Huffington Center on Aging,
Department of Molecular and Human Genetics,
Howard Hughes Medical Institute
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RNAi screening for fat regulatory genes with SRS microscopy.
Nature methods Feb, 2011 | Pubmed ID: 21240281
Label-free imaging of lipid dynamics using Coherent Anti-stokes Raman Scattering (CARS) and Stimulated Raman Scattering (SRS) microscopy.
Current opinion in genetics & development Oct, 2011 | Pubmed ID: 21945002
Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2013 | Pubmed ID: 23798434
Shedding new light on lipid functions with CARS and SRS microscopy.
Biochimica et biophysica acta Aug, 2014 | Pubmed ID: 24576891
Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering.
Nature methods Apr, 2014 | Pubmed ID: 24584195
In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy.
Journal of the American Chemical Society Jun, 2014 | Pubmed ID: 24869754
Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome.
American journal of human genetics Nov, 2014 | Pubmed ID: 25439098
Gene pathways that delay Caenorhabditis elegans reproductive senescence.
PLoS genetics Dec, 2014 | Pubmed ID: 25474471
Quantitative imaging of glutathione in live cells using a reversible reaction-based ratiometric fluorescent probe.
ACS chemical biology Mar, 2015 | Pubmed ID: 25531746
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
Science (New York, N.Y.) Jan, 2015 | Pubmed ID: 25554789
Label-free biomedical imaging of lipids by stimulated Raman scattering microscopy.
Current protocols in molecular biology Jan, 2015 | Pubmed ID: 25559108
Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.
Biochimica et biophysica acta Oct, 2015 | Pubmed ID: 26025681
Olfaction Modulates Reproductive Plasticity through Neuroendocrine Signaling in Caenorhabditis elegans.
Current biology : CB Aug, 2015 | Pubmed ID: 26279229
Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2015 | Pubmed ID: 26621724
Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide.
The Analyst Feb, 2016 | Pubmed ID: 26806071
MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death.
Genome medicine 11, 2016 | Pubmed ID: 27799064
Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling.
Nature cell biology May, 2017 | Pubmed ID: 28436966
Microbial Genetic Composition Tunes Host Longevity.
Cell Jun, 2017 | Pubmed ID: 28622510
Quantitative real-time imaging of glutathione.
Nature communications 07, 2017 | Pubmed ID: 28703127
The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance.
eNeuro May-Jun, 2017 | Pubmed ID: 28785723
Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria.
ACS sensors Sep, 2017 | Pubmed ID: 28809477
High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation.
Nature communications 10, 2017 | Pubmed ID: 29021566
Building multidisciplinary research.
Molecular biology of the cell Nov, 2017 | Pubmed ID: 29084905
Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications.
Antioxidants & redox signaling 08, 2018 | Pubmed ID: 29320869
Neuronal regulation of longevity by staying cool.
Genes & development 02, 2018 | Pubmed ID: 29491133
Fingerprint Stimulated Raman Scattering Imaging Reveals Retinoid Coupling Lipid Metabolism and Survival.
Chemphyschem : a European journal of chemical physics and physical chemistry 10, 2018 | Pubmed ID: 29911339
Aging: Antagonistic Pleiotropy Supported by Gut Eating.
Current biology : CB 08, 2018 | Pubmed ID: 30130513
Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution.
Antioxidants & redox signaling 06, 2019 | Pubmed ID: 30358421
'Inside Out'- a dialogue between mitochondria and bacteria.
The FEBS journal 02, 2019 | Pubmed ID: 30390412
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity.
Developmental cell 03, 2019 | Pubmed ID: 30713071
Does Autophagy Promote Longevity? It Depends.
Cell 04, 2019 | Pubmed ID: 30951663
The Bacterivore's Solution: Fight and Flight to Promote Survival.
Developmental cell 04, 2019 | Pubmed ID: 30965036
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8.
Scientific reports 07, 2019 | Pubmed ID: 31292465
Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes.
Hepatology (Baltimore, Md.) 03, 2020 | Pubmed ID: 31355949
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
Trends in cell biology 11, 2019 | Pubmed ID: 31611045
Metabolite Profiling Leads to the Development of an RNA Interference Strain for .
G3 (Bethesda, Md.) 01, 2020 | Pubmed ID: 31712257
Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans.
Nature communications 03, 2020 | Pubmed ID: 32193370
Molecular Mechanisms of Lysosome and Nucleus Communication.
Trends in biochemical sciences 11, 2020 | Pubmed ID: 32624271
Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry.
Nature communications 08, 2020 | Pubmed ID: 32848159
Optogenetic control of gut bacterial metabolism to promote longevity.
eLife 12, 2020 | Pubmed ID: 33325823
Glutathione Quantification in Live Cells with Real-Time Imaging and Flow Cytometry.
STAR protocols Dec, 2020 | Pubmed ID: 33377064
Lipid metabolism and lipid signals in aging and longevity.
Developmental cell May, 2021 | Pubmed ID: 33891896
Dissecting lipid droplet biology with coherent Raman scattering microscopy.
Journal of cell science Mar, 2022 | Pubmed ID: 33975358
3D genomics across the tree of life reveals condensin II as a determinant of architecture type.
Science (New York, N.Y.) May, 2021 | Pubmed ID: 34045355
Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart.
Proteomes Jun, 2021 | Pubmed ID: 34200203
FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology.
Aging cell Aug, 2021 | Pubmed ID: 34247441
Cracking genetic codes of longevity.
Nature reviews. Molecular cell biology Jan, 2022 | Pubmed ID: 34312517
Mitochondrial UPR through generations.
Nature cell biology Aug, 2021 | Pubmed ID: 34341530
Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems.
Antioxidants & redox signaling Feb, 2022 | Pubmed ID: 34521263
Author Correction: Mitochondrial UPR through generations.
Nature cell biology Oct, 2021 | Pubmed ID: 34526655
Host and microbiota metabolic signals in aging and longevity.
Nature chemical biology Oct, 2021 | Pubmed ID: 34552221
Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34926454
Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion.
Developmental cell Mar, 2022 | Pubmed ID: 35316617
Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases.
Expert opinion on therapeutic targets Apr, 2022 | Pubmed ID: 35426759
Lysosome lipid signalling from the periphery to neurons regulates longevity.
Nature cell biology Jun, 2022 | Pubmed ID: 35681008
Applications of covalent chemistry in targeted protein degradation.
Chemical Society reviews Nov, 2022 | Pubmed ID: 36285735
1Graduate Program in Developmental Biology, Baylor College of Medicine,
2Huffington Center on Aging, Baylor College of Medicine,
3Integrative Program of Molecular and Biochemical Sciences, Baylor College of Medicine,
4Department of Molecular and Human Genetics, Baylor College of Medicine,
5Howard Hughes Medical Institute, Baylor College of Medicine
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