Visceral Surgery and Precision Medicine Research Laboratory,
Department of Biomedicine,
Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine
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TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.
PloS one , 2010 | Pubmed ID: 21179245
MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies.
International journal of cancer Sep, 2011 | Pubmed ID: 21710496
HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma.
Histopathology Feb, 2012 | Pubmed ID: 22276603
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.
Hepatology (Baltimore, Md.) Mar, 2014 | Pubmed ID: 24114970
3'-UTR poly(T/U) tract deletions and altered expression of EWSR1 are a hallmark of mismatch repair-deficient cancers.
Cancer research Jan, 2014 | Pubmed ID: 24158095
SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules.
European journal of cancer (Oxford, England : 1990) Mar, 2014 | Pubmed ID: 24315626
High-resolution breakpoint analysis provides evidence for the sequence-directed nature of genome rearrangements in hereditary disorders.
Human mutation Feb, 2015 | Pubmed ID: 25418510
HMGA1 overexpression is associated with a particular subset of human breast carcinomas.
Journal of clinical pathology Feb, 2016 | Pubmed ID: 26251519
HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models.
Neoplasia (New York, N.Y.) Dec, 2016 | Pubmed ID: 27855356
High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy.
Molecular carcinogenesis Sep, 2017 | Pubmed ID: 28467612
Molecular classification of hepatocellular carcinoma: The view from metabolic zonation.
Hepatology (Baltimore, Md.) Nov, 2017 | Pubmed ID: 28599064
Diverse and Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2017 | Pubmed ID: 28765325
NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.
Bioinformatics (Oxford, England) Jan, 2018 | Pubmed ID: 28968639
Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways.
NPJ breast cancer , 2017 | Pubmed ID: 29043292
Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.
Cell death & disease Oct, 2017 | Pubmed ID: 29072691
Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast.
NPJ breast cancer , 2017 | Pubmed ID: 29214215
Genomic Analysis Revealed New Oncogenic Signatures in -Mutant Hepatocellular Carcinoma.
Frontiers in genetics , 2018 | Pubmed ID: 29456550
The Role of Long Non-Coding RNAs in Hepatocarcinogenesis.
International journal of molecular sciences Feb, 2018 | Pubmed ID: 29495592
The protein histidine phosphatase LHPP is a tumour suppressor.
Nature Mar, 2018 | Pubmed ID: 29562234
Circulating Cell-Free DNA in Hepatocellular Carcinoma: Current Insights and Outlook.
Frontiers in medicine , 2018 | Pubmed ID: 29632864
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas.
Nature communications May, 2018 | Pubmed ID: 29739933
Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations.
Diagnostics (Basel, Switzerland) May, 2018 | Pubmed ID: 29747380
Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases.
Oncotarget Apr, 2018 | Pubmed ID: 29755676
Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies.
Cell reports Jul, 2018 | Pubmed ID: 30067989
Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening.
The Journal of molecular diagnostics : JMD Nov, 2018 | Pubmed ID: 30142445
Lobular Carcinomas Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2019 | Pubmed ID: 30185420
Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity.
Cell reports Nov, 2018 | Pubmed ID: 30404001
Fibroepithelial Breast Lesion: When Sequencing Can Help to Make a Clinical Decision. A Case Report.
Clinical breast cancer Feb, 2019 | Pubmed ID: 30470624
Therapeutic Targeting of CD146/MCAM Reduces Bone Metastasis in Prostate Cancer.
Molecular cancer research : MCR May, 2019 | Pubmed ID: 30745464
Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma.
Scientific reports Mar, 2019 | Pubmed ID: 30872650
Genomic characterization of metastatic breast cancers.
Nature May, 2019 | Pubmed ID: 31118521
PipeIT: A Singularity Container for Molecular Diagnostic Somatic Variant Calling on the Ion Torrent Next-Generation Sequencing Platform.
The Journal of molecular diagnostics : JMD Sep, 2019 | Pubmed ID: 31229654
Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer.
Breast cancer research and treatment Oct, 2019 | Pubmed ID: 31267330
Author Correction: Genomic characterization of metastatic breast cancers.
Nature Aug, 2019 | Pubmed ID: 31308536
Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors.
Hepatology communications Jul, 2019 | Pubmed ID: 31334445
Nectin-4 Expression Is an Independent Prognostic Biomarker and Associated With Better Survival in Triple-Negative Breast Cancer.
