Paul Timpson

A role for the actin cytoskeleton in cell death and aging in yeast.

Distinction at the leading edge of the cell.

Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor.

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex.

Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib.

Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin.

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma.

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.

Imaging molecular dynamics in vivo--from cell biology to animal models.

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion.

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression.