Marcelo Cypel

Anti-human tissue factor antibody ameliorated intestinal ischemia reperfusion-induced acute lung injury in human tissue factor knock-in mice.

Technique for prolonged normothermic ex vivo lung perfusion.

Activated protein C in ischemia-reperfusion injury after experimental lung transplantation.

PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentation.

Functional repair of human donor lungs by IL-10 gene therapy.

Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysis.

Increased levels of interleukin-1β and tumor necrosis factor-α in donor lungs rejected for transplantation.

Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways.

Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.

Expansion of the donor lung pool: use of lungs from smokers.

Experience with the first 50 ex vivo lung perfusions in clinical transplantation.

Physiologic assessment of the ex vivo donor lung for transplantation.

Bone marrow-derived progenitor cells in end-stage lung disease patients.

Advances in lung preservation.

Modified in vivo lung perfusion allows for prolonged perfusion without acute lung injury.

Long-term outcome after en bloc resection of non-small-cell lung cancer invading the pulmonary sulcus and spine.

Extracorporeal life support for adults with severe acute respiratory failure.

Low invasive in vivo tissue sampling for monitoring biomarkers and drugs during surgery.

Long-term outcome after resection of non-small cell lung cancer invading the thoracic inlet.

Ex vivo lung perfusion.

Protein expression profiling predicts graft performance in clinical ex vivo lung perfusion.

Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation.

Neoadjuvant chemoradiation and surgery improves survival outcomes compared with definitive chemoradiation in the treatment of stage IIIA N2 non-small-cell lung cancer.

Outcomes of intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation.

The role of the endothelin-1 pathway as a biomarker for donor lung assessment in clinical ex vivo lung perfusion.

Retrospective Analysis of Lung Transplant Recipients Found to Have Unexpected Lung Cancer in Explanted Lungs.

Cardiopulmonary Bypass and Extracorporeal Life Support for Emergent Intraoperative Thoracic Situations.

Low-dose computed tomography volumetry for subtyping chronic lung allograft dysfunction.

Successful lung transplantation from a donation after cardiocirculatory death donor taking more than 120 minutes to cardiac arrest after withdrawal of life support therapies.

Using the inherent chemistry of the endothelin-1 peptide to develop a rapid assay for pre-transplant donor lung assessment.

Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation.

Annexin V homodimer protects against ischemia reperfusion-induced acute lung injury in lung transplantation.

Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.

Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin.

The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation.

Human α1-antitrypsin improves early post-transplant lung function: Pre-clinical studies in a pig lung transplant model.

One-Year Outcomes in Caregivers of Critically Ill Patients.

Mesenchymal stem cell treatment is associated with decreased perfusate concentration of interleukin-8 during ex vivo perfusion of donor lungs after 18-hour preservation.

Evaluation of a New Ultrasound Thoracoscope for Localization of Lung Nodules in Ex Vivo Human Lungs.

Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study.

Intensive Care Physiotherapy during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome.

Bilateral pneumonectomy to treat uncontrolled sepsis in a patient awaiting lung transplantation.

Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury.

Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model.

Sevoflurane Attenuates Ischemia-Reperfusion Injury in a Rat Lung Transplantation Model.

High Risk for Thoracotomy but not Thoracoscopic Lobectomy.

Cost-effectiveness of mediastinal lymph node staging in non-small cell lung cancer.

A novel minimally invasive near-infrared thoracoscopic localization technique of small pulmonary nodules: A phase I feasibility trial.

Higher M30 and high mobility group box 1 protein levels in ex vivo lung perfusate are associated with primary graft dysfunction after human lung transplantation.

Extracorporeal support in airway surgery.

Performance of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Isolated Mediastinal and Hilar Lymphadenopathy.

α-Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion.

Metabolic Profile of Ex Vivo Lung Perfusate Yields Biomarkers for Lung Transplant Outcomes.

Extracorporeal life support as a bridge to lung transplantation-experience of a high-volume transplant center.

Lung in a Box: Ex Vivo Lung Transplantation.

Effects of Warm Versus Cold Ischemic Donor Lung Preservation on the Underlying Mechanisms of Injuries During Ischemia and Reperfusion.

Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.

Equilibrium ex vivo calibration of homogenized tissue for in vivo SPME quantitation of doxorubicin in lung tissue.

Efficacy and Cost of Awake Thoracoscopy and Video-Assisted Thoracoscopic Surgery in the Undiagnosed Pleural Effusion.

Comprehensive outcomes after lung retransplantation: A single-center review.

Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation.

Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1-mediated ischemia-reperfusion injury after lung transplantation.

Introducing the concept of semielective lung transplantation through the use of ex vivo lung perfusion.