Frontiers in medicine , 2019 | Pubmed ID: 31572728
Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification.
BMC cancer Dec, 2019 | Pubmed ID: 31842810
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Nature communications Dec, 2019 | Pubmed ID: 31848340
Hormone receptor and HER2 assessment in breast carcinoma metastatic to bone: A comparison between FNA cell blocks and decalcified core needle biopsies.
Cancer cytopathology Feb, 2020 | Pubmed ID: 31883437
Corrigendum to "HMGA1 expression in human hepatocellular carcinoma correlates with poor prognosis and promotes tumor growth and migration in in vitro models" [Neoplasia 18 (2016) 724-731].
Neoplasia (New York, N.Y.) Jul, 2020 | Pubmed ID: 32438307
A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.
Cancer research Sep, 2020 | Pubmed ID: 32586983
Reliability of liquid biopsy analysis: an inter-laboratory comparison of circulating tumor DNA extraction and sequencing with different platforms.
Laboratory investigation; a journal of technical methods and pathology Nov, 2020 | Pubmed ID: 32616816
Identification of Somatic Mutations in Thirty-year-old Serum Cell-free DNA From Patients With Breast Cancer: A Feasibility Study.
Clinical breast cancer Oct, 2020 | Pubmed ID: 32650988
High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes.
Frontiers in oncology , 2020 | Pubmed ID: 32733792
Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation.
The EMBO journal Sep, 2020 | Pubmed ID: 32812257
Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer.
Cancer immunology research Nov, 2020 | Pubmed ID: 32839156
The genetic landscape of metaplastic breast cancers and uterine carcinosarcomas.
Molecular oncology Apr, 2021 | Pubmed ID: 33021035
Deciphering the clonal relationship between glandular and squamous components in adenosquamous carcinoma of the lung using whole exome sequencing.
Lung cancer (Amsterdam, Netherlands) Dec, 2020 | Pubmed ID: 33137577
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity.
Nature communications Nov, 2020 | Pubmed ID: 33144576
Prognostic significance of CD8+ T-cells density in stage III colorectal cancer depends on SDF-1 expression.
Scientific reports Jan, 2021 | Pubmed ID: 33436863
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications Feb, 2021 | Pubmed ID: 33602919
Nestin and CD34 expression in colorectal cancer predicts improved overall survival.
Acta oncologica (Stockholm, Sweden) Jun, 2021 | Pubmed ID: 33734917
Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis.
Theranostics , 2021 | Pubmed ID: 33754045
Genomic characterization of small cell carcinomas of the uterine cervix.
Molecular oncology Feb, 2022 | Pubmed ID: 33830625
Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo-Independent Regulation of Heat Shock Protein 70 Family Members.
Hepatology communications Apr, 2021 | Pubmed ID: 33860124
Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma.
Journal of controlled release : official journal of the Controlled Release Society Jun, 2021 | Pubmed ID: 33894304
Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens.
The Journal of pathology Aug, 2021 | Pubmed ID: 33934365
Genomic evolutionary trajectory of metastatic squamous cell carcinoma of the lung.
Translational lung cancer research Apr, 2021 | Pubmed ID: 34012793
Mapping of mA and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance.
Molecular cancer research : MCR Aug, 2021 | Pubmed ID: 34088870
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
Cell stem cell Oct, 2021 | Pubmed ID: 34129813
USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis.
Oncogenesis Jul, 2021 | Pubmed ID: 34272356
Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens.
Nucleic acids research Sep, 2021 | Pubmed ID: 34313788
mTOR signaling mediates ILC3-driven immunopathology.
Mucosal immunology Nov, 2021 | Pubmed ID: 34341503
Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma.
BMC genomics Aug, 2021 | Pubmed ID: 34348664
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis.
EMBO molecular medicine Dec, 2021 | Pubmed ID: 34664408
High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival.
Cancers Nov, 2021 | Pubmed ID: 34830938
Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma.
Molecular oncology Feb, 2022 | Pubmed ID: 34863035
Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues.
Frontiers in oncology , 2021 | Pubmed ID: 35083141
miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver.
Hepatology communications Jun, 2022 | Pubmed ID: 35132819
Circulating Cell-Free DNA Captures the Intratumor Heterogeneity in Multinodular Hepatocellular Carcinoma.
