Phillip D. Zamore
Department of Biochemistry & Molecular Pharmacology and Howard Hughes Medical Institute
University of Massachusetts Medical School
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Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.
Current biology : CB May, 2009 | Pubmed ID: 19361997
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies.
Cell May, 2009 | Pubmed ID: 19395009
MicroRNAs: regulating a change of heart.
Circulation Apr, 2009 | Pubmed ID: 19398677
RNAi: nature abhors a double-strand.
Current opinion in genetics & development Apr, 2002 | Pubmed ID: 11893497
Why do miRNAs live in the miRNP?
Genes & development May, 2002 | Pubmed ID: 12000786
Ancient pathways programmed by small RNAs.
Science (New York, N.Y.) May, 2002 | Pubmed ID: 12016303
A microRNA in a multiple-turnover RNAi enzyme complex.
Science (New York, N.Y.) Sep, 2002 | Pubmed ID: 12154197
Modular recognition of RNA by a human pumilio-homology domain.
Cell Aug, 2002 | Pubmed ID: 12202039
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.
Molecular cell Sep, 2002 | Pubmed ID: 12408822
A biochemical framework for RNA silencing in plants.
Genes & development Jan, 2003 | Pubmed ID: 12514099
siRNAs knock down hepatitis.
Nature medicine Mar, 2003 | Pubmed ID: 12612573
In vitro analysis of RNA interference in Drosophila melanogaster.
Methods (San Diego, Calif.) Aug, 2003 | Pubmed ID: 12828947
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis.
Aging cell Aug, 2003 | Pubmed ID: 12934714
Asymmetry in the assembly of the RNAi enzyme complex.
Cell Oct, 2003 | Pubmed ID: 14567917
Biochemical dissection of RNA silencing in plants.
Methods in molecular biology (Clifton, N.J.) , 2004 | Pubmed ID: 14770009
Sequence-specific inhibition of small RNA function.
PLoS biology Apr, 2004 | Pubmed ID: 15024405
Plant RNAi: How a viral silencing suppressor inactivates siRNA.
Current biology : CB Mar, 2004 | Pubmed ID: 15028237
RISC assembly defects in the Drosophila RNAi mutant armitage.
Cell Mar, 2004 | Pubmed ID: 15035985
The RNA-induced silencing complex is a Mg2+-dependent endonuclease.
Current biology : CB May, 2004 | Pubmed ID: 15120070
Kinetic analysis of the RNAi enzyme complex.
Nature structural & molecular biology Jul, 2004 | Pubmed ID: 15170178
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region.
The EMBO journal Aug, 2004 | Pubmed ID: 15282547
A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe.
Genes & development Oct, 2004 | Pubmed ID: 15371329
A protein sensor for siRNA asymmetry.
Science (New York, N.Y.) Nov, 2004 | Pubmed ID: 15550672
MicroRNA biogenesis: drosha can't cut it without a partner.
Current biology : CB Jan, 2005 | Pubmed ID: 15668159
Perspective: machines for RNAi.
Genes & development Mar, 2005 | Pubmed ID: 15741316
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.
PLoS biology Jul, 2005 | Pubmed ID: 15918770
Ribo-gnome: the big world of small RNAs.
Science (New York, N.Y.) Sep, 2005 | Pubmed ID: 16141061
microPrimer: the biogenesis and function of microRNA.
Development (Cambridge, England) Nov, 2005 | Pubmed ID: 16224044
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.
Cell Nov, 2005 | Pubmed ID: 16271386
Rethinking the microprocessor.
Cell Jun, 2006 | Pubmed ID: 16751089
A distinct small RNA pathway silences selfish genetic elements in the germline.
Science (New York, N.Y.) Jul, 2006 | Pubmed ID: 16809489
Designing siRNA that distinguish between genes that differ by a single nucleotide.
PLoS genetics Sep, 2006 | Pubmed ID: 16965178
RNA interference: big applause for silencing in Stockholm.
Cell Dec, 2006 | Pubmed ID: 17174883
RNA silencing: genomic defence with a slice of pi.
Nature Apr, 2007 | Pubmed ID: 17443172
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.
Current biology : CB Jul, 2007 | Pubmed ID: 17604629
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.
Cell Jul, 2007 | Pubmed ID: 17662943
Sorting of Drosophila small silencing RNAs.
Cell Jul, 2007 | Pubmed ID: 17662944
Beginning to understand microRNA function.
Cell research Aug, 2007 | Pubmed ID: 17694094
Small silencing RNAs.
Current biology : CB Sep, 2007 | Pubmed ID: 17878043
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies.
Current biology : CB Jan, 2008 | Pubmed ID: 18207740
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells.
Science (New York, N.Y.) May, 2008 | Pubmed ID: 18403677
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells.
Nature protocols , 2008 | Pubmed ID: 18802435
Linking SNPs to CAG repeat length in Huntington's disease patients.
Nature methods Nov, 2008 | Pubmed ID: 18931668
Small silencing RNAs: an expanding universe.
Nature reviews. Genetics Feb, 2009 | Pubmed ID: 19148191
Nucleus and gene expression.
Current opinion in cell biology Jun, 2009 | Pubmed ID: 19447016
A role for microRNAs in the Drosophila circadian clock.
Genes & development Sep, 2009 | Pubmed ID: 19696147
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters.
Cell Sep, 2009 | Pubmed ID: 19732946
Huntington's disease: silencing a brutal killer.
Experimental neurology Dec, 2009 | Pubmed ID: 19786020
SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle.
Cell Oct, 2009 | Pubmed ID: 19879848
SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle.
Cell Nov, 2009 | Pubmed ID: 19914174
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway.
RNA (New York, N.Y.) Jan, 2010 | Pubmed ID: 19917635
Welcome to silence.
Silence , 2010 | Pubmed ID: 20226068
Target RNA-directed trimming and tailing of small silencing RNAs.
Science (New York, N.Y.) Jun, 2010 | Pubmed ID: 20558712
Somatic piRNA biogenesis.
The EMBO journal Oct, 2010 | Pubmed ID: 20924396
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins.
RNA (New York, N.Y.) Jan, 2011 | Pubmed ID: 21106652
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.
Genome research Feb, 2011 | Pubmed ID: 21177969
MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2011 | Pubmed ID: 21179009
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.
Cell Dec, 2010 | Pubmed ID: 21183072
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.
Molecular cell Apr, 2011 | Pubmed ID: 21419681
A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation.
Silence , 2011 | Pubmed ID: 21649885
Argonaute proteins.
Current biology : CB Jun, 2011 | Pubmed ID: 21683893
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.
RNA (New York, N.Y.) Oct, 2011 | Pubmed ID: 21878547
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1.
Current biology : CB Nov, 2011 | Pubmed ID: 22055293
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains.
Molecular cell Nov, 2011 | Pubmed ID: 22099305
Adaptation to P element transposon invasion in Drosophila melanogaster.
Cell Dec, 2011 | Pubmed ID: 22196730
Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2012 | Pubmed ID: 22252449
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