Adelino Leite-Moreira

Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.

Current perspectives in diastolic dysfunction and diastolic heart failure.

Physiologic basis and pathophysiologic implications of the diastolic properties of the cardiac muscle.

Intraventricular pressure gradients throughout the cardiac cycle: effects of ischaemia and modulation by afterload.

Comparison of different methods of heart rate entropy analysis during acute anoxia superimposed on a chronic rat model of pulmonary hypertension.

Blunted renal dopaminergic system in a mouse model of diet-induced obesity.

Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans.

Helicobacter pylori induces increased expression of Toll-like receptors and decreased Toll-interacting protein in gastric mucosa that persists throughout gastric carcinogenesis.

Cardiac magnetic resonance myocardial perfusion imaging for detection of functionally significant obstructive coronary artery disease: a prospective study.

Reverse myocardial effects of intermedin in pressure-overloaded hearts: role of endothelial nitric oxide synthase activity.

Cardiac venous arterialization in acute myocardial infarction: how great is the benefit?

Therapeutic potential of neuregulin-1 in cardiovascular disease.

The effects of angiotensin II signaling pathway in the systolic response to acute stretch in the normal and ischemic myocardium.

Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk.

Pivotal role of microRNAs in cardiac physiology and heart failure.

CAD detection in patients with intermediate-high pre-test probability: low-dose CT delayed enhancement detects ischemic myocardial scar with moderate accuracy but does not improve performance of a stress-rest CT perfusion protocol.

Adiponectin levels are elevated in patients with pulmonary arterial hypertension.

Load independent impairment of reverse remodeling after valve replacement in hypertensive aortic stenosis patients.

METformin in DIastolic Dysfunction of MEtabolic syndrome (MET-DIME) trial: rationale and study design : MET-DIME trial.

Central nervous system circuits modified in heart failure: pathophysiology and therapeutic implications.

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.

Expert position paper on the management of antiplatelet therapy in patients undergoing coronary artery bypass graft surgery.

Myocardial and anti-inflammatory effects of chronic bosentan therapy in monocrotaline-induced pulmonary hypertension.

Preinfarction angina: clinical significance and relationship with total ischemic time in patients with ST-elevation myocardial infarction.

S100A1: a major player in cardiovascular performance.

Revisiting the slow force response: the role of the PKG signaling pathway in the normal and the ischemic heart.

Determinants of clinical improvement after surgical replacement or transcatheter aortic valve implantation for isolated aortic stenosis.

Angiotensin-(1-7) modulates angiotensin II-induced vasoconstriction in human mammary artery.

Influence of epicardial and visceral fat on left ventricular diastolic and systolic functions in patients after myocardial infarction.

Concomitant unipolar radiofrequency ablation of nonparoxysmal atrial fibrillation in rheumatic and degenerative valve disease.

Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes.

Pathophysiology of infantile pulmonary arterial hypertension induced by monocrotaline.

Left ventricular diastolic dysfunction and E/E' ratio as the strongest echocardiographic predictors of reduced exercise capacity after acute myocardial infarction.

Urocortin 2 in cardiovascular health and disease.

Association between plasma leptin and adiponectin levels and diastolic function in the general population.

Lack of Benefit of Ischemic Postconditioning After Routine Thrombus Aspiration During Reperfusion: Immediate and Midterm Results.

Echocardiography and invasive hemodynamics during stress testing for diagnosis of heart failure with preserved ejection fraction: an experimental study.

The role of a structured exercise training program on cardiac structure and function after acute myocardial infarction: study protocol for a randomized controlled trial.

Direct, inflammation-mediated and blood-pressure-mediated effects of total and abdominal adiposity on diastolic function: EPIPorto study.

Recommendations on pre-hospital and early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine--short version.

Recommendations on pre-hospital & early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine.

Atherosclerosis: Recent trials, new targets and future directions.

Intermittent cardiac overload results in adaptive hypertrophy and provides protection against left ventricular acute pressure overload insult.

