Noah Weisleder

Department of Physiology and Biophysics, Robert Wood Johnson Medical School

Affiliated withRobert Wood Johnson Medical School The Ohio State University Wexner Medical Center The Ohio State University

Research Area

BiologyMedicine

Biography

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JoVE Journal Publications

Article Total : 3	Year
Publication title	2011
Publication title	2014
Publication title	2014

Other Publications

Article	Year
Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14715896	2004
Cardiomyocyte-specific desmin rescue of desmin null cardiomyopathy excludes vascular involvement. Journal of molecular and cellular cardiology\| PubMed ID: 14734054	2004
Structural and functional roles of desmin in mouse skeletal muscle during passive deformation. Biophysical journal\| PubMed ID: 15111414	2004
Alterations in the heart mitochondrial proteome in a desmin null heart failure model. Journal of molecular and cellular cardiology\| PubMed ID: 15733906	2005
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nature cell biology\| PubMed ID: 15834406	2005
Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. Physiological genomics\| PubMed ID: 15998745	2005
Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophysical journal\| PubMed ID: 16565048	2006
Ca2+ sparks as a plastic signal for skeletal muscle health, aging, and dystrophy. Acta pharmacologica Sinica\| PubMed ID: 16787561	2006
Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. The Journal of cell biology\| PubMed ID: 16943181	2006
Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. The Journal of biological chemistry\| PubMed ID: 16945924	2006
Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle. Cell calcium\| PubMed ID: 17412417	2007
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. Journal of molecular and cellular cardiology\| PubMed ID: 17509612	2007
TRIC channels are essential for Ca2+ handling in intracellular stores. Nature\| PubMed ID: 17611541	2007
The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis. Journal of cell science\| PubMed ID: 17666431	2007
Immuno-proteomic approach to excitation--contraction coupling in skeletal and cardiac muscle: molecular insights revealed by the mitsugumins. Cell calcium\| PubMed ID: 18061662	2008
Altered Ca2+ sparks in aging skeletal and cardiac muscle. Ageing research reviews\| PubMed ID: 18272434	2008
Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells. Journal of pharmacological sciences\| PubMed ID: 18296864	2008
Compromised store-operated Ca2+ entry in aged skeletal muscle. Aging cell\| PubMed ID: 18505477	2008
A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18539904	2008
MG53 regulates membrane budding and exocytosis in muscle cells. The Journal of biological chemistry\| PubMed ID: 19029292	2009
MG53 nucleates assembly of cell membrane repair machinery. Nature cell biology\| PubMed ID: 19043407	2009
The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. American journal of physiology. Cell physiology\| PubMed ID: 19091958	2009
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin. The Journal of biological chemistry\| PubMed ID: 19380584	2009
Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair. Communicative & integrative biology\| PubMed ID: 19641737	2009
S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle. The Biochemical journal\| PubMed ID: 20095964	2010
Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications. Endocrinology\| PubMed ID: 20392835	2010
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circulation research\| PubMed ID: 20466981	2010
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation\| PubMed ID: 20516375	2010
Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression. Biophysical journal\| PubMed ID: 20816068	2010
Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms. The Journal of biological chemistry\| PubMed ID: 21189256	2011
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circulation. Heart failure\| PubMed ID: 21216834	2011
Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair. The Journal of biological chemistry\| PubMed ID: 21343302	2011
Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. Journal of neuropathology and experimental neurology\| PubMed ID: 21412170	2011
A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21518849	2011
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair. American journal of physiology. Cell physiology\| PubMed ID: 21525429	2011
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell research\| PubMed ID: 21556035	2011
Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle. Aging\| PubMed ID: 21666285	2011
Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. The Journal of biological chemistry\| PubMed ID: 21795684	2011
Disrupted membrane structure and intracellular CaÂ²âº signaling in adult skeletal muscle with acute knockdown of Bin1. PloS one\| PubMed ID: 21984944	2011
Store-operated calcium entry is present in HL-1 cardiomyocytes and contributes to resting calcium. Biochemical and biophysical research communications\| PubMed ID: 22079292	2011
Detection of calcium sparks in intact and permeabilized skeletal muscle fibers. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130850	2012
Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22253476	2012
Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in Î´-Sarcoglycan-deficient Hamsters. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22314291	2012
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Science translational medicine\| PubMed ID: 22723464	2012
Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications. Recent patents on biotechnology\| PubMed ID: 23092436	2012
Orai1 mediates exacerbated Ca(2+) entry in dystrophic skeletal muscle. PloS one\| PubMed ID: 23185465	2012
Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle. The Journal of biological chemistry\| PubMed ID: 23223241	2013
A dual mode pulsed electro-magnetic cell stimulator produces acceleration of myogenic differentiation. Recent patents on biotechnology\| PubMed ID: 23445453	2013
TRIM proteins in therapeutic membrane repair of muscular dystrophy. JAMA neurology\| PubMed ID: 23699904	2013
Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases. Frontiers in physiology\| PubMed ID: 24600395	2014