Michael W. Traxlmayr

Integrin binding human antibody constant domains--probing the C-terminal structural loops for grafting the RGD motif.

Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast.

Directed evolution of proteins for increased stability and expression using yeast display.

Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing.

Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display.

Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc.

Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.

Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution.

Engineered IgG1-Fc--one fragment to bind them all.

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library.

Directed Evolution of Protein Thermal Stability Using Yeast Surface Display.

Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies.

Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex.

A conformation-specific ON-switch for controlling CAR T cells with an orally available drug.

Driving CARs with alternative navigation tools - the potential of engineered binding scaffolds.

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function.

Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients.

PhosphoFlowSeq - A High-throughput Kinase Activity Assay for Screening Drug Resistance Mutations in EGFR.

Affinity and Stability Analysis of Yeast Displayed Proteins.

Solving the mystery of the FMC63-CD19 affinity.

An engineering strategy to target activated EGFR with CAR T cells.

Small molecule-regulated switches to provide functional control of CAR T cells within the patient.

Protocol for engineering binding domains to recognize ligand-bound receptors by using yeast surface display.