Titin mutations: the fall of Goliath.

Relevance of residual left ventricular hypertrophy after surgery for isolated aortic stenosis.

Clinical value of natriuretic peptides in chronic kidney disease.

Remote ischemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI): study protocol for a randomized controlled trial.

The Effect of Exercise Training on Diastolic and Systolic Function After Acute Myocardial Infarction: A Randomized Study.

Afterload-induced diastolic dysfunction contributes to high filling pressures in experimental heart failure with preserved ejection fraction.

Signaling pathways underlying skeletal muscle wasting in experimental pulmonary arterial hypertension.

Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension.

Spectral transfer function analysis of respiratory hemodynamic fluctuations predicts end-diastolic stiffness in preserved ejection fraction heart failure.

Neuregulin-1 improves right ventricular function and attenuates experimental pulmonary arterial hypertension.

Role of colonic microbiota in colorectal carcinogenesis: a systematic review.

Exercise preconditioning prevents MCT-induced right ventricle remodeling through the regulation of TNF superfamily cytokines.

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction.

On the study of the role of NO-mediated pathways in the myocardial response to acute stretch.

Acute Myocardial Response to Stretch: What We (don't) Know.

CT myocardial perfusion and coronary CT angiography: Influence of coronary calcium on a stress-rest protocol.

Distinct Endothelial Cell Responses in the Heart and Kidney Microvasculature Characterize the Progression of Heart Failure With Preserved Ejection Fraction in the Obese ZSF1 Rat With Cardiorenal Metabolic Syndrome.

Time-dependence of cardiac biomarker levels in newborns with congenital heart defects: Umbilical cord versus peripheral newborn blood.

Myocardial Injury Biomarkers in Newborns with Congenital Heart Disease.

Soluble TNF-related apoptosis induced ligand (sTRAIL) is augmented by Post-Conditioning and correlates to infarct size and left ventricle dysfunction in STEMI patients: a substudy from a randomized clinical trial.

Cardiac injury biomarkers in paediatric age: Are we there yet?

Right ventricular end-diastolic stiffness heralds right ventricular failure in monocrotaline-induced pulmonary hypertension.

Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.

Pulmonary arterial hypertension: Basic knowledge for clinicians.

The Utility of Brain Natriuretic Peptide in Pediatric Cardiology: A Review.

Can Adiponectin Help us to Target Diastolic Dysfunction?

The Ratio Between Visceral and Subcutaneous Abdominal Fat Assessed by Computed Tomography Is an Independent Predictor of Mortality and Cardiac Events.

Biomarkers of aortic valve stenosis: Should we rely on a single one?

Towards the standardization of stem cell therapy studies for ischemic heart diseases: Bridging the gap between animal models and the clinical setting.

Methodological approaches and insights on protein aggregation in biological systems.

Manual thrombectomy efficiency in relationship to the area at risk in patients with myocardial infarction with TIMI 0-1 coronary flow: Insights from an all comers registry.

Improvement in left intraventricular pressure gradients after aortic valve replacement in aortic stenosis patients.

Characterization of liver changes in ZSF1 rats, an animal model of metabolic syndrome.

Dose-Response Head-to-Head Comparison of Inodilators Dobutamine, Milrinone, and Levosimendan in Chronic Experimental Pulmonary Hypertension.

Ventricular-arterial coupling in heart failure with preserved ejection fraction: the devil is in the details.

Systematic Review of the Relation Between Intestinal Microbiota and Toll-Like Receptors in the Metabolic Syndrome: What Do We Know So Far?

Gender differences in the association of epicardial adipose tissue and coronary artery calcification: EPICHEART study: EAT and coronary calcification by gender.

Exercise Training in Pulmonary Hypertension and Right Heart Failure: Insights from Pre-clinical Studies.

Association of body mass index and visceral fat with aortic valve calcification and mortality after transcatheter aortic valve replacement: the obesity paradox in severe aortic stenosis.

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.

Epicardial adipose tissue volume assessed by computed tomography and coronary artery disease: a systematic review and meta-analysis.

Impact of the 2016 ASE/EACVI recommendations on the prevalence of diastolic dysfunction in the general population.

Chronic exercise induces pathological left ventricular hypertrophy in adrenaline-deficient mice.

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.

Freedom Solo® versus Trifecta® bioprostheses: clinical and haemodynamic evaluation after propensity score matching.

Stretch-induced compliance: a novel adaptive biological mechanism following acute cardiac load.

EndoProteoFASP as a Tool to Unveil the Peptidome-Protease Profile: Application to Salivary Diagnostics.

Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI).

Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension.

Reply to Ngu et al.

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock.

Survival after bilateral internal mammary artery in coronary artery bypass grafting: Are women at risk?

Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity.

Collagen biomarker bioprofiles predicting the antifibrotic response to eplerenone in myocardial infarction: findings from the REMINDER trial.

Left atrial deformation analysis by speckle tracking echocardiography to predict exercise capacity after myocardial infarction.

Hemodynamic and clinical performance of Solo stentless bioprosthetic aortic valves.

Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental pulmonary hypertension.

Meta-Analysis of Relation of Epicardial Adipose Tissue Volume to Left Atrial Dilation and to Left Ventricular Hypertrophy and Functions.

The impact of preinfarct angina on the incidence of acute kidney injury in patients with myocardial infarction: interaction with pre-existent chronic kidney disease.

Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload.

The Role of Thyroid Hormones in Heart Failure.

Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.

Lower free triiodothyronine levels within the reference range are associated with higher cardiovascular mortality: An analysis of the NHANES.

The impact of thyroid hormone dysfunction on ischemic heart disease.

Myocardial Edema: an Overlooked Mechanism of Septic Cardiomyopathy?

Cardiovascular Effects of Urocortin-2: Pathophysiological Mechanisms and Therapeutic Potential.

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction.

Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction.

Malassezia colonisation on a reconstructed human epidermis: Imaging studies.

The cholesterol paradox may be attenuated in heart failure patients with diabetes.

Relaxin and the Cardiovascular System: from Basic Science to Clinical Practice.

Epicardial adipose tissue volume and annexin A2/fetuin-A signalling are linked to coronary calcification in advanced coronary artery disease: Computed tomography and proteomic biomarkers from the EPICHEART study.

Nationwide Analysis of Intact Abdominal Aortic Aneurysm Repair in Portugal from 2000 to 2015.

The impact of diastolic dysfunction as a predictor of cardiovascular events: A systematic review and meta-analysis.

Risk Factors for Recoarctation and Mortality in Infants Submitted to Aortic Coarctation Repair: A Systematic Review.

EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases.

Dual antiplatelet therapy after coronary artery bypass grafting: A safe option after all? Comment on a published meta-analysis.

Cardiovascular precision medicine: Bad news from the front?

Nationwide Analysis of Ruptured Abdominal Aortic Aneurysm in Portugal (2000-2015).

Fat Quality Matters: Distinct Proteomic Signatures Between Lean and Obese Cardiac Visceral Adipose Tissue Underlie its Differential Myocardial Impact.

Gender Differences in Predictors and Long-Term Mortality of New-Onset Postoperative Atrial Fibrillation Following Isolated Aortic Valve Replacement Surgery.

Early dual antiplatelet therapy versus aspirin monotherapy after coronary artery bypass surgery: survival and safety outcomes.

MicroRNAs and ventricular remodeling in aortic stenosis.

Multiple versus single arterial grafting in coronary artery bypass grafting: A meta-analysis of randomized controlled trials and propensity score studies.

Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches.

Preoperative myocardial expression of E3 ubiquitin ligases in aortic stenosis patients undergoing valve replacement and their association to postoperative hypertrophy.

Mobile cardiology during the COVID-19 outbreak.

The tight tie of MAG versus SAG in CABG.

