Bernhard Bettler

A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.

Distinct localization of GABA(B) receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus.

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.

Ligands for expression cloning and isolation of GABA(B) receptors.

Altered expression of GABAB receptors in the hippocampus after kainic-acid-induced seizures in rats.

GABA(B) receptors as potential therapeutic targets.

Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses.

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.

Glioblastomas on the move.

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.

Molecular structure and physiological functions of GABA(B) receptors.

Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain.

Altered hippocampal expression of calbindin-D-28k and calretinin in GABA(B(1))-deficient mice.

Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.

Floxed allele for conditional inactivation of the GABAB(1) gene.

Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA.

Effect of androgens on sexual differentiation of pituitary gamma-aminobutyric acid receptor subunit GABA(B) expression.

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.

The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function.

Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.

Expression of gamma-aminobutyric acid B receptor subunits in hypothalamus of male and female developing rats.

Adenohypophyseal and hypothalamic GABA B receptor subunits are downregulated by estradiol in adult female rats.

Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.

Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells.

Molecular diversity, trafficking and subcellular localization of GABAB receptors.

GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function.

Differential compartmentalization and distinct functions of GABAB receptor variants.

The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons.

WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes.

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition.

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

GABA(B) receptors: synaptic functions and mechanisms of diversity.

Specific roles of GABA(B(1)) receptor isoforms in cognition.

Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.

Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death.

Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes.

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.

Functional mapping of GABA(B)-receptor subtypes in the thalamus.

Trace amine-associated receptor 1 modulates dopaminergic activity.

Altered peripheral myelination in mice lacking GABAB receptors.

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function.

Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers.

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses.

Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.

The pros of not being competitive.

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice.

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

A mouse model for visualization of GABA(B) receptors.

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo.

Lack of functional GABA(B) receptors alters GnRH physiology and sexual dimorphic expression of GnRH and GAD-67 in the brain.

The Sushi domains of GABAB receptors function as axonal targeting signals.

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits.

NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1.

GABAB receptors: physiological functions and mechanisms of diversity.

Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling.

Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation.

Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.

The oligomeric state sets GABA(B) receptor signalling efficacy.

Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.

A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters.

Early-life stress induces visceral hypersensitivity in mice.

Regulation of neuronal GABA(B) receptor functions by subunit composition.

Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABA(B1) knockout mice.

Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.

GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.

Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization.

Constitutive Notch2 signaling induces hepatic tumors in mice.

GABAB receptor subtypes differentially modulate synaptic inhibition in the dentate gyrus to enhance granule cell output.

Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity.

Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors.

Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons.

Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12).

Activation of presynaptic GABA(B(1a,2)) receptors inhibits synaptic transmission at mammalian inhibitory cholinergic olivocochlear-hair cell synapses.

Lack of functional GABAB receptors alters Kiss1 , Gnrh1 and Gad1 mRNA expression in the medial basal hypothalamus at postnatal day 4.

GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet.

GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.

Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice.

Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers.

Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.

Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization.

GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization.

Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress.

Pharmacological characterization of GABAB receptor subtypes assembled with auxiliary KCTD subunits.

GABAB(1) receptor subunit isoforms differentially regulate stress resilience.

Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.

Mechanisms of fast desensitization of GABA(B) receptor-gated currents.

GABA blocks pathological but not acute TRPV1 pain signals.

Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.

GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks.

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers.

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics.

Presynaptic GABAB Receptors Regulate Hippocampal Synapses during Associative Learning in Behaving Mice.

KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons.

Presynaptic Excitation via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression.