Amy L. Winship

Development and Stem Cells Program,
Monash Biomedicine Discovery Institute,
and Department of Anatomy and Developmental Biology,
Development and Stem Cells Program, Monash Biomedicine Discovery Institute, and Department of Anatomy and Developmental Biology,
Biomedicine Discovery Institute,
Department of Anatomy and Developmental Biology,
Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology

Monash University

BIOGRAPHY

Dr Winship is an Australian Research Council DECRA Fellow (2021-2023) in the Ovarian Biology Laboratory at Monash Biomedicine Discovery Institute.

She obtained her PhD in 2016 at the Hudson Institute of Medical Research, focused on defining the role of cytokines in the female reproductive tract and reproductive cancer.

Her current research examines the essential role of DNA repair capacity in regulating quality control of the female germline. She recently revealed the first evidence for a key role of intrinsic DNA break repair in response to endogenous DNA damage (i.e. resulting from normal cellular processes) to safeguard primordial oocyte number, genetic integrity and reproductive capacity.

Additionally, she is establishing her own research niche, capitalising on her background in uterine and placental biology, as well as oncofertility. This research addresses a fundamental knowledge gap, largely ignored by the fertility preservation field – do cancer therapies damage the uterus?

Her research is highly relevant to population health in Australia in context of fertility of female cancer survivors and maternal ageing.

PUBLICATIONS

Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice.

PloS one , 2015 | Pubmed ID: 26317527

Interleukin-11 alters placentation and causes preeclampsia features in mice.

Proceedings of the National Academy of Sciences of the United States of America Dec, 2015 | Pubmed ID: 26655736

Targeting Interleukin-11 Receptor-α Impairs Human Endometrial Cancer Cell Proliferation and Invasion In Vitro and Reduces Tumor Growth and Metastasis In Vivo.

Molecular cancer therapeutics 04, 2016 | Pubmed ID: 26846819

The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing.

Human reproduction update Mar, 2018 | Pubmed ID: 29377997

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age.

Scientific reports 04, 2018 | Pubmed ID: 29695822

Maternal low-protein diet programmes low ovarian reserve in offspring

Reproduction (Cambridge, England) 10, 2018 | Pubmed ID: 29991566

Maternal low-protein diet programmes low ovarian reserve in offspring

Reproduction (Cambridge, England) 10, 2018 | Pubmed ID: 30306601

Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice.

Toxicological sciences : an official journal of the Society of Toxicology 05, 2019 | Pubmed ID: 30657998

Do cancer therapies damage the uterus and compromise fertility?

Human reproduction update Feb, 2020 | Pubmed ID: 31863097

The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation.

Human reproduction (Oxford, England) Aug, 2020 | Pubmed ID: 32604417

Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade.

Cancer investigation , 2016 | Pubmed ID: 26682635

Fibulin-5 localisation in human endometrial cancer shifts from epithelial to stromal with increasing tumour grade, and silencing promotes endometrial epithelial cancer cell proliferation.

Oncology letters Jul, 2016 | Pubmed ID: 27347195

Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.

BMJ open 11, 2019 | Pubmed ID: 31772111

Comparison of methods for quantifying primordial follicles in the mouse ovary.

Journal of ovarian research Oct, 2020 | Pubmed ID: 33054849

Prolonged atrazine exposure beginning and adult uterine morphology in mice.

Journal of developmental origins of health and disease Feb, 2022 | Pubmed ID: 33781367

Development of an embryo transfer model to study uterine contributions to pregnancy in mice.

Reproduction & fertility Jan, 2022 | Pubmed ID: 35198982

Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice.

Nature cancer Aug, 2022 | Pubmed ID: 36008687

Melatonin as an oncostatic agent: Review of the modulation of tumor microenvironment and overcoming multidrug resistance.

Biochimie Nov, 2022 | Pubmed ID: 36116742

Does single-strand DNA break repair capacity influence oocyte maintenance and quality?

Reproduction (Cambridge, England) Dec, 2022 | Pubmed ID: 36215096

Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life.

Human reproduction update Feb, 2023 | Pubmed ID: 36857094

Radiotherapy exposure directly damages the uterus and causes pregnancy loss.

JCI insight Mar, 2023 | Pubmed ID: 36946464

INSTITUTIONS

Monash University

JOVE ARTICLES

Accurate Follicle Enumeration in Adult Mouse Ovaries

Amy L. Winship¹,

Urooza C. Sarma¹,

Lauren R. Alesi¹,

Karla J. Hutt¹

¹Development and Stem Cells Program, Monash Biomedicine Discovery Institute, and Department of Anatomy and Developmental Biology, Monash University

Developmental Biology

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Meaghan J. Griffiths^*,1,2,

Jordan N. Higgins^*,1,

Fiona L. Cousins³,

Lauren R. Alesi¹,

Amy L. Winship^*,1,

Karla J. Hutt^*,1

¹Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University,

²Gynaecology Research Centre, Royal Women’s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne,

³The Ritchie Centre, Hudson Institute for Medical Research and Department of Obstetrics and Gynaecology, Monash University

Developmental Biology

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