Patrick H. Maxwell

Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer.

Oxygen sensors and angiogenesis.

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.

Oxygen homeostasis and cancer: insights from a rare disease.

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.

Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy.

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia.

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

Evidence for hypoxia-induced neuronal-to-chromaffin metaplasia in neuroblastoma.

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

HIF and oxygen sensing; as important to life as the air we breathe?

HIF-1's relationship to oxygen: simple yet sophisticated.

Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene.

Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium.

Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors.

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.

Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families.

Is it rejection? Be on the lookout for 'decoys'.

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Manipulation of oxygen tensions for in vitro cell culture using a hypoxic workstation.

A common pathway for genetic events leading to pheochromocytoma.

Genetic evidence for a tumor suppressor role of HIF-2alpha.

The HIF pathway in cancer.

Hypoxia-inducible factor as a physiological regulator.

HIF, a missing link between metabolism and cancer.

Genetic studies of IgA nephropathy.

Effects of VHL deficiency on endolymphatic duct and sac.

Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia.

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.

Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy.

Correction of severe anaemia using immuno-regulated gene therapy is achieved by restoring the early erythroblast compartment.

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils.

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.

Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein.

Low oxygen stimulates the intellect. Symposium on hypoxia and development, physiology and disease.

Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.

Identification of multiple transcription initiation, polyadenylation, and splice sites in the Drosophila melanogaster TART family of telomeric retrotransposons.

Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney.

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.

Genetic insights into the hypoxia-inducible factor (HIF) pathway.

Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?

Host factors that control long terminal repeat retrotransposons in Saccharomyces cerevisiae: implications for regulation of mammalian retroviruses.

Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia.

Inadvertent postdialysis anticoagulation due to heparin line locks.

Expression of hypoxia-inducible factors in normal human lung development.

Retrosequence formation restructures the yeast genome.

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.

Role of Gas6 in erythropoiesis and anemia in mice.

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.

Developmental and tissue-specific accumulation pattern for the Drosophila melanogaster TART ORF1 protein.

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase-negative mutants.

Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease.

The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation.

Variations within oxygen-regulated gene expression in humans.

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin.

Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation.

Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells.

Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease.

Oxygen availability sHIFts the cell cycle.

Rrm3 protects the Saccharomyces cerevisiae genome from instability at nascent sites of retrotransposition.

Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression.

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection.

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin.

The role of HIF in immunity.

Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.

Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients.

Genetic loci influencing kidney function and chronic kidney disease.

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.

HLA has strongest association with IgA nephropathy in genome-wide analysis.

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis.

Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype.

VHL inactivation induces HEF1 and Aurora kinase A.

Hypoxia and upregulation of hypoxia-inducible factor 1{alpha} stimulate venous thrombus recanalization.

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation.

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension.

Copy number profiling in von Hippel-Lindau disease renal cell carcinoma.

Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease.

Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees.

Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.

Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues.

Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms.

Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.

Retrotransposition is associated with genome instability during chronological aging.

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.

Tumor strengths and frailties: Aspiring to prevent colon cancer.

The ERA-EDTA Working Group on inherited kidney disorders.

Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy.

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.

Increasing evidence that genetic variation in complement factor H related 5 (CFHR5) causes disease: a commentary on 'Atypical haemolytic uremic syndrome and genetic aberrations in the complement factor-H-related 5 gene'.

What happens to clinical training fellows? A retrospective study of the 20 years outcome of a Medical Research Council UK cohort.

C3 glomerulonephritis and CFHR5 nephropathy.

Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study.

Epistatic role of the MYH9/APOL1 region on familial hematuria genes.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition.

Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences.

The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.

Extension of Saccharomyces paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species.