Increased Transglutaminase 2 Expression and Activity in Rodent Models of Obesity/Metabolic Syndrome and Aging.

Early And Midterm Outcomes Following Aortic Valve Replacement With Mechanical Versus Bioprosthetic Valves In Patients Aged 50 To 70 Years.

Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Protocol for a translational study in coronary atherosclerosis.

Unraveling the Role of Epicardial Adipose Tissue in Coronary Artery Disease: Partners in Crime?

Exploratory analysis of large-scale lipidome in large cohorts: are we any closer of finding lipid-based markers suitable for CVD risk stratification and management?

The Degree of Cardiac Remodelling before Overload Relief Triggers Different Transcriptome and miRome Signatures during Reverse Remodelling (RR)-Molecular Signature Differ with the Extent of RR.

Mechanisms underlying the pathophysiology of heart failure with preserved ejection fraction: the tip of the iceberg.

Exosome-Derived Mediators as Potential Biomarkers for Cardiovascular Diseases: A Network Approach.

Nicotinamide for the treatment of heart failure with preserved ejection fraction.

Comparison of levosimendan, NO, and inhaled iloprost for pulmonary hypertension reversibility assessment in heart transplant candidates.

Left ventricular reverse remodeling and function by strain analysis in aortic stenosis: A CMR analysis of the EPICHEART study.

Sodium-glucose co-transporter inhibitors in insulin-treated diabetes: a meta-analysis.

Metformin in non-diabetic patients with metabolic syndrome and diastolic dysfunction: the MET-DIME randomized trial.

Inflammatory Gene Expression of Human Perivascular Adipose Tissue in Abdominal Aortic Aneurysms.

Arterial Stiffness Changes in Severe Aortic Stenosis Patients Submitted to Valve Replacement Surgery.

Gastric microbiome profile throughout gastric carcinogenesis: beyond helicobacter.

Urocortin-2 in Acute Heart Failure: Role as a Marker of Volume Overload and Pulmonary Hypertension.

Assessing the influence of perfusion on cardiac microtissue maturation: A heart-on-chip platform embedding peristaltic pump capabilities.

Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases.

Human umbilical cord tissue-derived mesenchymal stromal cells as adjuvant therapy for myocardial infarction: a review of current evidence focusing on pre-clinical large animal models and early human trials.

Multiple versus single arterial grafting in the elderly: a meta-analysis of randomized controlled trials and propensity score studies.

Interplay between worsening kidney function and cardiovascular events in patients with type 2 diabetes: an analysis from the ACCORD trial.

Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction.

Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis.

Histological and haemodynamic characterization of right ventricle in sedentary and trained rats with heart failure with preserved ejection fraction.

A systematic review and meta-analysis of randomized controlled studies comparing off-pump versus on-pump coronary artery bypass grafting in the elderly.

Impact of oral anticoagulation therapy on postoperative atrial fibrillation outcomes: a systematic review and meta-analysis.

Myocardial stretch-induced compliance is abrogated under ischemic conditions and restored by cGMP/PKG-related pathways.

Sexual dimorphism in cardiac remodeling: the molecular mechanisms ruled by sex hormones in the heart.

Frailty-Independent Undertreatment Negative Impact on Survival in Older Patients With Breast Cancer.

Urocortins as biomarkers in cardiovascular disease.

Heart Failure with Preserved Ejection Fraction: a Pharmacotherapeutic Update.

Myocardial oedema: pathophysiological basis and implications for the failing heart.

Pericardial Fluid Annexin A1 Is a Marker of Atrial Fibrillation in Aortic Stenosis: A Proteomics Analysis.

Fenofibrate and Heart Failure Outcomes in Patients With Type 2 Diabetes: Analysis From ACCORD.

Effect of glucagon-like peptide-1 receptor agonists on cardiovascular events in overweight or obese adults without diabetes: A meta-analysis of placebo-controlled randomized trials.

Application of Proteogenomics to Urine Analysis towards the Identification of Novel Biomarkers of Prostate Cancer: An Exploratory Study.