Pig lung transplant survival model.

Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation.

Commentary: To die or not to die-rescuing lung cells from ischemia-reperfusion injury.

Spectrum of chronic lung allograft pathology in a mouse minor-mismatched orthotopic lung transplant model.

Neutrophil extracellular traps in lung perfusion perfusate predict the clinical outcome of lung transplant recipients.

Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion.

CT-guided Microcoil Pulmonary Nodule Localization prior to Video-assisted Thoracoscopic Surgery: Diagnostic Utility and Recurrence-Free Survival.

Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2.

Donor prone positioning protects lungs from injury during warm ischemia.

Veno-venous extracorporeal life support for blastomycosis-associated acute respiratory distress syndrome.

Ex-vivo lung perfusion and ventilation: where to from here?

A successful lung transplant from a 3-year-old donor after controlled cardiac death followed by ex vivo lung perfusion: A case report.

Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation.

Drug-resistant cytomegalovirus infection after lung transplantation: Incidence, characteristics, and clinical outcomes.

Bilateral Lobar Transplants Using One Donor for Two Small-Sized Recipients.

Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion.

Normothermic ex vivo lung perfusion: Does the indication impact organ utilization and patient outcomes after transplantation?

Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial.

Incidence of Ipsilateral Side Recurrence After Open or Video-Assisted Thoracic Surgery Resection of Colorectal Lung Metastases.

Commentary: Use of hepatitis C virus viremic donors should be the standard of care.

Initial lung transplantation experience with uncontrolled donation after cardiac death in North America.

Increased Arginase Expression and Decreased Nitric Oxide in Pig Donor Lungs after Normothermic Ex Vivo Lung Perfusion.

Airway Oscillometry Detects Spirometric-Silent Episodes of Acute Cellular Rejection.

Should All Donors Be Treated by Ex Vivo Lung Perfusion?-Reply.

An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function.

A model to assess acute and delayed lung toxicity of oxaliplatin during in vivo lung perfusion.

Short-course, direct-acting antivirals and ezetimibe to prevent HCV infection in recipients of organs from HCV-infected donors: a phase 3, single-centre, open-label study.

Immunosuppressive Therapy in Lung Transplantation.

Video-Assisted Thoracic Surgery as the Future of Pulmonary Metastasectomy: Reply.

Deceased-donor lobar lung transplant: A successful strategy for small-sized recipients.

Impact of donor time to cardiac arrest in lung donation after circulatory death.

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation.

Lung donation after medical assistance in dying at home.

When to consider lung transplantation for COVID-19.

Ex vivo perfusion in lung transplantation and removal of HCV: the next level.

Cell-free DNA in human ex vivo lung perfusate as a potential biomarker to predict the risk of primary graft dysfunction in lung transplantation.

The impact of concordance with a lung cancer diagnosis pathway guideline on treatment access in patients with stage IV lung cancer.

Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation.

Strategies to prolong homeostasis of ex vivo perfused lungs.

Ex vivo lung perfusion for donor lung assessment and repair: a review of translational interspecies models.

Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study.

Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS.

Transcriptomic investigation reveals donor-specific gene signatures in human lung transplants.

Ventilation parameters and early graft function in double lung transplantation.

Donor ventilation parameters as predictors for length of mechanical ventilation after lung transplantation: Results of a prospective multicenter study.

Safety of continuous 12-hour delivery of antimicrobial doses of inhaled nitric oxide during ex vivo lung perfusion.

Commentary: Bruised donor lungs-they may not be pretty, but they will still work.

Successful lung transplantation from lungs procured 12 hours after withdrawal of life-sustaining therapy: Changing the paradigm of controlled DCD donors?

Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion.

A call to routinely test lower respiratory tract samples for SARS-CoV-2 in lung donors.

Prediction of donor related lung injury in clinical lung transplantation using a validated ex vivo lung perfusion inflammation score.

Use of metabolomics to identify strategies to improve and prolong ex vivo lung perfusion for lung transplants.

Predicting donor lung acceptance for transplant during ex vivo lung perfusion: The EX vivo lung PerfusIon pREdiction (EXPIRE).

Pushing the Envelope for Donor Lungs.

Determination of Optical Properties and Photodynamic Threshold of Lung Tissue for Treatment Planning of In Vivo Lung Perfusion Assisted Photodynamic Therapy.

An Ingenious Approach for Lobar Lung Transplantation.

Long-term outcomes of sensitized lung transplant recipients after peri-operative desensitization.

Achieving Safe Liberation During Weaning From VV-ECMO in Patients With Severe ARDS: The Role of Tidal Volume and Inspiratory Effort.

