Adam J. Adler

Arthritis and Clinical Immunology, oklahoma medical research foundation

Affiliated withoklahoma medical research foundation

Research Area

BiologyUnit 2

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2013

Other Publications

Article	Year
CD4 cell priming and tolerization are differentially programmed by APCs upon initial engagement. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12023353	2002
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12244153	2002
CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12682221	2003
Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-alpha and IFN-gamma expression potentials. Cellular immunology\| PubMed ID: 14609577	2003
In vivo cyclophosphamide and IL-2 treatment impedes self-antigen-induced effector CD4 cell tolerization: implications for adoptive immunotherapy. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15100273	2004
Glycoprotein 96 can chaperone both MHC class I- and class II-restricted epitopes for in vivo presentation, but selectively primes CD8+ T cell effector function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15128793	2004
Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer cell\| PubMed ID: 15766662	2005
T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16393991	2006
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 16868974	2006
Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16982857	2006
Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis. The Prostate\| PubMed ID: 17221844	2007
Mechanisms of T cell tolerance and suppression in cancer mediated by tumor-associated antigens and hormones. Current cancer drug targets\| PubMed ID: 17305474	2007
Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17641018	2007
Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17947638	2007
The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death. Journal of leukocyte biology\| PubMed ID: 18923104	2009
Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19017962	2008
In vitro and in vivo differentiated effector CD8 T cells display divergent histone acetylation patterns within the Ifng locus. Immunology letters\| PubMed ID: 19195486	2009
The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19801520	2009
Blood feeding by the Rocky Mountain spotted fever vector, Dermacentor andersoni, induces interleukin-4 expression by cognate antigen responding CD4+ T cells. Parasites & vectors\| PubMed ID: 19814808	2009
Tc17 CD8 T cells: functional plasticity and subset diversity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19917680	2009
Peripheral Tolerization of Effector and Memory T Cells: Implications for Autoimmunity and Tumor-Immunity. Current immunology reviews\| PubMed ID: 20411047	2005
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21880986	2011
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. American journal of human genetics\| PubMed ID: 22464253	2012
Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22689946	2012
Two independent functional risk haplotypes in TNIP1 are associated with systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 22833143	2012
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood\| PubMed ID: 22993390	2012
CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion. Immunology and cell biology\| PubMed ID: 23295363	2013
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation. Oncoimmunology\| PubMed ID: 23482891	2013
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nature genetics\| PubMed ID: 24097067	2013