Keenan Centre for Biomedical Research,
Li Ka Shing Knowledge Institute,
Keenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute
Laurent Brochard has not added Biography.
If you are Laurent Brochard and would like to personalize this page please email our Author Liaison for assistance.
COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?
The Lancet. Respiratory medicine Aug, 2020 | Pubmed ID: 32645311
The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline.
Intensive care medicine Dec, 2020 | Pubmed ID: 33201321
Automated detection and quantification of reverse triggering effort under mechanical ventilation.
Critical care (London, England) Feb, 2021 | Pubmed ID: 33588912
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.
Critical care (London, England) Mar, 2021 | Pubmed ID: 33726819
Guideline-directed management of COVID-19: Do's and Don'ts.
The European respiratory journal Apr, 2021 | Pubmed ID: 33766949
Abdominal Muscle Use During Spontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: A Bi-center Ultrasound Study.
Chest Oct, 2021 | Pubmed ID: 34090872
A rational approach on the use of extracorporeal membrane oxygenation in severe hypoxemia: advanced technology is not a panacea.
Annals of intensive care Jul, 2021 | Pubmed ID: 34250563
Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function.
Science translational medicine Sep, 2021 | Pubmed ID: 34524862
One-Year Readmission Following Undifferentiated Acute Hypercapnic Respiratory Failure.
COPD Dec, 2021 | Pubmed ID: 34657539
Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis.
Annals of intensive care Oct, 2021 | Pubmed ID: 34693485
How to avoid an epidemic of endotracheal tube occlusion.
The Lancet. Respiratory medicine Nov, 2021 | Pubmed ID: 34739886
The Pressure Paradox: Abdominal Compression to Detect Lung Hyperinflation in COVID-19 Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine Jan, 2022 | Pubmed ID: 34748470
Reliability of plateau pressure during patient-triggered assisted ventilation. Analysis of a multicentre database.
Journal of critical care Apr, 2022 | Pubmed ID: 34952477
Advancing Global Respiratory Health, Sleep, and Critical Care: Editorial from the New Team.
American journal of respiratory and critical care medicine Jan, 2022 | Pubmed ID: 34971340
Risks and Benefits of Ultra-Lung-Protective Invasive Mechanical Ventilation Strategies with a Focus on Extracorporeal Support.
American journal of respiratory and critical care medicine Apr, 2022 | Pubmed ID: 35044901
Setting and Titrating Positive End-Expiratory Pressure.
Chest Jun, 2022 | Pubmed ID: 35131298
Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients.
Annals of intensive care Feb, 2022 | Pubmed ID: 35150355
Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis.
American journal of respiratory and critical care medicine Jun, 2022 | Pubmed ID: 35180042
Phrenic Nerve Block and Respiratory Effort in Pigs and Critically Ill Patients with Acute Lung Injury.
Anesthesiology May, 2022 | Pubmed ID: 35348581
High flow nasal cannula improves breathing efficiency and ventilatory ratio in COPD patients recovering from an exacerbation.
Journal of critical care Jun, 2022 | Pubmed ID: 35349909
Corrigendum to "Reliability of plateau pressure during patient-triggered assisted ventilation. Analysis of a multicentre database" [Journal of Critical Care, 68 (2022) 96-103].
Journal of critical care Dec, 2022 | Pubmed ID: 35379532
External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study.
Annals of intensive care Apr, 2022 | Pubmed ID: 35412161
Physiology Is Vital to Precision Medicine in Acute Respiratory Distress Syndrome and Sepsis.
American journal of respiratory and critical care medicine Jul, 2022 | Pubmed ID: 35442864
Lung recruitment.
Intensive care medicine Jul, 2022 | Pubmed ID: 35499759
Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study.
Intensive care medicine Jul, 2022 | Pubmed ID: 35670818
The physiological underpinnings of life-saving respiratory support.
Intensive care medicine Oct, 2022 | Pubmed ID: 35690953
The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing.
Critical care (London, England) Jun, 2022 | Pubmed ID: 35739553
Noninvasive respiratory support in intensive care medicine.