JCO precision oncology Mar, 2022 | Pubmed ID: 35263170
Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T.
Circulation Jun, 2022 | Pubmed ID: 35389756
GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers.
Communications biology Apr, 2022 | Pubmed ID: 35440675
Alterations in homologous recombination repair genes in prostate cancer brain metastases.
Nature communications May, 2022 | Pubmed ID: 35504881
Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.
Nature communications May, 2022 | Pubmed ID: 35508466
Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report.
Communications medicine , 2022 | Pubmed ID: 35603298
Author Correction: GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers.
Communications biology Jul, 2022 | Pubmed ID: 35787660
Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report.
Communications medicine , 2022 | Pubmed ID: 35789568
The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples.
Cancers Jun, 2022 | Pubmed ID: 35804847
The Role of Chronic Liver Diseases in the Emergence and Recurrence of Hepatocellular Carcinoma: An Omics Perspective.
Frontiers in medicine , 2022 | Pubmed ID: 35814741
Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.
Nature communications Aug, 2022 | Pubmed ID: 35987910
Response by du Fay de Lavallaz et al to Letter Regarding Article, "Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T".
Circulation Oct, 2022 | Pubmed ID: 36214135
Live slow-frozen human tumor tissues viable for 2D, 3D, ex vivo cultures and single-cell RNAseq.
Communications biology Oct, 2022 | Pubmed ID: 36307545
The prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on CD8+ density.
BMC endocrine disorders Nov, 2022 | Pubmed ID: 36419107
Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens.
Nature communications Dec, 2022 | Pubmed ID: 36517508
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition.
Science advances Feb, 2023 | Pubmed ID: 36724278
DNA Methylation Landscapes of Prostate Cancer Brain Metastasis Are Shaped by Early Driver Genetic Alterations.
Cancer research Apr, 2023 | Pubmed ID: 36749655
PipeIT2: A tumor-only somatic variant calling workflow for molecular diagnostic Ion Torrent sequencing data.
Genomics Mar, 2023 | Pubmed ID: 36796655
PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer.
Journal of mammary gland biology and neoplasia Jun, 2023 | Pubmed ID: 37294349
Minor intron splicing is critical for survival of lethal prostate cancer.
Molecular cell Jun, 2023 | Pubmed ID: 37295433
Cylindroma of the breast with CYLD gene mutation: a case report and review of the literature.
Molecular biology reports Aug, 2023 | Pubmed ID: 37389703
Early Age of Onset Is an Independent Predictor for a Worse Response to Neoadjuvant Therapies in Sporadic Rectal Cancer Patients.
Cancers Jul, 2023 | Pubmed ID: 37509411
Colitis Is Associated with Loss of the Histidine Phosphatase LHPP and Upregulation of Histidine Phosphorylation in Intestinal Epithelial Cells.
Biomedicines Aug, 2023 | Pubmed ID: 37626656
Arginine reprograms metabolism in liver cancer via RBM39.
Cell Nov, 2023 | Pubmed ID: 37804830
Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer.
NPJ precision oncology Nov, 2023 | Pubmed ID: 37919480
High density of CXCL12-positive immune cell infiltration predicts chemosensitivity and recurrence-free survival in ovarian carcinoma.
Journal of cancer research and clinical oncology Dec, 2023 | Pubmed ID: 37966614
Fragment-sequencing unveils local tissue microenvironments at single-cell resolution.
Nature communications Nov, 2023 | Pubmed ID: 38012149
Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids.
Nature biomedical engineering Dec, 2023 | Pubmed ID: 38114742
Cell-Free DNA Genomic Profiling and Its Clinical Implementation in Advanced Prostate Cancer.
Cancers Dec, 2023 | Pubmed ID: 38201475
Fabian Haak*,1,
Gabriel Fridolin Hess*,1,
Philipp Sedlaczek1,
Savas Deniz Soysal2,
Jürg Vosbeck3,
Salvatore Piscuoglio4,5,
Mairene Coto-Llerena*,4,
Otto Kollmar*,1
1Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel,
2Faculty of Medicine, University of Basel,
3Institute of Medical Genetics and Pathology, University Hospital Basel,
4Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel,
5, IRCCS Humanitas Research Hospital
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