases in skin sympathetic nerve activity are related to attenuated reflex vasodilation in aged human skin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 27789772	2016
Neurovascular mechanisms underlying augmented cold-induced reflex cutaneous vasoconstriction in human hypertension. The Journal of physiology\| PubMed ID: 27891612	2017
Mechanisms and time course of menthol-induced cutaneous vasodilation. Microvascular research\| PubMed ID: 27899298	2017
Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps. Muscle & nerve\| PubMed ID: 28192854	2017
Folic acid supplementation increases cutaneous vasodilator sensitivity to sympathetic nerve activity in older adults. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 28228418	2017
Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 28348008	2017
Blood pressure normalization via pharmacotherapy improves cutaneous microvascular function through NO-dependent and NO-independent mechanisms. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 28510986	2017
Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 28860170	2017
Sympathetic function during whole body cooling is altered in hypertensive adults. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 28912362	2017
Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia. Clinical science (London, England : 1979)\| PubMed ID: 29042489	2017
Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 29054972	2018
Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 29167120	2018
Vascular aging. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 29878874	2018
Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder. Circulation research\| PubMed ID: 30582458	2019
Self-Reported Everyday Psychosocial Stressors Are Associated With Greater Impairments in Endothelial Function in Young Adults With Major Depressive Disorder. Journal of the American Heart Association\| PubMed ID: 30741602	2019
Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study. Scientific reports\| PubMed ID: 30886182	2019
Publisher Correction: Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study. Scientific reports\| PubMed ID: 31337775	2019
Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxi... The Journal of nutrition\| PubMed ID: 31504721	2020
Dairy Foods and Dairy Fats: New Perspectives on Pathways Implicated in Cardiometabolic Health. Advances in nutrition (Bethesda, Md.)\| PubMed ID: 31555799	2020
Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 31577152	2020
Peripheral microvascular serotoninergic signaling is dysregulated in young adults with major depressive disorder. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 31751182	2020
Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow. European journal of applied physiology\| PubMed ID: 31776694	2020
Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults. Journal of the American Heart Association\| PubMed ID: 32340506	2020
Childhood socioeconomic status, comorbidity of chronic kidney disease risk factors, and kidney function among adults in the midlife in the United States (MIDUS) study. BMC nephrology\| PubMed ID: 32429854	2020
AHA/ACC-defined stage 1 hypertensive adults do not display cutaneous microvascular endothelial dysfunction. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 32734817	2020
Four weeks of vitamin D supplementation improves nitric oxide-mediated microvascular function in college-aged African Americans. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 32857616	2020
Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 32940559	2020
Temperature regulation during exercise in the heat: Insights for the aging athlete. Journal of science and medicine in sport\| PubMed ID: 33358656	2021
Hydrogen sulfide-dependent microvascular vasodilation is improved following chronic sulfhydryl-donating antihypertensive pharmacotherapy in adults with hypertension. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 34477463	2021
Kinesiology tape modestly increases skin blood flow regardless of tape application technique. Journal of performance health research\| PubMed ID: 34527888	2017
Vascular Health Triad in Humans With Hypertension-Not the Usual Suspects. Frontiers in physiology\| PubMed ID: 34658930	2021
Menthol-induced activation of TRPM8 receptors increases cutaneous blood flow across the dermatome. Microvascular research\| PubMed ID: 34717968	2022
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 34995164	2022
Why gender equity should remain a focus for the American Physiological Society. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 35179979	2022
Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 35363580	2022
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 35930446	2022
Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvascular research\| PubMed ID: 35970408	2022
Back to the future. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 37055037	2023