inducing-long-term-plasticity-intrinsic-neuronal-excitability-neurons

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

The dorsal lateral geniculate nucleus (dLGN) has long been held to act as a basic relay for visual information traveling from the retina to cortical ...

Aix-Marseille University

In the mammalian brain, synaptic transmission usually depends on presynaptic action potentials (APs) in an all-or-none (or digital) manner. Recent studies suggest, however, that subthreshold depolarization in the presynaptic cell facilitates spike-evoked transmission, thus creating an analogue modulation of a digital process (or analogue-digital (AD) modulation). At most synapses, this process is slow and not ideally suited for the fast dynamics of neural networks. We show here that transmission at CA3-CA3 and L5-L5 synapses can be enhanced by brief presynaptic hyperpolarization such as an inhibitory postsynaptic potential (IPSP). Using dual soma-axon patch recordings and live imaging, we find that this hyperpolarization-induced AD facilitation (h-ADF) is due to the recovery from inactivation of Nav channels controlling AP amplitude in the axon. Incorporated in a network model, h-ADF promotes both pyramidal cell synchrony and gamma oscillations. In conclusion, cortical excitatory synapses in local circuits display hyperpolarization-induced facilitation of spike-evoked synaptic transmission that promotes network synchrony.

Laure Fronzaroli-Molinieres

Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS),
UMR1072,
Inserm,
Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS), UMR1072, INSERM

Aix-Marseille University

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Laure Fronzaroli-Molinieres

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS),UMR1072,Inserm,Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS), UMR1072, INSERM

Aix-Marseille University

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS),
UMR1072,
Inserm,
Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS), UMR1072, INSERM