examination-oral-candida-infection-primary-sjgren-s-syndrome

Examination of Oral <i>Candida</i> Infection in Primary Sj&#246;gren&#39;s Syndrome Patients

Primary Sj&#246;gren's syndrome (pSS) is an autoimmune disease characterized by symptoms such as dry mouth, dry eyes, and other systematic symptoms. Due ...

Capital Medical University

NMPA

Beijing Engineering Research Center of Immunological Reagents Clinical Research

Current laboratory examinations for hypercoagulable diseases focus on the biomarker content of the activated coagulation cascade and fibrinolytic system. Direct detection of physiologically important protease activities in blood remains a challenge. This study aims to develop a general approach that enables the determination of activities of crucial coagulation factors and plasmin in blood.

Direct Determination of Coagulation Factor IIa and Plasmin Activities for Monitoring of Thrombotic State.

 is one of the most commonly isolated species from human skin and the second leading cause of bloodstream infections. Here, we performed a large-scale comparative study without any pre-assigned reference to identify genomic determinants associated with the diversity and adaptation of  strains to various environments. Pan-genome of  was open with 435 core proteins and had a pan-genome size of 8,034 proteins. Genome-wide phylogenetic tree showed high heterogeneity and suggested that routine whole genome sequencing was a powerful tool for analyzing the complex evolution of .  and for investigating the infection sources. Comparative genome analyses demonstrated a range of antimicrobial resistance (AMR) genes, especially those within mobile genetic elements. The complicated host-bacterium and bacterium-bacterium relationships help .  to play a vital role in balancing the epithelial microflora. The highly variable and dynamic nature of the  genome may contribute to its success in adapting to broad habitats. Genes related to biofilm formation and cell toxicity were significantly enriched in the blood and skin, demonstrating their potentials in identifying risk genotypes. This study gave a general landscape of  pan-genome and provided valuable insights into mechanisms for genome evolution and lifestyle adaptation of this ecologically flexible species.

Comparative Genome Analysis Reveals the Molecular Basis of Niche Adaptation of  Strains.

To analyze the differences in laboratory data between patients with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).

Article	Year
Direct Determination of Coagulation Factor IIa and Plasmin Activities for Monitoring of Thrombotic State. The journal of applied laboratory medicine\| PubMed ID: 32529225	2020
Comparative Genome Analysis Reveals the Molecular Basis of Niche Adaptation of Strains. Frontiers in genetics\| PubMed ID: 33240320	2020
A retrospective study of myelin oligodendrocyte glycoprotein antibody-associated disease from a clinical laboratory perspective. Frontiers in neurology\| PubMed ID: 37771453	2023

Bingqing Han

Biography

JoVE Journal Publications

Other Publications