Sangeeta N. Bhatia

Quantum dots to monitor RNAi delivery and improve gene silencing.

Proteolytic actuation of nanoparticle self-assembly.

Local heating of discrete droplets using magnetic porous silicon-based photonic crystals.

Engineering tissues for in vitro applications.

Assessment of hepatocellular function within PEG hydrogels.

Microscale control of cell contact and spacing via three-component surface patterning.

Micromechanical control of cell-cell interactions.

Multiphase electropatterning of cells and biomaterials.

High-throughput analysis of signals regulating stem cell fate and function.

Microscale culture of human liver cells for drug development.

T-cadherin modulates hepatocyte functions in vitro.

Protease-triggered unveiling of bioactive nanoparticles.

Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.

Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.

Statistical dynamics of flowing red blood cells by morphological image processing.

Biodegradable luminescent porous silicon nanoparticles for in vivo applications.

Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.

Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas.

Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro.

Tissue-specific gene delivery via nanoparticle coating.

Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents.

Cooperative nanomaterial system to sensitize, target, and treat tumors.

Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system.

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.

SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating.

Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery.

Targeting of drugs and nanoparticles to tumors.

Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics.

Single cell trapping and DNA damage analysis using microwell arrays.

Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting.

Multiplexed, high-throughput analysis of 3D microtissue suspensions.

Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.

In-silico patterning of vascular mesenchymal cells in three dimensions.

Nanoparticles that communicate in vivo to amplify tumour targeting.

Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging.

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

Humanized mice with ectopic artificial liver tissues.

DNA-templated assembly of droplet-derived PEG microtissues.

Modeling hepatitis C virus infection using human induced pluripotent stem cells.

A biophysical indicator of vaso-occlusive risk in sickle cell disease.

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues.

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4.

Cancer vulnerabilities unveiled by genomic loss.

Identification and characterization of receptor-specific peptides for siRNA delivery.

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis.

Bioengineering methods for analysis of cells in vitro.

Genetic Circuits in Salmonella typhimurium.

In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria.

Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.

Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.

Geometric control of vascular networks to enhance engineered tissue integration and function.

Mitochondrial localization and the persistent migration of epithelial cancer cells.

Identification of small molecules for human hepatocyte expansion and iPS differentiation.

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.

Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source.

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.

Nanotechnology: emerging tools for biology and medicine.

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.

Weighing nanoparticles in solution at the attogram scale.

Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues.

Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics.

A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors.

Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology.

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.

Microfluidic organs-on-chips.

Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.

Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.

Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes.

Patterning vascular networks in vivo for tissue engineering applications.

In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.

Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche.

Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection.

Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro.

Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering.

New Methods in Tissue Engineering: Improved Models for Viral Infection.

Programmable probiotics for detection of cancer in urine.

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

A Macro-to-Micro Interface for the Control of Cellular Organization.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Mathematical framework for activity-based cancer biomarkers.

Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

Smart nanosystems: Bio-inspired technologies that interact with the host environment.

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries.

Synchronized cycles of bacterial lysis for in vivo delivery.

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.

Host AMPK Is a Modulator of Plasmodium Liver Infection.

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling.

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.

Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections.

In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

Ultrasensitive tumour-penetrating nanosensors of protease activity.

Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas.

A robust cell culture system supporting the complete life cycle of hepatitis B virus.

Depolarization signatures map gold nanorods within biological tissue.

Engineered Livers for Infectious Diseases.

Personalized RNA Medicine for Pancreatic Cancer.

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts.

Drug-induced amplification of nanoparticle targeting to tumors.

Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages.

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer.

iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer.

Classification of prostate cancer using a protease activity nanosensor library.

A sporozoite-based vaccination platform against human malaria.

Protease activity sensors noninvasively classify bacterial infections and antibiotic responses.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes.

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles.

Antimalarial activity of primaquine operates via a two-step biochemical relay.

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring.

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer.

Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes.

Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.

Targeting liver stage malaria with metformin.

Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.

Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging.

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma.

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.

Activity-Based Diagnostics: An Emerging Paradigm for Disease Detection and Monitoring.

Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines.

Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics.

Engineering synthetic breath biomarkers for respiratory disease.

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination.

Peptide Spiders: Peptide-Polymer Conjugates to Traffic Nucleic Acids.

Activatable Zymography Probes Enable Localization of Protease Dysregulation in Cancer.

Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues.

Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization.

Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers.

Opening the path to biotech.

Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity.

Microenvironment-triggered multimodal precision diagnostics.

Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function.

Synthetic Circuit-Driven Expression of Heterologous Enzymes for Disease Detection.

Synthetic biomarkers: a twenty-first century path to early cancer detection.

Distinct Hepatic Gene-Expression Patterns of NAFLD in Patients With Obesity.

Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis.

Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds.

Ionic Liquid-Mediated Transdermal Delivery of Thrombosis-Detecting Nanosensors.

Virtual Undergraduate Research Experiences: More Than a Pandemic Stopgap.

A single-cell liver atlas of Plasmodium vivax infection.

Host protease activity classifies pneumonia etiology.

A vascularized model of the human liver mimics regenerative responses.

Cancer nanomedicine.

Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer.

Conditional Antimicrobial Peptide Therapeutics.

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes.

Multiscale profiling of protease activity in cancer.

Low protease activity in B cell follicles promotes retention of intact antigens after immunization.

CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics.

Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer.