Nahum Sonenberg

Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.

Remarks on the mechanism of ribosome binding to eukaryotic mRNAs.

Weak binding affinity of human 4EHP for mRNA cap analogs.

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.

Reconstitution reveals the functional core of mammalian eIF3.

Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?

Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP).

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation.

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.

The dynamics of mammalian P body transport, assembly, and disassembly in vivo.

Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation.

General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation.

Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.

Translational control of long-lasting synaptic plasticity and memory.

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.

Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.

Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons.

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

Novel translational control in Arc-dependent long term potentiation consolidation in vivo.

Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1.

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.

Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5.

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.

Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B.

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation.

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells.

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission.

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing.

Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain.

A collection of caged compounds for probing roles of local translation in neurobiology.

S6K1 plays a critical role in early adipocyte differentiation.

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.

Translational control mechanisms in long-lasting synaptic plasticity and memory.

The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice.

eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways.

Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families.

Identification of differential translation in genome wide studies.

miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.

anota: Analysis of differential translation in genome-wide studies.

mRNA helicases: the tacticians of translational control.

Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection.

An efficient system for let-7 microRNA and GW182 protein-mediated deadenylation in vitro.

Translational control by the eukaryotic ribosome.

Unique translation initiation of mRNAs-containing TISU element.

Translation initiator EIF4G1 mutations in familial Parkinson disease.

Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.

Cap and cap-binding proteins in the control of gene expression.

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.

Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death.

Functional and direct interaction between the RNA binding protein HuD and active Akt1.

PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse.

Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3.

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis.

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.

Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions.

The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase.

Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.

TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction.

Regulation of Neuronal mRNA Translation by CaM-Kinase I Phosphorylation of eIF4GII.

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

Translational homeostasis via the mRNA cap-binding protein, eIF4E.

Distinct perturbation of the translatome by the antidiabetic drug metformin.

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

The Distribution of eIF4E-Family Members across Insecta.

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

Retrospective. Aaron Shatkin (1934-2012).

Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs.

Host translation at the nexus of infection and immunity.

Autism-related deficits via dysregulated eIF4E-dependent translational control.

Toward a genome-wide landscape of translational control.

Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells.

Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory.

The mTOR pathway in hepatic malignancies.

Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio.

Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A.

Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation.

Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver.

mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex.

Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.

Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.

Distinct translational control in CD4+ T cell subsets.

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.

Pharmacological brake-release of mRNA translation enhances cognitive memory.

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling.

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Parallel measurement of dynamic changes in translation rates in single cells.

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.

Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation.

Translational control and autism-like behaviors.

Multifaceted regulation of somatic cell reprogramming by mRNA translational control.

Largen: a molecular regulator of mammalian cell size control.

Remote control of gene function by local translation.

Translational control of immune responses: from transcripts to translatomes.

Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.

Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding.

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.

Distinctive tRNA repertoires in proliferating versus differentiating cells.

MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection.

Targeting the translation machinery in cancer.

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.

The long unfinished march towards understanding microRNA-mediated repression.

Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.

G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.

Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.

Translation and cancer.

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.

Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs.

Signalling to eIF4E in cancer.

Translational control of nociception via 4E-binding protein 1.

Introduction to Translation.

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.

Translational control by 5'-untranslated regions of eukaryotic mRNAs.

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.

Diverse cap-binding properties of Drosophila eIF4E isoforms.

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.

Transcriptional induction of 4E-BP3 prolongs translation repression.

eIF2α phosphorylation controls thermal nociception.

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.

Proposing a mechanism of action for ataluren.

Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism.

A continuum of mRNP complexes in embryonic microRNA-mediated silencing.

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.

Cap-binding protein 4EHP effects translation silencing by microRNAs.

Metformin ameliorates core deficits in a mouse model of fragile X syndrome.

Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.

Translational control and the cancer cell response to stress.

The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.

Translation is actively regulated during the differentiation of CD8 effector T cells.

Epiregulin and EGFR interactions are involved in pain processing.

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

Fragile X syndrome.

Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control.

Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.

Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity.

Aminoacylation of Proteins: New Targets for the Old ARSenal.

Translational control of ERK signaling through miRNA/4EHP-directed silencing.

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.

Beyond molecular tumor heterogeneity: protein synthesis takes control.

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction.

Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.

Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

Translational Control in Cancer.

Principles of Translational Control.

Translation deregulation in human disease.

Protein Synthesis and Translational Control: A Historical Perspective.

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.

Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.

Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.

HGF-induced migration depends on the PI(3,4,5)P-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.

Dynamic interaction of poly(A)-binding protein with the ribosome.

Translational Control in Stem Cells.

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.

A threonyl-tRNA synthetase-mediated translation initiation machinery.

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.

4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia.

The Organizing Principles of Eukaryotic Ribosome Recruitment.

Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2.

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss.

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2.

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

Role of Translational Attenuation in Inherited Retinal Degeneration.

Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation.

Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.

4E-BP-Dependent Translational Control of Mediates Adipose Tissue Macrophage Inflammatory Response.

The translational landscape of ground state pluripotency.

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.

Dysregulated translational control in brain disorders: from genes to behavior.

Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition.

Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer.

Aster-C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1.

Metformin inhibits RAN translation through PKR pathway and mitigates disease in ALS/FTD mice.

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.

eIF2α controls memory consolidation via excitatory and somatostatin neurons.

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis.

Unorthodox Mechanisms to Initiate Translation Open Novel Paths for Gene Expression.

The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.

The multifaceted eukaryotic cap structure.

MNK Inhibition Sensitizes -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.

Antidepressant actions of ketamine engage cell-specific translation via eIF4E.

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission.

microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.

microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.

4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.

4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors.

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.

mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.

Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells.

Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse.

High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors.

Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs.

UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony.

Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8 T Cell Proliferation.

Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation.

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation.

The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.

TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with mRNA.

Evolution of naturally arising SARS-CoV-2 defective interfering particles.

Recollections - Dr. Yasuhiro Furuichi.

Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.

Therapeutic targeting of eukaryotic initiation factor (eIF) 4E.

Microfluidic Wound-Healing Assay for ECM and Microenvironment Properties on Microglia BV2 Cells Migration.

Messenger RNA Translation Defects in Neurodegenerative Diseases.

MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach.

Messenger RNA Translation Defects in Neurodegenerative Diseases. Reply.

The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory.

Clinical, neuroradiological, and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder.

p38γ and p38δ modulate innate immune response by regulating MEF2D activation.

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.

The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression.

Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis.

mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development: Novel Variants, Topographic Mapping, and Clinical Outcomes.

Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease.

4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling.

C8ORF88: A Novel eIF4E-Binding Protein.

mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory.

Functional analysis of the AUG initiator codon context reveals novel conserved sequences that disfavor mRNA translation in eukaryotes.

Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells.

Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation.

The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.

Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction.

Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology.

The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner.

PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation.

MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction.

Microfluidic Wound-Healing Assay for Comparative Study on Fluid Dynamic, Chemical and Mechanical Wounding on Microglia BV2 Migration.