Disease Biophysics Group,
John A. Paulson School of Engineering and Applied Science,
Disease Biophysics Group, John A. Paulson School of Engineering and Applied Science
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Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes.
Biophysical journal Jun, 2007 | Pubmed ID: 17369419
Muscular thin films for building actuators and powering devices.
Science (New York, N.Y.) Sep, 2007 | Pubmed ID: 17823347
Dynamic control of protein-protein interactions.
Langmuir : the ACS journal of surfaces and colloids Jan, 2008 | Pubmed ID: 18052217
Sarcomere alignment is regulated by myocyte shape.
Cell motility and the cytoskeleton Aug, 2008 | Pubmed ID: 18561184
Myofibrillar architecture in engineered cardiac myocytes.
Circulation research Aug, 2008 | Pubmed ID: 18635822
Control of myocyte remodeling in vitro with engineered substrates.
In vitro cellular & developmental biology. Animal , 2009 | Pubmed ID: 19252956
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells.
Science (New York, N.Y.) Oct, 2009 | Pubmed ID: 19833966
Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy.
Circulation. Cardiovascular genetics Apr, 2009 | Pubmed ID: 20031575
Biohybrid thin films for measuring contractility in engineered cardiovascular muscle.
Biomaterials May, 2010 | Pubmed ID: 20149449
Nuclear morphology and deformation in engineered cardiac myocytes and tissues.
Biomaterials Jul, 2010 | Pubmed ID: 20382423
Surface-initiated assembly of protein nanofabrics.
Nano letters Jun, 2010 | Pubmed ID: 20486679
Nanofiber assembly by rotary jet-spinning.
Nano letters Jun, 2010 | Pubmed ID: 20491499
Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.
Experimental biology and medicine (Maywood, N.J.) Mar, 2011 | Pubmed ID: 21330361
Self-organization of muscle cell structure and function.
PLoS computational biology Feb, 2011 | Pubmed ID: 21390276
Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.
Pflugers Archiv : European journal of physiology Jul, 2011 | Pubmed ID: 21499986
A possible role for integrin signaling in diffuse axonal injury.
PloS one , 2011 | Pubmed ID: 21799943
Vascular smooth muscle contractility depends on cell shape.
Integrative biology : quantitative biosciences from nano to macro Nov, 2011 | Pubmed ID: 21993765
Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip.
Lab on a chip Dec, 2011 | Pubmed ID: 22072288
Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22123981
Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior.
Journal of biomechanics Mar, 2012 | Pubmed ID: 22236531
Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current.
Cardiovascular research Apr, 2012 | Pubmed ID: 22287588
Muscle on a chip: in vitro contractility assays for smooth and striated muscle.
Journal of pharmacological and toxicological methods , 2012 | Pubmed ID: 22521339
Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture.
Biomaterials Aug, 2012 | Pubmed ID: 22594976
Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2012 | Pubmed ID: 22675119
The contribution of cellular mechanotransduction to cardiomyocyte form and function.
Biomechanics and modeling in mechanobiology Nov, 2012 | Pubmed ID: 22772714
A potential role for integrin signaling in mechanoelectrical feedback.
Progress in biophysics and molecular biology , 2012 | Pubmed ID: 22819851
A tissue-engineered jellyfish with biomimetic propulsion.
Nature biotechnology Aug, 2012 | Pubmed ID: 22820316
Design standards for engineered tissues.
Biotechnology advances , 2013 | Pubmed ID: 23267860
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2013 | Pubmed ID: 23716679
Microfluidic heart on a chip for higher throughput pharmacological studies.
Lab on a chip Sep, 2013 | Pubmed ID: 23807141
Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes.
Stem cell reports , 2013 | Pubmed ID: 24286027
The contractile strength of vascular smooth muscle myocytes is shape dependent.
Integrative biology : quantitative biosciences from nano to macro Feb, 2014 | Pubmed ID: 24406783
Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning.
Biomaterials Mar, 2014 | Pubmed ID: 24456606
The structure-function relationships of a natural nanoscale photonic device in cuttlefish chromatophores.
Journal of the Royal Society, Interface Apr, 2014 | Pubmed ID: 24478280
Three-dimensional paper-based model for cardiac ischemia.
Advanced healthcare materials Jul, 2014 | Pubmed ID: 24574054
Quality metrics for stem cell-derived cardiac myocytes.
Stem cell reports Mar, 2014 | Pubmed ID: 24672752
Matrix elasticity regulates the optimal cardiac myocyte shape for contractility.
American journal of physiology. Heart and circulatory physiology Jun, 2014 | Pubmed ID: 24682394
Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues.
Biomaterials Jul, 2014 | Pubmed ID: 24731714
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.
Nature medicine Jun, 2014 | Pubmed ID: 24813252
Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation.
Lab on a chip Oct, 2014 | Pubmed ID: 25093641
The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function.
Anatomical record (Hoboken, N.J. : 2007) Sep, 2014 | Pubmed ID: 25125187
Effect of solvent evaporation on fiber morphology in rotary jet spinning.
Langmuir : the ACS journal of surfaces and colloids Nov, 2014 | Pubmed ID: 25353398
Structural phenotyping of stem cell-derived cardiomyocytes.
Stem cell reports Mar, 2015 | Pubmed ID: 25733020
Traumatic brain injury and the neuronal microenvironment: a potential role for neuropathological mechanotransduction.
Neuron Mar, 2015 | Pubmed ID: 25789754
Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury.
Scientific reports Mar, 2015 | Pubmed ID: 25820512
Metrics for assessing cytoskeletal orientational correlations and consistency.
PLoS computational biology Apr, 2015 | Pubmed ID: 25849553
Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes.
Experimental biology and medicine (Maywood, N.J.) Apr, 2015 | Pubmed ID: 25908635
Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip.
Advanced functional materials Aug, 2013 | Pubmed ID: 26213529
Extracellular matrix protein expression is brain region dependent.
The Journal of comparative neurology May, 2016 | Pubmed ID: 26780384
Angiotensin II Induced Cardiac Dysfunction on a Chip.
PloS one , 2016 | Pubmed ID: 26808388
Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.
The Journal of cell biology Feb, 2016 | Pubmed ID: 26858266
Acute pergolide exposure stiffens engineered valve interstitial cell tissues and reduces contractility in vitro.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology , 2016 | Pubmed ID: 27174867
Microenvironmental Control of Adipocyte Fate and Function.
Trends in cell biology Oct, 2016 | Pubmed ID: 27268909
Phototactic guidance of a tissue-engineered soft-robotic ray.
Science (New York, N.Y.) Jul, 2016 | Pubmed ID: 27387948
A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility.
The Journal of cell biology Oct, 2016 | Pubmed ID: 27697929
Organ Chips: Quality Assurance Systems in Regenerative Medicine.
Clinical pharmacology and therapeutics Jan, 2017 | Pubmed ID: 27709615
Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip.
Journal of neurophysiology Mar, 2017 | Pubmed ID: 28031399
Mechanotransduction and Metabolism in Cardiomyocyte Microdomains.
BioMed research international , 2016 | Pubmed ID: 28044126
Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarction model.
Biomaterials Apr, 2017 | Pubmed ID: 28107664
JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement.
Biomaterials Jul, 2017 | Pubmed ID: 28445803
Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities.
Lab on a chip 06, 2017 | Pubmed ID: 28608907
Fabrication of Millimeter-Long Carbon Tubular Nanostructures Using the Self-Rolling Process Inherent in Elastic Protein Layers.
Advanced materials (Deerfield Beach, Fla.) Aug, 2017 | Pubmed ID: 28627043
Comparative analysis of poly-glycolic acid-based hybrid polymer starter matrices for in vitro tissue engineering.
Colloids and surfaces. B, Biointerfaces Oct, 2017 | Pubmed ID: 28697435
Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions.
Journal of biomechanical engineering Dec, 2017 | Pubmed ID: 28857113
Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications.
Biofabrication Jan, 2018 | Pubmed ID: 29337695
Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing.
Advanced healthcare materials May, 2018 | Pubmed ID: 29359866
Formation of Multi-Component Extracellular Matrix Protein Fibers.
Scientific reports Jan, 2018 | Pubmed ID: 29382927
Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model.
Biomaterials Jun, 2018 | Pubmed ID: 29549768
Traction force microscopy of engineered cardiac tissues.
PloS one , 2018 | Pubmed ID: 29590169
Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials.
Analytical and bioanalytical chemistry Sep, 2018 | Pubmed ID: 29744562
Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system.
Nature biotechnology Jul, 2018 | Pubmed ID: 29806849
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.
Nature biotechnology Oct, 2018 | Pubmed ID: 30125269
Scatter Enhanced Phase Contrast Microscopy for Discriminating Mechanisms of Active Nanoparticle Transport in Living Cells.
Nano letters Feb, 2019 | Pubmed ID: 30616354
Designer Assays for Your Sick, Subdivided Heart.
Cell Feb, 2019 | Pubmed ID: 30735631
A tissue-engineered scale model of the heart ventricle.
Nature biomedical engineering Dec, 2018 | Pubmed ID: 31015723
Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue.
Circulation 07, 2019 | Pubmed ID: 31311300
Alfalfa Nanofibers for Dermal Wound Healing.
ACS applied materials & interfaces Sep, 2019 | Pubmed ID: 31369233
Inkjet-Printed Carbon Nanotubes for Fabricating a Spoof Fingerprint on Paper.
ACS omega May, 2019 | Pubmed ID: 31459951
Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing.
Lab on a chip Sep, 2019 | Pubmed ID: 31464325
Quantifying the effects of engineered nanomaterials on endothelial cell architecture and vascular barrier integrity using a cell pair model.
Nanoscale Oct, 2019 | Pubmed ID: 31553035
Muscle tissue engineering in fibrous gelatin: implications for meat analogs.
NPJ science of food , 2019 | Pubmed ID: 31646181
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.
Circulation Jan, 2020 | Pubmed ID: 31707831
Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair.
ACS applied materials & interfaces Dec, 2019 | Pubmed ID: 31755704
Human brain microvascular endothelial cell pairs model tissue-level blood-brain barrier function.
Integrative biology : quantitative biosciences from nano to macro Apr, 2020 | Pubmed ID: 32195539
Laminar ventricular myocardium on a microelectrode array-based chip.
Journal of materials chemistry. B May, 2016 | Pubmed ID: 32263387
Biomimetic and estrogenic fibers promote tissue repair in mice and human skin via estrogen receptor β.
Biomaterials Oct, 2020 | Pubmed ID: 32521331
Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction.
ACS biomaterials science & engineering Jul, 2020 | Pubmed ID: 32685675
Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine.
Advanced biosystems Sep, 2020 | Pubmed ID: 32744807
A bioinspired and hierarchically structured shape-memory material.
Nature materials Feb, 2021 | Pubmed ID: 32868876
Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes .
Lab on a chip Nov, 2020 | Pubmed ID: 33034335
Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip.
Science translational medicine Oct, 2020 | Pubmed ID: 33055246
Ultragentle manipulation of delicate structures using a soft robotic gripper.
Science robotics Aug, 2019 | Pubmed ID: 33137785
Mapping 2D- and 3D-distributions of metal/metal oxide nanoparticles within cleared human skin tissues.
NanoImpact Jan, 2020 | Pubmed ID: 33251378
Building Biomimetic Potency Tests for Islet Transplantation.
Diabetes Feb, 2021 | Pubmed ID: 33472944
Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2021 | Pubmed ID: 34260377
An autonomously swimming biohybrid fish designed with human cardiac biophysics.
Science (New York, N.Y.) Feb, 2022 | Pubmed ID: 35143298
Addendum: A tissue-engineered scale model of the heart ventricle.
Nature biomedical engineering Nov, 2022 | Pubmed ID: 35260798
Differential modulation of endothelial cytoplasmic protrusions after exposure to graphene-family nanomaterials.
NanoImpact Apr, 2022 | Pubmed ID: 35560286
Cellular and Engineered Organoids for Cardiovascular Models.
Circulation research Jun, 2022 | Pubmed ID: 35679369
Recreating the heart's helical structure-function relationship with focused rotary jet spinning.
Science (New York, N.Y.) Jul, 2022 | Pubmed ID: 35857545
Engineering multicellular living systems-a Keystone Symposia report.
Annals of the New York Academy of Sciences Dec, 2022 | Pubmed ID: 36177947
Biohybrid robots: recent progress, challenges, and perspectives.
Bioinspiration & biomimetics Nov, 2022 | Pubmed ID: 36265472
High-throughput coating with biodegradable antimicrobial pullulan fibres extends shelf life and reduces weight loss in an avocado model.
Nature food Jun, 2022 | Pubmed ID: 37118042
Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles.
Nature materials Aug, 2023 | Pubmed ID: 37500957
Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy.
Stem cell reports Sep, 2023 | Pubmed ID: 37595583
Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy.
Journal of molecular and cellular cardiology Jan, 2024 | Pubmed ID: 37956903
Self-organizing behaviors of cardiovascular cells on synthetic nanofiber scaffolds.
APL bioengineering Dec, 2023 | Pubmed ID: 38046543
Welcome to , a big tent for the biophysics community.
Biophysics reviews Dec, 2020 | Pubmed ID: 38505630
Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems.
Nature communications Jul, 2024 | Pubmed ID: 39009604
Bioinspired design of a tissue-engineered ray with machine learning.
Science robotics Feb, 2025 | Pubmed ID: 39937888
Chiara Florindi*,1,2,3,
Yongjun Jang*,3,
Kevin Shani3,
Paola Moretti2,4,
Chiara Bertarelli2,4,
Guglielmo Lanzani2,5,
Kevin Kit Parker3,
Francesco Lodola1,2,
Vito Vurro2,3,6
1Department of Biotechnology and Biosciences, University of Milano-Bicocca,
2Center for Nano Science and Technology, Istituto Italiano di Tecnologia,
3Disease Biophysics Group, John A. Paulson School of Engineering and Applied Science, Harvard University,
4Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano,
5Department of Physics, Politecnico di Milano,
6Department of Physics and Astronomy, University of Bologna
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