Choon Nam Ong

Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese.

Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes.

Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality.

Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HEPG(2) cells.

Biomarkers for male reproductive health hazards: are they available?

Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and alpha1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa.

Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG1: a study of adolescents in a high risk region for hepatocellular carcinoma in China.

Simultaneous determination of tocotrienols, tocopherols, retinol, and major carotenoids in human plasma.

A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2'-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction.

Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms.

Increased iron staining in the cerebral cortex of cholesterol fed rabbits.

Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells.

Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB.

Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.

Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells.

Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells.

Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway.

Monomeric C18 chromatographic method for the liquid chromatographic determination of lipophilic antioxidants in plants.

Omega-3 fatty acids and selenium as coronary heart disease risk modifying factors in Asian Indian and Chinese males.

beta-Phenylethyl isothiocyanate mediated apoptosis: a proteomic investigation of early apoptotic protein changes.

Occupational health response to SARS.

A sensitive liquid chromatographic method for the spectrophotometric determination of urinary trans,trans-muconic acid.

Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.

Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.

Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms.

Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways.

Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells.

Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells.

Protective effects of Asian green vegetables against oxidant induced cytotoxicity.

Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis.

Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells.

Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.

Zinc supplementation decreases the development of atherosclerosis in rabbits.

Anti-cancer properties of anthraquinones from rhubarb.

Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS.

Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway.

Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries.

Qualitative and quantitative analysis of toosendanin in Melia toosendan Sieb. Et Zucc (Meliaceae) with liquid chromatography/tandem mass spectrometry.

Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization.

Association of blood lead and homocysteine levels among lead exposed subjects in Vietnam and Singapore.

Autophagy plays a protective role during zVAD-induced necrotic cell death.

Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.

Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and (1)H NMR spectroscopy.

Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation.

Peroxyl radical scavenging capacity, polyphenolics, and lipophilic antioxidant profiles of mulberry fruits cultivated in southern China.

Elevated oxidative stress, iron accumulation around microvessels and increased 4-hydroxynonenal immunostaining in zone 1 of the liver acinus in hypercholesterolemic rabbits.

A multi-analytical approach for metabolomic profiling of zebrafish (Danio rerio) livers.

Comprehensive high-performance liquid chromatographic method for the measurements of lipophilic antioxidants in human plasma.

Limited antioxidant effect after consumption of a single dose of tomato sauce by young males, despite a rise in plasma lycopene.

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy.

Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry.

Combination of 1H nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry with pattern recognition techniques for evaluation of metabolic profile associated with albuminuria.

Use of liquid chromatography/tandem mass spectrometry and online databases for identification of phosphocholines and lysophosphatidylcholines in human red blood cells.

Multiorigination of chromatographic peaks in derivatized GC/MS metabolomics: a confounder that influences metabolic pathway interpretation.

Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin.

Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats.

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.

Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis.

Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study.

Autophagy and oxidative stress associated with gold nanoparticles.

Characterization, purification, and stability of gold nanoparticles.

Anticancer effects of aloe-emodin on HepG2 cells: Cellular and proteomic studies.

Genomic instability of gold nanoparticle treated human lung fibroblast cells.

Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: general principles and applications.

The induction of epigenetic regulation of PROS1 gene in lung fibroblasts by gold nanoparticles and implications for potential lung injury.

Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish.

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells.

Plasma vitamin E and coenzyme Q10 are not associated with a lower risk of acute myocardial infarction in Singapore Chinese adults.

Metabolomics reveals altered metabolic pathways in experimental asthma.

Metabolomics studies show dose-dependent toxicity induced by SiO(2) nanoparticles in MRC-5 human fetal lung fibroblasts.

Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry.

Occurrence of regulated and emerging iodinated DBPs in the Shanghai drinking water.

Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics.

The effect of primary particle size on biodistribution of inhaled gold nano-agglomerates.

Exploratory investigation of plasma metabolomics in human lung adenocarcinoma.

Serum metabolome and lipidome changes in adult patients with primary dengue infection.

Exploratory investigation reveals parallel alteration of plasma fatty acids and eicosanoids in coronary artery disease patients.

Significant biochemical, biophysical and metabolic diversity in circulating human cord blood reticulocytes.

Toxicological profile of small airway epithelial cells exposed to gold nanoparticles.

Does high-dose coenzyme Q10 improve oxidative damage and clinical outcomes in Parkinson's disease?

Impact of elevated Ca(2+)/Mg(2+) concentrations of reverse osmosis membrane desalinated seawater on the stability of water pipe materials.

Toxicity profiling of water contextual zinc oxide, silver, and titanium dioxide nanoparticles in human oral and gastrointestinal cell systems.

Metabolic profiling of plasma from benign and malignant pulmonary nodules patients using mass spectrometry-based metabolomics.

Combination of in situ preconcentration and on-site analysis for phosphate monitoring in fresh waters.

HILIC-MS for metabolomics: An attractive and complementary approach to RPLC-MS.

Engineering noble metal nanomaterials for environmental applications.

Pro-inflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles.

Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma.

Degradation of the Common Aqueous Antibiotic Tetracycline using a Carbon Nanotube Electrochemical Filter.

Removal of Microcystis aeruginosa using nano-Fe3O4 particles as a coagulant aid.

MetTailor: dynamic block summary and intensity normalization for robust analysis of mass spectrometry data in metabolomics.

Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells.

Oxidative stress by inorganic nanoparticles.

Associations between Urinary Excretion of Cadmium and Renal Biomarkers in Nonsmoking Females: A Cross-Sectional Study in Rural Areas of South China.

MicroRNAs as biomarkers of hepatotoxicity in a randomized placebo-controlled study of simvastatin and ubiquinol supplementation.

Associations of serum organohalogen levels and prostate cancer risk: Results from a case-control study in Singapore.

A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.

Plasma α-Linolenic and Long-Chain ω-3 Fatty Acids Are Associated with a Lower Risk of Acute Myocardial Infarction in Singapore Chinese Adults.

Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma.

Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever.

Gold nanocluster sensitized TiO2 nanotube arrays for visible-light driven photoelectrocatalytic removal of antibiotic tetracycline.

Metabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia.

Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study.

Metabolic signatures and risk of type 2 diabetes in a Chinese population: an untargeted metabolomics study using both LC-MS and GC-MS.

Dietary predictors and plasma concentrations of perfluorinated alkyl acids in a Singapore population.

Consumption of Red Meat, but Not Cooking Oils High in Polyunsaturated Fat, Is Associated with Higher Arachidonic Acid Status in Singapore Chinese Adults.

Metabolic responses of the growing Daphnia similis to chronic AgNPs exposure as revealed by GC-Q-TOF/MS and LC-Q-TOF/MS.

Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and .

Biological effect of aqueous C aggregates on Scenedesmus obliquus revealed by transcriptomics and non-targeted metabolomics.

Biomedical Applications of Nanomaterials as Therapeutics.

Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection.

Meat and Seafood Consumption in Relation to Plasma Metabolic Profiles in a Chinese Population: A Combined Untargeted and Targeted Metabolomics Study.

Relative Validity and Reproducibility of a Food Frequency Questionnaire for Assessing Dietary Intakes in a Multi-Ethnic Asian Population Using 24-h Dietary Recalls and Biomarkers.

Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease.

Serum Lipids in Association With Type 2 Diabetes Risk and Prevalence in a Chinese Population.

Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection.

Comparison of hepatic and serum lipid signatures in hepatocellular carcinoma patients leads to the discovery of diagnostic and prognostic biomarkers.

Profiling of Phenolic Compounds and Antioxidant Activity of 12 Cruciferous Vegetables.

Plasma fatty acids and risk of colon and rectal cancers in the Singapore Chinese Health Study.

Detection of Lung Cancer: Concomitant Volatile Organic Compounds and Metabolomic Profiling of Six Cancer Cell Lines of Different Histological Origins.

Metabolite changes behind faster growth and less reproduction of Daphnia similis exposed to low-dose silver nanoparticles.

Occurrence and distribution of pesticides in precipitation as revealed by targeted screening through GC-MS/MS.

The use of as a model organism to study immune-nanotoxicity.

Metabolites change of Scenedesmus obliquus exerted by AgNPs.

Characterization of Plant Volatiles Reveals Distinct Metabolic Profiles and Pathways among 12 Brassicaceae Vegetables.

Use of an integrated metabolomics platform for mechanistic investigations of three commonly used algaecides on cyanobacterium, Microcystis aeruginosa.

Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population.

Reproducibility of Dietary Biomarkers in a Multiethnic Asian Population.

Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases.

Metabolic signatures of four major histological types of lung cancer cells.

Impacts of peat-forest smoke on urban PM in the Maritime Continent during 2012-2015: Carbonaceous profiles and indicators.

Employing multi-omics to elucidate the hormetic response against oxidative stress exerted by nC on Daphnia pulex.

Dydrogesterone exposure induces zebrafish ovulation but leads to oocytes over-ripening: An integrated histological and metabolomics study.

Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells.

Male-biased zebrafish sex differentiation and metabolomics profile changes caused by dydrogesterone.

A Dietary Pattern Derived from Reduced Rank Regression and Fatty Acid Biomarkers Is Associated with Lower Risk of Type 2 Diabetes and Coronary Artery Disease in Chinese Adults.

Simultaneous Quantification of 22 Glucosinolates in 12 Vegetables by Hydrophilic Interaction Chromatography-Tandem Mass Spectrometry.

Association between serum heavy metals and prostate cancer risk - A multiple metal analysis.

Association between maternal carotenoids, vitamin A and vitamin E levels and allergic outcomes in the offspring in the first 5 years of life.