Stephen R. Quake

Howard Hughes Medical Institute

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PUBLICATIONS

Genome research Jan, 2002 | Pubmed ID: 11779839

An integrated microfabricated cell sorter.

Analytical chemistry Jun, 2002 | Pubmed ID: 12069222

Electrophoresis Aug, 2002 | Pubmed ID: 12210169

Proceedings of the National Academy of Sciences of the United States of America Oct, 2002 | Pubmed ID: 12235357

Science (New York, N.Y.) Oct, 2002 | Pubmed ID: 12351675

Identification and confirmation of a module of coexpressed genes.

Genome research Oct, 2002 | Pubmed ID: 12368243

Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions.

The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2002 | Pubmed ID: 12451126

A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion.

Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12486223

Biophysical journal Feb, 2003 | Pubmed ID: 12547808

Sequence information can be obtained from single DNA molecules.

Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12651960

BioTechniques Mar, 2003 | Pubmed ID: 12661156

Microfluidic memory and control devices.

Science (New York, N.Y.) May, 2003 | Pubmed ID: 12738857

Genome research Oct, 2003 | Pubmed ID: 12975313

Nature biotechnology Oct, 2003 | Pubmed ID: 14520403

Current opinion in structural biology Oct, 2003 | Pubmed ID: 14568607

Analytical chemistry Sep, 2003 | Pubmed ID: 14674446

Physical review letters Dec, 2003 | Pubmed ID: 14754067

Journal of the American Chemical Society Mar, 2004 | Pubmed ID: 14982433

Nature biotechnology Apr, 2004 | Pubmed ID: 15024389

A microfluidic rectifier: anisotropic flow resistance at low Reynolds numbers.

Physical review letters Mar, 2004 | Pubmed ID: 15089471

Nucleic acids research , 2004 | Pubmed ID: 15155856

Proceedings of the National Academy of Sciences of the United States of America Oct, 2004 | Pubmed ID: 15452343

Physical review letters Oct, 2004 | Pubmed ID: 15525147

Long-term monitoring of bacteria undergoing programmed population control in a microchemostat.

Science (New York, N.Y.) Jul, 2005 | Pubmed ID: 15994559

Chemical communications (Cambridge, England) Sep, 2005 | Pubmed ID: 16158111

Science (New York, N.Y.) Dec, 2005 | Pubmed ID: 16357255

Nucleosides, nucleotides & nucleic acids , 2006 | Pubmed ID: 16440981

Analytical chemistry Feb, 2006 | Pubmed ID: 16448074

BioTechniques Jan, 2006 | Pubmed ID: 16454045

Journal of the American Chemical Society Mar, 2006 | Pubmed ID: 16522084

Physical review letters Mar, 2006 | Pubmed ID: 16606228

Analytical chemistry May, 2006 | Pubmed ID: 16642997

Nature Jul, 2006 | Pubmed ID: 16871205

Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17075056

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR.

Proceedings of the National Academy of Sciences of the United States of America Nov, 2006 | Pubmed ID: 17098862

Microfluidic digital PCR enables multigene analysis of individual environmental bacteria.

Science (New York, N.Y.) Dec, 2006 | Pubmed ID: 17138901

Lab on a chip Jan, 2007 | Pubmed ID: 17180201

Science (New York, N.Y.) Jan, 2007 | Pubmed ID: 17218526

Annual review of biophysics and biomolecular structure , 2007 | Pubmed ID: 17269901

Physical review letters Dec, 2006 | Pubmed ID: 17280412

Biochemistry May, 2007 | Pubmed ID: 17441732

Proceedings of the National Academy of Sciences of the United States of America Jul, 2007 | Pubmed ID: 17620602

Analytical chemistry Oct, 2007 | Pubmed ID: 17715994

Nanoliter reactors improve multiple displacement amplification of genomes from single cells.

PLoS genetics Sep, 2007 | Pubmed ID: 17892324

Transcriptional instability is not a universal attribute of aging.

Aging cell Dec, 2007 | Pubmed ID: 17925006

Versatile, fully automated, microfluidic cell culture system.

Analytical chemistry Nov, 2007 | Pubmed ID: 17953452

Lab on a chip Jan, 2008 | Pubmed ID: 18094763

Single-molecule DNA sequencing of a viral genome.

Science (New York, N.Y.) Apr, 2008 | Pubmed ID: 18388294

A synthetic Escherichia coli predator-prey ecosystem.

Molecular systems biology , 2008 | Pubmed ID: 18414488

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

Nature biotechnology Sep, 2008 | Pubmed ID: 18758449

Proceedings of the National Academy of Sciences of the United States of America Oct, 2008 | Pubmed ID: 18838674

An in vitro microfluidic approach to generating protein-interaction networks.

Nature methods Jan, 2009 | Pubmed ID: 19098921

Association of reactive oxygen species levels and radioresistance in cancer stem cells.

Nature Apr, 2009 | Pubmed ID: 19194462

Digital PCR provides sensitive and absolute calibration for high throughput sequencing.

BMC genomics , 2009 | Pubmed ID: 19298667

Developmental dynamics : an official publication of the American Association of Anatomists Apr, 2009 | Pubmed ID: 19301395

American journal of obstetrics and gynecology May, 2009 | Pubmed ID: 19375573

Journal of applied physics , 2007 | Pubmed ID: 19381353

Automated microfluidic chromatin immunoprecipitation from 2,000 cells.

Lab on a chip May, 2009 | Pubmed ID: 19417902

High-throughput sequencing of the zebrafish antibody repertoire.

Science (New York, N.Y.) May, 2009 | Pubmed ID: 19423829

Nature biotechnology Sep, 2009 | Pubmed ID: 19668243

Applied physics letters Aug, 2009 | Pubmed ID: 19777091

Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19841254

Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 19906998

Nature nanotechnology Feb, 2010 | Pubmed ID: 20023643

Nucleic acids research May, 2010 | Pubmed ID: 20176572

Lancet May, 2010 | Pubmed ID: 20435227

PloS one , 2010 | Pubmed ID: 20454671

Physical review letters Apr, 2010 | Pubmed ID: 20482145

Clinical chemistry Aug, 2010 | Pubmed ID: 20558635

Nature Jul, 2010 | Pubmed ID: 20581820

De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis.

Nature biotechnology Sep, 2010 | Pubmed ID: 20802496

Analytical chemistry Oct, 2010 | Pubmed ID: 20936785

Biophysical journal Oct, 2010 | Pubmed ID: 20959081

Digital MDA for enumeration of total nucleic acid contamination.

Nucleic acids research Mar, 2011 | Pubmed ID: 21071419

Nature biotechnology Jan, 2011 | Pubmed ID: 21170043

Nature methods Mar, 2011 | Pubmed ID: 21297618

Genome of a low-salinity ammonia-oxidizing archaeon determined by single-cell and metagenomic analysis.

PloS one , 2011 | Pubmed ID: 21364937

Nature medicine Mar, 2011 | Pubmed ID: 21383717

Determinism and stochasticity during maturation of the zebrafish antibody repertoire.

Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21393572

Proceedings of the National Academy of Sciences of the United States of America Apr, 2011 | Pubmed ID: 21444804

Nature methods Apr, 2011 | Pubmed ID: 21451520

An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells.

PloS one , 2011 | Pubmed ID: 21731674

Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.

PLoS genetics Jun, 2011 | Pubmed ID: 21738489

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.

Nature biotechnology Aug, 2011 | Pubmed ID: 21804562

Partial genome assembly for a candidate division OP11 single cell from an anoxic spring (Zodletone Spring, Oklahoma).

Applied and environmental microbiology Nov, 2011 | Pubmed ID: 21908640

Genomic analysis at the single-cell level.

Annual review of genetics , 2011 | Pubmed ID: 21942365

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding.

Nature biotechnology Oct, 2011 | Pubmed ID: 21964413

Digital PCR provides absolute quantitation of viral load for an occult RNA virus.

Journal of virological methods Jan, 2012 | Pubmed ID: 21983150

Single-cell dissection of transcriptional heterogeneity in human colon tumors.

Nature biotechnology Dec, 2011 | Pubmed ID: 22081019

The Plant cell Dec, 2011 | Pubmed ID: 22186371

Identification of a Ckit+ Colonic Crypt Base Secretory Cell that Supports Lgr5+ Stem Cells in Mice.

Gastroenterology Feb, 2012 | Pubmed ID: 22333952

Circulation Feb, 2012 | Pubmed ID: 22354974

Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).

Genome research Jun, 2012 | Pubmed ID: 22434425

Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns.

Nature protocols May, 2012 | Pubmed ID: 22481529

Lab on a chip Jun, 2012 | Pubmed ID: 22566096

Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines.

PloS one , 2012 | Pubmed ID: 22586443

Lab on a chip Jun, 2012 | Pubmed ID: 22714259

Nature Jul, 2012 | Pubmed ID: 22763444

INSTITUTIONS

Howard Hughes Medical Institute

Stanford University

JOVE ARTICLES

Time-lapse Fluorescence Imaging of Arabidopsis Root Growth with Rapid Manipulation of The Root Environment Using The RootChip

Guido Grossmann¹,

Matthias Meier^2,3,4,

Heather N. Cartwright¹,

Davide Sosso¹,

Stephen R. Quake^2,3,

David W. Ehrhardt¹,

Wolf B. Frommer¹

¹Department of Plant Biology, Carnegie Institution for Science,

², Howard Hughes Medical Institute,

³Departments of Applied Physics and Bioengineering, Stanford University ,

⁴Department of Microsystems Engineering (IMTEK) and Center for Biological Signaling Studies (BIOSS), University of Freiburg

Bioengineering

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