Kristoffer Valerie

Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus.

Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells.

UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53.

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells.

SAGE transcript profiles of normal primary human hepatocytes expressing oncogenic hepatitis B virus X protein.

Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence.

Stress and radiation-induced activation of multiple intracellular signaling pathways.

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination.

Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.

Mood-enhancing antidepressant St. John's wort inhibits the activation of human immunodeficiency virus gene expression by ultraviolet light.

Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.

Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells.

Dominant-negative cAMP-responsive element-binding protein inhibits proliferating cell nuclear antigen and DNA repair, leading to increased cellular radiosensitivity.

Adenovirus expressing p53.

Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles.

MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.

EGFRvIII-mediated radioresistance through a strong cytoprotective response.

Regulation and mechanisms of mammalian double-strand break repair.

Triggering of apoptosis is not sufficient to induce human immunodeficiency virus gene expression.

Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression.

Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene.

Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy.

Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells.

Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.

Radiation-induced activation of a common variant of EGFR confers enhanced radioresistance.

Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity.

Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter.

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1).

Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2.

Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence.

Targeted virus replication plus immunotherapy eradicates primary and distant pancreatic tumors in nude mice.

Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein.

Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation.

mda-9/Syntenin: a positive regulator of melanoma metastasis.

Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis.

Molecular target-based therapy of pancreatic cancer.

ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells.

Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocytes.

BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis.

Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment.

N-glycosylation of MDA-7/IL-24 is dispensable for tumor cell-specific apoptosis and "bystander" antitumor activity.

Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.

辐射诱导细胞内信号传递： 内外和外而内。

Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts.

Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppression.

Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis.

Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase.

Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN).

In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells.

Nuclear factor I isoforms regulate gene expression during the differentiation of human neural progenitors to astrocytes.

Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts.

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.

Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.

ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells.

ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks.

Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.

DNA double-strand break - induced pro-survival signaling.

MRE11 and ATM AKTivate pro-survival signaling.

Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents.

BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.

Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.