Surfactant therapy in lung transplantation: A systematic review and meta-analysis.

Lung transplant recipient attitudes and beliefs on accepting an organ that is positive for hepatitis C virus.

delivery of regulatory T-cells for control of alloimmune priming in the donor lung.

Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function.

Lung transplantation for acute COVID-19: the Toronto Lung Transplant Program experience.

A novel pre-clinical strategy to deliver antimicrobial doses of inhaled nitric oxide.

Engineered mesenchymal stromal cell therapy during human lung lung perfusion is compromised by acidic lung microenvironment.

Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin.

[Not Available].

Postoperative Management of Lung Transplant Recipients in the Intensive Care Unit.

lung perfusion.

Outcomes of lung transplantation from organ donation after medical assistance in dying: First North American experience.

Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs.

Donation after circulatory death donors in high-risk recipients undergoing bilateral lung transplantation: An ISHLT database registry analysis.

Importance of tumor size in resectable stage III-N2 non-small cell lung cancer.

Performance Measures for Lung Transplantation: Change Is Coming.

Lung transplantation for acute respiratory distress syndrome.

Near-infrared fluorescence imaging during ex vivo lung perfusion: Noninvasive real-time evaluation of regional lung perfusion and edema.

The gift of organ donation as a last wish.

Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation.

Endobronchial ultrasound-guided bipolar radiofrequency ablation for lung cancer: A first-in-human clinical trial.

Outcomes of lung transplantation at a Canadian center using donors declined in the United States.

Donation after circulatory death and lung transplantation.

Centralized Organ Recovery and Reconditioning Centers.

Seminars AATS International Roundtable of Lung Transplantation for COVID-19.

Successful sequential transplantation of 2 single lungs from the same donor into 2 different recipients-use of standard cold preservation and 10 °C preservation.

Extra-Pleural Pneumonectomy (EPP) in Children and Adults with Locally Advanced Sarcoma: A CanSaRCC Study.

High Doses of Inhaled Nitric Oxide as an Innovative Antimicrobial Strategy for Lung Infections.

Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy.

Successful use of a hepatitis C viremic donor in pediatric bilateral lobar lung transplantation.

Transesophageal Echocardiography-Guided Extracorporeal Membrane Oxygenation Cannulation in COVID-19 Patients.

Extracorporeal life support as a bridge to lung transplantation: Where are we now?

The metabolic fate of oxaliplatin in the biological milieu investigated during lung perfusion using a unique miniaturized sampling approach based on solid-phase microextraction coupled with liquid chromatography-mass spectrometry.

A biomarker assay to risk-stratify patients with symptoms of respiratory tract infection.

Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolonged lung perfusion using SPME coupled with LC-HRMS.

The Association Between Extravascular Lung Water and Critical Care Outcomes Following Bilateral Lung Transplantation.

Outcomes of lung transplantation from donors with a history of substance abuse.

Evaluation of 10°C as the optimal storage temperature for aspiration-injured donor lungs in a large animal transplant model.

Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: A retrospective cohort study.

L-alanyl-L-glutamine modified perfusate improves human lung cell functions and extend porcine ex vivo lung perfusion.

Overcoming the Limits of Lung Transplantation: 10°C Static Cold Preservation.

Influence of anterior tumor location on survival after resection of lung cancer invading the thoracic inlet (Pancoast tumors).

Prevention and Management of Chronic Postsurgical Pain and Persistent Opioid Use Following Solid Organ Transplantation: Experiences From the Toronto General Hospital Transitional Pain Service.

Testing the delivery of human organ transportation with drones in the real world.

Low-Flow Inflation Pressure-Time Curve to Identify Airway Opening Pressure in a Patient Receiving Venovenous Extracorporeal Membrane Oxygenation.

Triaging donor lungs based on a microaspiration signature that predicts adverse recipient outcome.

Expanding the Lung Donor Pool: Donation After Circulatory Death, Ex-Vivo Lung Perfusion and Hepatitis C Donors.

Alpha-1-antitrypsin safely promotes rapid recovery of pigs after lung transplantation.

Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization.

Outcomes of patients with respiratory failure declined for extracorporeal membrane oxygenation: a prospective observational study.

Intra-subject variability in oscillometry correlates with acute rejection and CLAD post-lung transplant.

Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression.

Time to extubation for lung transplant recipients represents a pragmatic end-point to guide the development of prognostic tests.

Incidence of post-transplant cytomegalovirus viremia in patients receiving lungs after ex vivo lung perfusion.

Identification of regional variation in gene expression and inflammatory proteins in donor lung tissue and ex vivo lung perfusate.

Extending the age criteria of lung transplant donors to 70+ years old does not significantly affect recipient survival.

A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization.