Scott I. Simon

Department of Biomedical Engineering

University of California, Davis

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PUBLICATIONS

Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway.

Journal of immunology (Baltimore, Md. : 1950) Apr, 2000 | Pubmed ID: 10754335

Laboratory investigation; a journal of technical methods and pathology Mar, 2002 | Pubmed ID: 11896209

The Journal of biological chemistry Jun, 2002 | Pubmed ID: 11929876

Leukocyte adhesion dynamics in shear flow.

Annals of biomedical engineering Mar, 2002 | Pubmed ID: 12051617

American journal of physiology. Cell physiology Mar, 2003 | Pubmed ID: 12431911

Hydrodynamic shear and tethering through E-selectin signals phosphorylation of p38 MAP kinase and adhesion of human neutrophils.

Annals of biomedical engineering Sep, 2002 | Pubmed ID: 12449760

Blood Apr, 2003 | Pubmed ID: 12480703

Inflammatory potential of neutrophils detected in sickle cell disease.

American journal of hematology Jun, 2004 | Pubmed ID: 15164377

Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils.

Journal of immunology (Baltimore, Md. : 1950) Jun, 2004 | Pubmed ID: 15187162

Annals of biomedical engineering Sep, 2004 | Pubmed ID: 15493506

American journal of physiology. Cell physiology Aug, 2005 | Pubmed ID: 15788481

Mathematical biosciences Mar, 2005 | Pubmed ID: 15836865

The Journal of biological chemistry Aug, 2005 | Pubmed ID: 15955822

Molecular mechanics and dynamics of leukocyte recruitment during inflammation.

Annual review of biomedical engineering , 2005 | Pubmed ID: 16004569

Blood Mar, 2006 | Pubmed ID: 16269618

Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles.

Journal of controlled release : official journal of the Controlled Release Society Mar, 2006 | Pubmed ID: 16380187

CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions.

American journal of physiology. Heart and circulatory physiology Sep, 2006 | Pubmed ID: 16603696

Immunity Aug, 2006 | Pubmed ID: 16901726

Molecular imaging Jul, 2006 | Pubmed ID: 16954028

Circulation research Feb, 2007 | Pubmed ID: 17234968

Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer.

Annals of biomedical engineering Apr, 2007 | Pubmed ID: 17370125

Mechanisms of B-cell synapse formation predicted by Monte Carlo simulation.

Biophysical journal Jun, 2007 | Pubmed ID: 17384077

Journal of leukocyte biology Jun, 2007 | Pubmed ID: 17389580

Vascular mimetics based on microfluidics for imaging the leukocyte--endothelial inflammatory response.

Lab on a chip Apr, 2007 | Pubmed ID: 17389960

Journal of cellular physiology Feb, 2008 | Pubmed ID: 17676580

Journal of leukocyte biology Jan, 2008 | Pubmed ID: 17928459

Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging.

The Journal of investigative dermatology Jul, 2008 | Pubmed ID: 18185533

SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.

European journal of immunology Feb, 2008 | Pubmed ID: 18196517

Annals of biomedical engineering Apr, 2008 | Pubmed ID: 18253835

Annals of biomedical engineering Apr, 2008 | Pubmed ID: 18278555

Annals of biomedical engineering Apr, 2008 | Pubmed ID: 18317931

Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 18453113

Microcirculation (New York, N.Y. : 1994) May, 2008 | Pubmed ID: 18464160

Blood Nov, 2008 | Pubmed ID: 18948585

Leucocyte recruitment under fluid shear: mechanical and molecular regulation within the inflammatory synapse.

Clinical and experimental pharmacology & physiology Feb, 2009 | Pubmed ID: 19018799

Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.

Journal of immunology (Baltimore, Md. : 1950) Dec, 2008 | Pubmed ID: 19050286

Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding.

American journal of physiology. Cell physiology Apr, 2009 | Pubmed ID: 19176758

Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia.

Circulation May, 2009 | Pubmed ID: 19433759

Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature.

Journal of immunology (Baltimore, Md. : 1950) Jun, 2009 | Pubmed ID: 19454683

Cancer research Dec, 2009 | Pubmed ID: 19934331

Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow.

Blood Jan, 2010 | Pubmed ID: 19965684

A day (or 5) in a neutrophil's life.

Blood Jul, 2010 | Pubmed ID: 20671133

Mightier than the sickle cell.

Blood Sep, 2010 | Pubmed ID: 20829378

A mouse model of post-arthroplasty Staphylococcus aureus joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings.

PloS one , 2010 | Pubmed ID: 20830204

Arteriosclerosis, thrombosis, and vascular biology Jan, 2011 | Pubmed ID: 21030716

American journal of physiology. Heart and circulatory physiology Mar, 2011 | Pubmed ID: 21169396

The Journal of investigative dermatology Apr, 2011 | Pubmed ID: 21191403

Neutrophil survival and c-kit(+)-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution.

Blood Mar, 2011 | Pubmed ID: 21278352

Functional characterization of embryonic stem cell-derived endothelial cells.

Journal of vascular research , 2011 | Pubmed ID: 21625175

Migrational guidance of neutrophils is mechanotransduced via high-affinity LFA-1 and calcium flux.

Journal of immunology (Baltimore, Md. : 1950) Jul, 2011 | Pubmed ID: 21632714

Biochemical and biophysical research communications Jul, 2011 | Pubmed ID: 21683067

Journal of neurophysiology Jun, 2012 | Pubmed ID: 22402651

Bone marrow research , 2012 | Pubmed ID: 22762001

Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest.

Frontiers in immunology , 2012 | Pubmed ID: 22787461

IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal.

Circulation research Sep, 2012 | Pubmed ID: 22874466

Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.

PLoS pathogens , 2012 | Pubmed ID: 23209417

On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction.

Proceedings of the National Academy of Sciences of the United States of America Aug, 2013 | Pubmed ID: 23918401

Clocking leukocytes reveal dynamics of integrin braking.

Biophysical journal Sep, 2013 | Pubmed ID: 24010651

Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress.

PloS one , 2013 | Pubmed ID: 24205197

Coronary artery endothelial cells and microparticles increase expression of VCAM-1 in myocardial infarction.

Thrombosis and haemostasis Mar, 2015 | Pubmed ID: 25413339

Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo.

Nature communications Mar, 2015 | Pubmed ID: 25824568

CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia.

Journal of immunology (Baltimore, Md. : 1950) Dec, 2015 | Pubmed ID: 26519532

Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation.

Nature communications Nov, 2015 | Pubmed ID: 26612263

Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus.

Frontiers in immunology , 2015 | Pubmed ID: 26635795

Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids.

Stem cells (Dayton, Ohio) 06, 2017 | Pubmed ID: 28276602

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Infected Wounds.

Journal of immunology (Baltimore, Md. : 1950) 09, 2017 | Pubmed ID: 28733486

Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow.

Blood 11, 2017 | Pubmed ID: 28811304

Neutrophils in hot pursuit of MRSA in the lymph nodes.

Proceedings of the National Academy of Sciences of the United States of America 03, 2018 | Pubmed ID: 29476009

Is CCR6 Required for the Development of Psoriasiform Dermatitis in Mice?

The Journal of investigative dermatology Feb, 2019 | Pubmed ID: 30193756

Selectin-Targeting Peptide-Glycosaminoglycan Conjugates Modulate Neutrophil-Endothelial Interactions.

Cellular and molecular bioengineering , 2019 | Pubmed ID: 30740185

INSTITUTIONS

University of California, Davis

University of California Davis

JOVE ARTICLES

On-Chip Endothelial Inflammatory Phenotyping

J. Sherrod DeVerse^*,1,

Keith A. Bailey^*,1,

Greg A. Foster¹,

Vaishali Mittal¹,

Stuart M. Altman¹,

Scott I. Simon¹,

Anthony G. Passerini¹

¹Department of Biomedical Engineering, University of California, Davis

Bioengineering

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Leif S. Anderson¹,

Mack B. Reynolds¹,

Kathryn R. Rivara¹,

Lloyd S. Miller²,

Scott I. Simon¹

¹Department of Biomedical Engineering, University of California Davis,

²Department of Dermatology, Johns Hopkins University School of Medicine

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Scott I. Simon

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Biomedical Engineering

University of California, Davis

On-Chip Endothelial Inflammatory Phenotyping

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Department of Biomedical Engineering