Intensive care medicine Sep, 2022 | Pubmed ID: 35759009
Asymmetrical Lung Injury: Management and Outcome.
Seminars in respiratory and critical care medicine Jun, 2022 | Pubmed ID: 35785812
Correction to: Noninvasive respiratory support in intensive care medicine.
Intensive care medicine Sep, 2022 | Pubmed ID: 35916914
Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy.
EBioMedicine Sep, 2022 | Pubmed ID: 35952495
Do Thresholds for Invasive Ventilation in Hypoxemic Respiratory Failure Exist? A Cohort Study.
American journal of respiratory and critical care medicine Feb, 2023 | Pubmed ID: 36150166
Early Variation of ROX Index Predicts High-Flow Nasal Cannula Outcome in Awake Subjects With Severe Hypoxemic COVID-19.
Respiratory care Jan, 2023 | Pubmed ID: 36167850
Noninvasive Respiratory Support for Adults with Acute Respiratory Failure.
The New England journal of medicine Nov, 2022 | Pubmed ID: 36322846
Mechanical Ventilation in ARDS With an Automatic Resuscitator.
Respiratory care May, 2023 | Pubmed ID: 36368776
Reverse Triggering during Controlled Ventilation: From Physiology to Clinical Management.
American journal of respiratory and critical care medicine Mar, 2023 | Pubmed ID: 36470240
Reply to Wennen : Interpretation of Diaphragmatic Force Measurements in Reverse Triggering in a Porcine Model.
American journal of respiratory and critical care medicine Apr, 2023 | Pubmed ID: 36493770
Possible overestimation of chest wall driving pressure and underestimation of airway closure. Author's reply.
Intensive care medicine Feb, 2023 | Pubmed ID: 36629880
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study.
The Lancet. Respiratory medicine May, 2023 | Pubmed ID: 36693401
Correction: Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study.
Intensive care medicine Mar, 2023 | Pubmed ID: 36729185
Introducing "Viewpoint: Turning the Air Blue".
American journal of respiratory and critical care medicine Apr, 2023 | Pubmed ID: 36753677
Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts.
Critical care (London, England) Feb, 2023 | Pubmed ID: 36814287
Magnitude of Synchronous and Dyssynchronous Inspiratory Efforts during Mechanical Ventilation: A Novel Method.
American journal of respiratory and critical care medicine May, 2023 | Pubmed ID: 36848505
WEAN SAFE and the definition of the first separation attempt - Authors' reply.
The Lancet. Respiratory medicine May, 2023 | Pubmed ID: 36934737
Limiting Dynamic Driving Pressure in Patients Requiring Mechanical Ventilation.
Critical care medicine Jul, 2023 | Pubmed ID: 36971437
Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study.
Trials Mar, 2023 | Pubmed ID: 36973743
Association of lung recruitment and change in recruitment-to-inflation ratio from supine to prone position in acute respiratory distress syndrome.
Critical care (London, England) Apr, 2023 | Pubmed ID: 37055792
First non-invasive magnetic phrenic nerve and diaphragm stimulation in anaesthetized patients: a proof-of-concept study.
Intensive care medicine experimental Apr, 2023 | Pubmed ID: 37081235
Lung Recruitment Assessed by Electrical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine Jul, 2023 | Pubmed ID: 37097986
Physical manoeuvres in patients with ARDS and low compliance: bedside approaches to detect lung hyperinflation and optimise mechanical ventilation.
The European respiratory journal May, 2023 | Pubmed ID: 37208034
Mechanical Ventilation: Negative to Positive and Back Again.
Critical care clinics Jul, 2023 | Pubmed ID: 37230549
Mechanical Ventilation after Traumatic Spinal Cord Injury-A Multicentric Cohort Study-based Prediction Model for Weaning Success: The BICYCLE Score.
Annals of the American Thoracic Society Aug, 2023 | Pubmed ID: 37236632
Tidal lung hysteresis to interpret PEEP-induced changes in compliance in ARDS patients.
Critical care (London, England) Jun, 2023 | Pubmed ID: 37312187
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
Intensive care medicine Jun, 2023 | Pubmed ID: 37326646
Reply to Jimenez and Hyzy and to Le Stang and Dres.
American journal of respiratory and critical care medicine Sep, 2023 | Pubmed ID: 37387595
The Use of the Oxygenation Stretch Index to Predict Outcomes in Mechanically Ventilated Patients With COVID-19 ARDS.
Respiratory care Nov, 2023 | Pubmed ID: 37402585
Bronchodilator Efficacy of High-Flow Nasal Cannula in COPD: Vibrating Mesh Nebulizer Versus Jet Nebulizer.
Respiratory care Jan, 2024 | Pubmed ID: 37607815
Precision Medicine Using Simultaneous Monitoring and Assessment with Imaging and Biomarkers to Manage Mechanical Ventilation in ARDS.
Intensive care research , 2023 | Pubmed ID: 37664686
Sonometric assessment of cough predicts extubation failure: SonoWean-a proof-of-concept study.
Critical care (London, England) Sep, 2023 | Pubmed ID: 37749612
Airway Closure in Patients With Cardiogenic Pulmonary Edema as a Cause of Driving Pressure Overestimation: The "Uncorking Effect".
Chest Nov, 2023 | Pubmed ID: 37945193
High flow nasal catheter therapy versus non-invasive positive pressure ventilation in acute respiratory failure (RENOVATE trial): protocol and statistical analysis plan.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine Mar, 2022 | Pubmed ID: 38046839
A combined frequency domain near infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading.
bioRxiv : the preprint server for biology Dec, 2023 | Pubmed ID: 38076980
Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury.
Intensive care medicine experimental Dec, 2023 | Pubmed ID: 38109016
Pendelluft in hypoxemic patients resuming spontaneous breathing: proportional modes versus pressure support ventilation.
Annals of intensive care Dec, 2023 | Pubmed ID: 38117367
Electrical Impedance Tomography to Monitor Hypoxemic Respiratory Failure.
American journal of respiratory and critical care medicine Mar, 2024 | Pubmed ID: 38127779
The Failure of Extracorporeal Carbon Dioxide Removal May Be a Failure of Technology.
American journal of respiratory and critical care medicine Apr, 2024 | Pubmed ID: 38190699
Noninvasive Ventilation Before Intubation and Mortality in Patients Receiving Extracorporeal Membrane Oxygenation for COVID-19: An Analysis of the Extracorporeal Life Support Organization Registry.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Jul, 2024 | Pubmed ID: 38237635
Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial - A Randomized Clinical Trial.
American journal of respiratory and critical care medicine Mar, 2024 | Pubmed ID: 38261630
Critical Care: A Special Issue of the Blue Journal.
American journal of respiratory and critical care medicine Mar, 2024 | Pubmed ID: 38300147
Ultrasound Evaluation of Parasternal Intercostal, Diaphragm Activity, and Their Ratio in Male Patients with Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine Apr, 2024 | Pubmed ID: 38319129
Limiting Overdistention or Collapse When Mechanically Ventilating Injured Lungs: A Randomized Study in a Porcine Model.
American journal of respiratory and critical care medicine Jun, 2024 | Pubmed ID: 38354065
Noninvasive Electromagnetic Phrenic Nerve Stimulation in Critically Ill Patients: A Feasibility Study.
Chest Sep, 2024 | Pubmed ID: 38403186
Measuring patient's effort on the ventilator.
Intensive care medicine Apr, 2024 | Pubmed ID: 38436722
Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques.
Critical care (London, England) Mar, 2024 | Pubmed ID: 38486268
Critical Care: A Second Special Issue of the Blue Journal.
American journal of respiratory and critical care medicine Apr, 2024 | Pubmed ID: 38501798
Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis.
Intensive care medicine May, 2024 | Pubmed ID: 38512400
Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading.
Journal of biomedical optics Mar, 2024 | Pubmed ID: 38532926
An Individual Barrier Enclosure Actively Removing Aerosols for Airborne Isolation: A Vacuum Tent.
