W. Todd Miller

Substrate recognition by the human fatty-acid synthase.

Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.

Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth.

Receptor tyrosine kinases: mechanisms of activation and signaling.

Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region.

Processive phosphorylation: mechanism and biological importance.

Cooperative activation of Src family kinases by SH3 and SH2 ligands.

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation.

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan.

The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition.

A crystallographic snapshot of tyrosine trans-phosphorylation in action.

Evidence for convergent evolution in the signaling properties of a choanoflagellate tyrosine kinase.

Reengineering the signaling properties of a Src family kinase.

Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.

Regulation of Ack1 localization and activity by the amino-terminal SAM domain.

PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis.

Regulation of ack-family nonreceptor tyrosine kinases.

Tyrosine kinase signaling and the emergence of multicellularity.

Effects of somatic mutations in the C-terminus of insulin-like growth factor 1 receptor on activity and signaling.

Lack of Csk-mediated negative regulation in a unicellular SRC kinase.

SRC points the way to biomarkers and chemotherapeutic targets.

Metazoan-like signaling in a unicellular receptor tyrosine kinase.

Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility.

Regulation of Src and Csk nonreceptor tyrosine kinases in the filasterean Ministeria vibrans.

Closing in on a mechanism for activation.

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.

Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.

PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility.

Constitutive Activity in an Ancestral Form of Abl Tyrosine Kinase.

Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids.

Auto-thiophosphorylation activity of Src tyrosine kinase.

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells.

Src signaling in a low-complexity unicellular kinome.

Identification of a Water-Coordinating HER2 Inhibitor by Virtual Screening Using Similarity-Based Scoring.

Src and podoplanin forge a path to destruction.

What Makes a Kinase Promiscuous for Inhibitors?

Sterol structure dependence of insulin receptor and insulin-like growth factor 1 receptor activation.

Substrate binding to Src: A new perspective on tyrosine kinase substrate recognition from NMR and molecular dynamics.

Structure, Function, and Regulation of the SRMS Tyrosine Kinase.

Temperature sensitivities of metazoan and pre-metazoan Src kinases.

Modulation of Src Kinase Activity by Selective Substrate Recognition with Pseudopeptidic Cages.

Phospholipid exchange shows insulin receptor activity is supported by both the propensity to form wide bilayers and ordered raft domains.

Inhibition of mutationally activated HER2.

Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.

The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity.

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance.

Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.

Colorectal cancer-associated mutations impair EphB1 kinase function.

Phosphorylation of Ack1 by the Receptor Tyrosine Kinase Mer.

CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.

Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants.

Contrasting Effects of Cancer-Associated Mutations in EphA3 and EphB2 Kinases.

A microglia clonal inflammatory disorder in Alzheimer's Disease.

ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis.

Effects of heterologous kinase domains on growth factor receptor specificity.

Catalytic activities of wild-type C. elegans DAF-2 kinase and dauer-associated mutants.

Mutations in Mig6 reduce inhibition of the epidermal growth factor receptor.

ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis.

A microglia clonal inflammatory disorder in Alzheimer's disease.