Jeffrey D. Varner

Systems biology and the mathematical modelling of antibody-directed enzyme prodrug therapy (ADEPT).

Stochastic reaction-diffusion simulation of enzyme compartmentalization reveals improved catalytic efficiency for a synthetic metabolic pathway.

Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies.

A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials.

Engineering the spatial organization of metabolic enzymes: mimicking nature's synergy.

Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems.

Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells.

Ensembles of signal transduction models using Pareto Optimal Ensemble Techniques (POETs).

Ensembles of uncertain mathematical models can identify network response to therapeutic interventions.

Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells.

Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells.

A review of the mammalian unfolded protein response.

Computational modeling and analysis of insulin induced eukaryotic translation initiation.

Multiscale models of breast cancer progression.

Hierarchical approaches for systems modeling in cardiac development.

The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells.

Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model.

Ubiquibodies, synthetic E3 ubiquitin ligases endowed with unnatural substrate specificity for targeted protein silencing.

Retinoic acid therapy resistance progresses from unilineage to bilineage in HL-60 leukemic blasts.

GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation.

Generating Effective Models and Parameters for RNA Genetic Circuits.

6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells.

Induced myelomonocytic differentiation in leukemia cells is accompanied by noncanonical transcription factor expression.

Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated Sp1.

JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language.

An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program.

Reduced order modeling and analysis of the human complement system.

Potential for subsets of wt-NPM1 primary AML blasts to respond to retinoic acid treatment.

Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells.

Sequence Specific Modeling of E. coli Cell-Free Protein Synthesis.

Dynamic Optimization with Particle Swarms (DOPS): a meta-heuristic for parameter estimation in biochemical models.

Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors.

Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML.

Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients.

Improving designer glycan production in through model-guided metabolic engineering.