Respiratory care Mar, 2024 | Pubmed ID: 38538026
Reply to Tiruvoipati : VENT-AVOID Trial: Avoiding Acute Hypercapnic Respiratory Failure!
American journal of respiratory and critical care medicine Jun, 2024 | Pubmed ID: 38608271
Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation.
Critical care (London, England) May, 2024 | Pubmed ID: 38730306
Reverse triggering ? a novel or previously missed phenomenon?
Annals of intensive care May, 2024 | Pubmed ID: 38776032
Continuous measurements of respiratory muscle blood flow and oxygen consumption using noninvasive frequency-domain near-infrared spectroscopy and diffuse correlation spectroscopy.
Journal of applied physiology (Bethesda, Md. : 1985) Aug, 2024 | Pubmed ID: 38867669
Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic.
JAMA network open Jul, 2024 | Pubmed ID: 38995645
Prone-position decreases airway closure in a patient with ARDS undergoing venovenous extracorporeal membrane oxygenation.
Journal of clinical monitoring and computing Dec, 2024 | Pubmed ID: 39066871
Reply to Bihari : Alveolar Collapse Is a Threat in Injured Lungs but What About the Airway Opening Pressure.
American journal of respiratory and critical care medicine Aug, 2024 | Pubmed ID: 39133922
Post-insufflation diaphragm contractions in patients receiving various modes of mechanical ventilation.
Critical care (London, England) Sep, 2024 | Pubmed ID: 39294653
Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study.
Annals of intensive care Sep, 2024 | Pubmed ID: 39312044
Heterogeneous impact of Sighs on mortality in patients with acute hypoxemic respiratory failure: insights from the PROTECTION study.
Annals of intensive care Oct, 2024 | Pubmed ID: 39368033
Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion.
Intensive care medicine experimental Oct, 2024 | Pubmed ID: 39432136
Does patient-ventilator asynchrony really matter?
Current opinion in critical care Feb, 2025 | Pubmed ID: 39445589
Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction.
Critical care (London, England) Nov, 2024 | Pubmed ID: 39506755
An International Factorial Vignette-Based Survey of Intubation Decisions in Acute Hypoxemic Respiratory Failure.
Critical care medicine Jan, 2025 | Pubmed ID: 39576153
Fluids Matter in Lung Injury but Not Where We Thought.
American journal of respiratory and critical care medicine Dec, 2024 | Pubmed ID: 39642349
Intermittent Phrenic Nerve Stimulation May Prevent Atelectasis and Ventilator-induced Diaphragm Dysfunction.
American journal of respiratory and critical care medicine Dec, 2024 | Pubmed ID: 39642353
Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial.
Trials Dec, 2024 | Pubmed ID: 39736673
Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study.
Critical care (London, England) Jan, 2025 | Pubmed ID: 39773268
Distribution of airway pressure opening in the lungs measured with electrical impedance tomography (POET): a prospective physiological study.
Critical care (London, England) Jan, 2025 | Pubmed ID: 39819779
Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study.
Annals of intensive care Jan, 2025 | Pubmed ID: 39828725
Antenor Rodrigues1,2,
Luc Janssens3,4,
Daniel Langer4,5,
Umi Matsumura6,
Dmitry Rozenberg7,8,
Laurent Brochard1,2,
W. Darlene Reid2,9,10
1Keenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute, Unity Health Toronto,
2Interdepartmental Division of Critical Care Medicine, University of Toronto,
3Faculty of Engineering Technology, Electrical Engineering, KU Leuven,
4Department of Rehabilitation Sciences, Faculty of Movement and Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, KU Leuven,
5Respiratory Rehabilitation and Respiratory Division, University Hospital Leuven,
6Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences,
7Department of Medicine, Temerty Faculty of Medicine, Division of Respirology, University of Toronto, University Health Network,
8Toronto General Hospital Research Institute, University Health Network,
9Department of Physical Therapy, University of Toronto,
10KITE, Toronto Rehabilitation Institute, University Health Network
ABOUT JoVE
Copyright © 2025 MyJoVE Corporation. All rights reserved