Larry A. Sklar

Center for Molecular Discovery, University of New Mexico Health Sciences Center

Affiliated withUniversity of New Mexico Health Sciences Center University of New Mexico

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2024

Other Publications

Article	Year
Solubilization and display of G protein-coupled receptors on beads for real-time fluorescence and flow cytometric analysis. BioTechniques\| PubMed ID: 10818705	2000
Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annual review of biophysics and biomolecular structure\| PubMed ID: 11988464	2002
Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening. Current opinion in pharmacology\| PubMed ID: 17652026	2007
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. The Journal of biological chemistry\| PubMed ID: 23382385	2013
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters. Analytical biochemistry\| PubMed ID: 23470221	2013
The University of New Mexico Center for Molecular Discovery. Combinatorial chemistry & high throughput screening\| PubMed ID: 24409953	2014
Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PloS one\| PubMed ID: 24804769	2014
A high throughput flow cytometric assay platform targeting transporter inhibition. Drug discovery today. Technologies\| PubMed ID: 25027381	2014
FRET detection of lymphocyte function-associated antigen-1 conformational extension. Molecular biology of the cell\| PubMed ID: 25378583	2015
Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. Journal of biomolecular screening\| PubMed ID: 26442911	2016
Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PloS one\| PubMed ID: 26558612	2015
Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia. Oncotarget\| PubMed ID: 27129155	2016
A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3',5'-Cyclic Adenosine Monophosphate Efflux. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27316999	2016
High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining. SLAS discovery : advancing life sciences R & D\| PubMed ID: 29232168	2018
Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy\| PubMed ID: 29938597	2018
Clioquinol: To harm or heal. Pharmacology & therapeutics\| PubMed ID: 30898518	2019
Autophagy, Inflammation, and Metabolism (AIM) Center in its second year. Autophagy\| PubMed ID: 31234750	2019
A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling. Cell chemical biology\| PubMed ID: 31706983	2019
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy. Cell reports\| PubMed ID: 32049011	2020
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. Journal of medicinal chemistry\| PubMed ID: 32902275	2020
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia. The Journal of clinical investigation\| PubMed ID: 33555272	2021
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions. SLAS discovery : advancing life sciences R & D\| PubMed ID: 35385793	2022