Andrei V. Karginov

Phosphorylation-mediated regulation of GEFs for RhoA.

Optochemical activation of kinase function in live cells.

Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.

Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms.

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.

Characterization of an Engineered Src Kinase to Study Src Signaling and Biology.

Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae.

Mimicking transient activation of protein kinases in living cells.

Engineering Pak1 Allosteric Switches.

Dissecting Kinase Effector Signaling Using the RapRTAP Methodology.

Inhibition of Clostridium perfringens epsilon toxin by β-cyclodextrin derivatives.

Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response.

Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.

Optogenetics: The Art of Illuminating Complex Signaling Pathways.

Methods for assessment of membrane protrusion dynamics.

Förster resonance energy transfer biosensors for fluorescence and time-gated luminescence analysis of rac1 activity.

Engineered Allosteric Regulation of Protein Function.

Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity.