Olga Yurieva

Analysis of a multicomponent thermostable DNA polymerase III replicase from an extreme thermophile.

Structure of a sliding clamp on DNA.

Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.

Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase.

Mechanism of polymerase collision release from sliding clamps on the lagging strand.

Cost of rNTP/dNTP pool imbalance at the replication fork.

Replisome mechanics: lagging strand events that influence speed and processivity.

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.

CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation.

Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases.

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks.

Insights into RNA polymerase catalysis and adaptive evolution gained from mutational analysis of a locus conferring rifampicin resistance.

Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication.

Replisome bypass of a protein-based R-loop block by Pif1.

CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism.

Nucleosome-directed replication origin licensing independent of a consensus DNA sequence.

Origin recognition complex harbors an intrinsic nucleosome remodeling activity.

Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis.