William Kwok

Kwok Laboratory, Benaroya Research Institute

Affiliated withBenaroya Research Institute Benaroya Research Institute

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2009

Other Publications

Article	Year
Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis. Arthritis and rheumatism\| PubMed ID: 11817597	2002
HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells. Arthritis and rheumatism\| PubMed ID: 11817608	2002
Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones. Human immunology\| PubMed ID: 11872236	2002
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. Diabetes\| PubMed ID: 11978633	2002
Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding. Journal of neuroimmunology\| PubMed ID: 12020970	2002
HLA class II peptide-binding and autoimmunity. Tissue antigens\| PubMed ID: 12028533	2002
Defining antigen-specific responses with human MHC class II tetramers. The Journal of allergy and clinical immunology\| PubMed ID: 12170258	2002
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. The Journal of experimental medicine\| PubMed ID: 12208877	2002
Use of class II tetramers for identification of CD4+ T cells. Journal of immunological methods\| PubMed ID: 12213344	2002
Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12538679	2003
HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells. Clinical immunology (Orlando, Fla.)\| PubMed ID: 12584046	2003
Challenges in staining T cells using HLA class II tetramers. Clinical immunology (Orlando, Fla.)\| PubMed ID: 12584047	2003
Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes. Methods (San Diego, Calif.)\| PubMed ID: 12725793	2003
Low-avidity recognition by CD4+ T cells directed to self-antigens. European journal of immunology\| PubMed ID: 12731068	2003
P53(110-124)-specific human CD4+ T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8+ T cells. Cancer research\| PubMed ID: 12839958	2003
HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12960344	2003
Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. Journal of virology\| PubMed ID: 14512540	2003
Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1. Blood\| PubMed ID: 14563644	2004
Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers. Annals of the New York Academy of Sciences\| PubMed ID: 14679042	2003
HLA class II polymorphisms determine responses to bacterial superantigens. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14734754	2004
Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells. Diabetes\| PubMed ID: 15047612	2004
Autoreactive T cells in healthy individuals. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15128778	2004
Extensive replicative capacity of human central memory T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15153483	2004
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes\| PubMed ID: 15277377	2004
In vivo biotinylation of the major histocompatibility complex (MHC) class II/peptide complex by coexpression of BirA enzyme for the generation of MHC class II/tetramers. Human immunology\| PubMed ID: 15301857	2004
Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2. The Journal of infectious diseases\| PubMed ID: 15609235	2005
Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15749850	2005
Functional avidity directs T-cell fate in autoreactive CD4+ T cells. Blood\| PubMed ID: 16030184	2005
Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells. Human immunology\| PubMed ID: 16112025	2005
Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells. Journal of clinical immunology\| PubMed ID: 16160911	2005
Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells. International immunology\| PubMed ID: 16221722	2005
The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells. European journal of immunology\| PubMed ID: 16245362	2005
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects. Journal of autoimmunity\| PubMed ID: 16249070	2005
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. Journal of autoimmunity\| PubMed ID: 16263242	2005
Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16424231	2006
Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601. Immunology\| PubMed ID: 16476054	2006
Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16493034	2006
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide. The Journal of experimental medicine\| PubMed ID: 16585267	2006
Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585604	2006
Multiplex mapping of CD4 T cell epitopes using class II tetramers. Clinical immunology (Orlando, Fla.)\| PubMed ID: 16677863	2006
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. The Journal of clinical investigation\| PubMed ID: 16878175	2006
Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17082590	2006
Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers. Clinical immunology (Orlando, Fla.)\| PubMed ID: 17113829	2007
CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65. European journal of immunology\| PubMed ID: 17163450	2007
Antigen-specific CD4+ T cells recognize epitopes of protective antigen following vaccination with an anthrax vaccine. Infection and immunity\| PubMed ID: 17283103	2007
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy. The Journal of allergy and clinical immunology\| PubMed ID: 17335888	2007
Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17475867	2007
Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis. Molecular immunology\| PubMed ID: 17555819	2008
Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition. International immunology\| PubMed ID: 17906339	2007
Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractor... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17947711	2007
Tracking antigen specific CD4+ T-cells with soluble MHC molecules. Methods in molecular medicine\| PubMed ID: 17983139	2007
High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. Journal of virology\| PubMed ID: 18160439	2008
Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis. Molecular immunology\| PubMed ID: 18191206	2008
Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18209073	2008
Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling. Molecular immunology\| PubMed ID: 18276010	2008
Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. Journal of virology\| PubMed ID: 18337568	2008
CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope. Journal of autoimmunity\| PubMed ID: 18385016	2008
Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes. Diabetes\| PubMed ID: 18586912	2008
The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells. Infection and immunity\| PubMed ID: 18678674	2008
Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals. International immunology\| PubMed ID: 19050106	2009
Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects. European journal of immunology\| PubMed ID: 19180473	2009
H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4. Vaccine\| PubMed ID: 19446935	2009
Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses. Blood\| PubMed ID: 19549986	2009
The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19648278	2009
Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts. Cancer research\| PubMed ID: 19808957	2009
Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation. European journal of immunology\| PubMed ID: 19830726	2010
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus. Journal of virology\| PubMed ID: 20071564	2010
Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells. European journal of immunology\| PubMed ID: 20101615	2010
HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity. PLoS pathogens\| PubMed ID: 20195518	2010
Direct ex vivo analysis of allergen-specific CD4+ T cells. The Journal of allergy and clinical immunology\| PubMed ID: 20513526	2010
HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets. Arthritis and rheumatism\| PubMed ID: 20533291	2010
Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses. PloS one\| PubMed ID: 20634998	2010
Allergen-specific naÃ¯ve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy. European journal of immunology\| PubMed ID: 20690179	2010
Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis. Hepatology (Baltimore, Md.)\| PubMed ID: 21190158	2010
Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes. Journal of autoimmunity\| PubMed ID: 21257290	2011
Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis. Hepatology (Baltimore, Md.)\| PubMed ID: 21274874	2011
Ara h 1-reactive T cells in individuals with peanut allergy. The Journal of allergy and clinical immunology\| PubMed ID: 21459424	2011
Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21531896	2011
Autoreactive CD4(+) T cells in patients with atopic dermatitis. The Journal of allergy and clinical immunology\| PubMed ID: 21620451	2011
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21653833	2011
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21765017	2011
Human CD8âº and CD4âº T cell memory to lymphocytic choriomeningitis virus infection. Journal of virology\| PubMed ID: 21900169	2011
Differentiation stage determines pathologic and protective allergen-specific CD4(+) T-cell outcomes during specific immunotherapy. The Journal of allergy and clinical immunology\| PubMed ID: 21975176	2012
Induction and maintenance of allergen-specific FOXP3(+) Treg cells in human tonsils as potential first-line organs of oral tolerance. The Journal of allergy and clinical immunology\| PubMed ID: 22051696	2012
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS pathogens\| PubMed ID: 22144893	2011
DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9. Molecular immunology\| PubMed ID: 22196942	2012
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. The Journal of experimental medicine\| PubMed ID: 22213804	2012
Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22327072	2012