Giuseppe Valacchi

F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome.

Scavenger receptor class B type I: a multifunctional receptor.

Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil.

Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation.

Calorie restriction with a high-fat diet effectively attenuated inflammatory response and oxidative stress-related markers in obese tissues of the high diet fed rats.

Arginine-based inhibitors of nitric oxide synthase: therapeutic potential and challenges.

Cutaneous responses to environmental stressors.

Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy.

Scavenger receptor B1 post-translational modifications in Rett syndrome.

17-β-Estradiol counteracts the effects of high frequency electromagnetic fields on trophoblastic connexins and integrins.

Antiangiogenic VEGF isoform in inflammatory myopathies.

Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder.

Incorporation of quercetin in respirable lipid microparticles: effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells.

Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract.

Effect of nanostructured lipid vehicles on percutaneous absorption of curcumin.

Innovative approaches in environmental medicine: redox/detoxification biomarkers in environmental intolerances.

Effects of ω-3 polyunsaturated fatty acids on plasma proteome in Rett syndrome.

Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients.

Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism.

A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant.

Subclinical inflammatory status in Rett syndrome.

Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment.

Effect of combined mulberry leaf and fruit extract on liver and skin cholesterol transporters in high fat diet-induced obese mice.

Beta-actin deficiency with oxidative posttranslational modifications in Rett syndrome erythrocytes: insights into an altered cytoskeletal organization.

The Magic Velvet Bean of Mucuna pruriens.

Inflammatory lung disease in Rett syndrome.

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome.

ASD: biochemical mechanisms behind behavioral disorders.

Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells.

Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome.

Resveratrol prevents cigarette smoke-induced keratinocytes damage.

Cholesterol metabolism is altered in Rett syndrome: a study on plasma and primary cultured fibroblasts derived from patients.

Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation.

Successful aging, dietary habits and health status of elderly individuals: a k-dimensional approach within the multi-national MEDIS study.

Protective effect of palmitoylethanolamide in a rat model of cystitis.

Synthesis and evaluation of indole based molecules for treatment of oxidative stress related diseases.

Nrf2 activation as target to implement therapeutic treatments.

Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis.

The loss of cellular junctions in epithelial lung cells induced by cigarette smoke is attenuated by corilagin.

Effect of new curcumin-containing nanostructured lipid dispersions on human keratinocytes proliferative responses.

The Role of Energy Balance in Successful Aging Among Elderly Individuals: The Multinational MEDIS Study.

Exploring the possible link between MeCP2 and oxidative stress in Rett syndrome.

Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder.

Integrated Haematological Profiles of Redox Status, Lipid, and Inflammatory Protein Biomarkers in Benign Obesity and Unhealthy Obesity with Metabolic Syndrome.

Antiproliferative Effect of Rottlerin on Sk-Mel-28 Melanoma Cells.

Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage.

Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis.

Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection.

Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.

Scavenger Receptor B1 oxidative post-translational modifications are responsible for its loss in Rett syndrome.

Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients.

Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome.

Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure.

Oxidative challenge in Alzheimer's disease: state of knowledge and future needs.

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.

Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application.

Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD).

Is Parental Longevity Associated With the Cardiovascular Risk and the Successful Aging of Their Offspring? Results From the Multinational MEDIS Study.

Skeletal muscle mass and body fat in relation to successful ageing of older adults: The multi-national MEDIS study.

Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases.

Successful Aging among Elders Living in the Mani Continental Region vs. Insular Areas of the Mediterranean: the MEDIS Study.

OxInflammation in Rett syndrome.

Association between circulatory levels of adipokines and bone mineral density in postmenopausal women.

Ozone mediators effect on "in vitro" scratch wound closure.

Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts.

Redox regulation of inflammatory processes.

SRB1 as a new redox target of cigarette smoke in human sebocytes.

Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress.

4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation.

Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.

Nanostructured lipid carriers (NLC) for the delivery of natural molecules with antimicrobial activity: production, characterisation and in vitro studies.

The Impact of the Financial Crisis on Lifestyle Health Determinants Among Older Adults Living in the Mediterranean Region: The Multinational MEDIS Study (2005-2015).

Is car use related with successful aging of older adults? Results from the multinational Mediterranean islands study.

Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin.

Monoolein aqueous dispersions as a delivery system for quercetin.

Mediterranean lifestyle and cardiovascular disease prevention.

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.

Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation.

Circadian clock as possible protective mechanism to pollution induced keratinocytes damage.

Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome.

Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure.

Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women.

Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study.

Role of Nrf2 in preventing oxidative stress induced chloride current alteration in human lung cells.

Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment.

Lactonase Activity and Lipoprotein-Phospholipase A as Possible Novel Serum Biomarkers for the Differential Diagnosis of Autism Spectrum Disorders and Rett Syndrome: Results from a Pilot Study.

Influences of the vehicle in the spreading and release of betamethasone.

Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia.

Atmospheric skin aging-Contributors and inhibitors.

Lifestyle determinants of healthy ageing in a Mediterranean population: The multinational MEDIS study.

Mediterranean diet and depression among older individuals: The multinational MEDIS study.

Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing.

OxInflammation: From Subclinical Condition to Pathological Biomarker.

Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells.

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.

TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress.

Bone status in relation to ambulatory performance in girls with Rett syndrome: a 10-year longitudinal study.

SR-B1 involvement in keratinocytes in vitro wound closure.

Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer's Disease.

Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development.

Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence.

Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes.

13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation.

Antiglycative Activity and RAGE Expression in Rett Syndrome.

Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current.

Involvement of cutaneous SR-B1 in skin lipid homeostasis.

Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage.

Ozonated Oils and Cutaneous Wound Healing.

Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells.

Lipid nanostructures for antioxidant delivery: a comparative preformulation study.

Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.

Proinflammatory properties and oxidative effects of atmospheric particle components in human keratinocytes.

Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation.

Mimicking cigarette smoke exposure to assess cutaneous toxicity.

Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study.

Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease.

Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes.

Redox regulation of cutaneous inflammasome by ozone exposure.

Skin Health from the Inside Out.

HelixComplex snail mucus as a potential technology against O3 induced skin damage.

Compromised immune/inflammatory responses in Rett syndrome.

Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery.

Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder.

The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways.

Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations.

Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation.

Circadian Clock and OxInflammation: Functional Crosstalk in Cutaneous Homeostasis.

Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model.

Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid.

Particulate Matter Induces Tissue OxInflammation: From Mechanism to Damage.

Proteomic profiling reveals mitochondrial alterations in Rett syndrome.

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria.

Ethosomes for Coenzyme Q10 Cutaneous Administration: From Design to 3D Skin Tissue Evaluation.

Evaluation of oxidative damage and Nrf2 activation by combined pollution exposure in lung epithelial cells.

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies.

KRIT1 as a possible new player in melanoma aggressiveness.

NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate matter.

Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation.

Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease.

Postexercise Inflammasome Activation and IL-1β Production Mitigated by Flavonoid Supplementation in Cyclists.

SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?

Bench approaches to study the detrimental cutaneous impact of tropospheric ozone.

A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome.

Evaluating the effect of ozone in UV induced skin damage.

Inflammasome Activation in Pollution-Induced Skin Conditions.

Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer's Disease: A Narrative Review.

Impaired mitochondrial quality control in Rett Syndrome.

Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure.

Cutaneous antimicrobial peptides: New "actors" in pollution related inflammatory conditions.

Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents.

BACE1 role in Alzheimer's disease and other dementias: from the theory to the practice.

BACE1: from biomarker to Alzheimer's disease therapeutical target.