Daniel A. Patten

National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research,
Institute of Immunology and Immunotherapy,
National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy

University of Birmingham

BIOGRAPHY

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PUBLICATIONS

Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury.

Proceedings of the National Academy of Sciences of the United States of America 08, 2016 | Pubmed ID: 27474165

NOTCH1 mediates a switch between two distinct secretomes during senescence.

Nature cell biology 09, 2016 | Pubmed ID: 27525720

Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration.

Hepatology (Baltimore, Md.) 01, 2017 | Pubmed ID: 27770554

CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma.

American journal of physiology. Gastrointestinal and liver physiology Aug, 2017 | Pubmed ID: 28473332

Commensal-derived OMVs elicit a mild proinflammatory response in intestinal epithelial cells.

Microbiology (Reading, England) 05, 2017 | Pubmed ID: 28530169

SCARF-1 promotes adhesion of CD4 T cells to human hepatic sinusoidal endothelium under conditions of shear stress.

Scientific reports 12, 2017 | Pubmed ID: 29242513

Chronic liver disease: scavenger hunt for novel therapies.

Lancet (London, England) 01, 2018 | Pubmed ID: 29353605

SCARF1: a multifaceted, yet largely understudied, scavenger receptor.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] Aug, 2018 | Pubmed ID: 29725698

More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking.

Frontiers in immunology , 2018 | Pubmed ID: 30631321

Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases.

Seminars in liver disease May, 2019 | Pubmed ID: 30912097

Erratum: Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases.

Seminars in liver disease 05, 2019 | Pubmed ID: 30991424

Tumour-associated macrophages in hepatocellular carcinoma: Pressing the metabolic switch to prevent T cell responses.

Journal of hepatology 08, 2019 | Pubmed ID: 31208893

The Role of Stabilin-1 in Lymphocyte Trafficking and Macrophage Scavenging in the Liver Microenvironment.

Biomolecules 07, 2019 | Pubmed ID: 31315308

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.

Nature communications 04, 2020 | Pubmed ID: 32321925

Prognostic Value and Potential Immunoregulatory Role of SCARF1 in Hepatocellular Carcinoma.

Frontiers in oncology , 2020 | Pubmed ID: 34354939

Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer.

Seminars in liver disease Sep, 2021 | Pubmed ID: 34553345

INSTITUTIONS

University of Birmingham

JOVE ARTICLES

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Marco Y. W. Zaki^*,1,2,

Shishir Shetty^*,2,

Alex L. Wilkinson²,

Daniel A. Patten²,

Fiona Oakley^*,3,

Helen Reeves^*,4,5

¹Department of Biochemistry, Faculty of Pharmacy, Minia University,

²National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham,

³Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University,

⁴Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University,

⁵The Liver Unit, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust

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