Pulmonary Valve Replacement: A New Paradigm with Tissue Engineering.

Myogenic Underactive Bladder and Heart Failure Resemblance: A Novel Role for SGLT2 Inhibition?

Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis.

Cancer- and cardiac-induced cachexia: same fate through different inflammatory mediators?

Relaxin-2, pathophysiological insights and outcomes in heart failure with preserved ejection fraction: Findings from the NETDiamond cohort.

An overlap-weighted analysis on 10-year survival of off-pump versus on-pump coronary artery grafting in multivessel coronary artery disease.

Long-term survival of single versus bilateral internal mammary artery grafting in patients under 70.

Albiglutide in patients with type 2 diabetes and heart failure: a post-hoc analysis from Harmony Outcomes.

Prognostic implications of fibrosis in low risk aortic stenosis patients.

Risk of adverse events with liraglutide in heart failure with reduced ejection fraction: A post hoc analysis of the FIGHT trial.

Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure.

Long-term survival of female versus male patients after coronary artery bypass grafting.

Interleukin-6, infection and cardiovascular outcomes in acute heart failure: Findings from the EDIFICA registry.

Exercise training counteracts the cardiac metabolic remodelling induced by experimental pulmonary arterial hypertension.

The Use of Radiomic Analysis in Cardiovascular Diseases.

Aortic Valve Surgery in Patients with Infective Endocarditis: Mid-Term Follow-up of Patients Treated With the ST. Jude Medical Trifecta Valve.

Candidate microRNAs as prognostic biomarkers in heart failure: A systematic review.

Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS.

Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study.

Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction.

Galectin-3 in prostate cancer and heart diseases: a biomarker for these two frightening pathologies?

Glucagon-like peptide 1 receptor agonists in patients with type 2 diabetes with and without chronic heart failure: A meta-analysis of randomized placebo-controlled outcome trials.

Door-to-furosemide time and clinical outcomes in acute heart failure.

The impact of time-of-day reperfusion on remote ischemic conditioning in ST-elevation myocardial infarction: a RIC-STEMI substudy.

National registries for rare clinical conditions: Networking to promote evidence-based healthcare.

The PERInatal MYocardial Remodeling (PERIMYR) cohort study protocol: A prospective study of cardiac remodeling and "recovery" in pregnancy as a model to understand the impact of comorbidities in cardiac remodeling and reverse remodeling.

Exercise training impacts skeletal muscle remodelling induced by metabolic syndrome in ZSF1 rats through metabolism regulation.

Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction.

Changes in health-related quality of life and treatment effects in chronic heart failure: a meta-analysis.

A prospective study on varicose veins surgery impact on systemic endothelial function evaluated by arterial brachial flow mediated dilation.

Clinical and Pathophysiologic Insights of Free triiodothyronine/Free thyroxine Ratio in Patients with Heart Failure with Preserved Ejection Fraction: Data from the NETDiamond Cohort.

Human-umbilical cord matrix mesenchymal cells improved left ventricular contractility independently of infarct size in swine myocardial infarction with reperfusion.

Glucagon-like peptide-1 receptor agonists across the spectrum of heart failure.

Cardiovascular risk factors during pregnancy impact the postpartum cardiac and vascular reverse remodeling.

The impact of echocardiographic indexation to evaluate cardiac reverse remodeling throughout pregnancy and postpartum.

Predictive Risk Score for Acute Kidney Injury in Hematopoietic Stem Cell Transplant.

The Association between Gestational Diabetes and the Microbiome: A Systematic Review and Meta-Analysis.

GLP-1 Receptor Agonist Therapy With and Without SGLT2 Inhibitors in Patients With Type 2 Diabetes.

Myocardial RNA Sequencing Reveals New Potential Therapeutic Targets in Heart Failure with Preserved Ejection Fraction.

Body mass index effect on long-term survival after coronary artery bypass surgery: a competing risk analysis.