Noah Weisleder

Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy.

Cardiomyocyte-specific desmin rescue of desmin null cardiomyopathy excludes vascular involvement.

Structural and functional roles of desmin in mouse skeletal muscle during passive deformation.

Alterations in the heart mitochondrial proteome in a desmin null heart failure model.

Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle.

Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice.

Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes.

Ca2+ sparks as a plastic signal for skeletal muscle health, aging, and dystrophy.

Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.

Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.

Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle.

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.

TRIC channels are essential for Ca2+ handling in intracellular stores.

The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis.

Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins.

Altered Ca2+ sparks in aging skeletal and cardiac muscle.

Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells.

Compromised store-operated Ca2+ entry in aged skeletal muscle.

A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization.

MG53 regulates membrane budding and exocytosis in muscle cells.

MG53 nucleates assembly of cell membrane repair machinery.

The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells.

Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin.

Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair.

S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.

Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications.

Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.

MG53 constitutes a primary determinant of cardiac ischemic preconditioning.

Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression.

Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms.

Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.

Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair.

Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.

A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice.

Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair.

Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.

Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.

Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling.

Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.

Store-operated calcium entry is present in HL-1 cardiomyocytes and contributes to resting calcium.

Detection of calcium sparks in intact and permeabilized skeletal muscle fibers.

Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair.

Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters.

Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy.

Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications.

Orai1 mediates exacerbated Ca(2+) entry in dystrophic skeletal muscle.

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

A dual mode pulsed electro-magnetic cell stimulator produces acceleration of myogenic differentiation.

TRIM proteins in therapeutic membrane repair of muscular dystrophy.

Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.