Graduate School of Medical Science and Engineering,
KI for Health Science and Technology
Dr. Pilhan Kim is an Associate Professor of Graduate School of Medical Science and Engineering (GSMSE) at Korea Advanced Institute of Science and Technology (KAIST). He received B.S. and Ph. D. degree in Electrical Engineering from Seoul National University, Korea, in 2000 and 2005, respectively. From 2005 to 2010, he worked as a postdoctoral research fellow at Harvard Medical School, Massachusetts General Hospital Boston, USA, with the cross-disciplinary postdoctoral fellowship from Human Frontier Science Program (HFSP). At 2010, he joined KAIST as a tenure-track faculty and was appointed as a tenured Associate Professor at 2018.
His main research interest is the development of advanced state-of-arts in vivo cellular imaging technology based on a custom-built real-time laser-scanning intravital confocal and two-photon microscopy. Utilizing the image system, his group have achieved a systemic cellular-level visualization of various preclinical animal model to investigate the complex pathophysiology of human diseases and develop novel therapeutics.
Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals.
Nature protocols Jul, 2012 | Pubmed ID: 22767088
Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts.
Circulation research Mar, 2013 | Pubmed ID: 23392842
In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes.
Journal of biomedical optics Mar, 2013 | Pubmed ID: 23462969
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
The Journal of clinical investigation Sep, 2014 | Pubmed ID: 25061877
Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells.
Hepatology (Baltimore, Md.) Jun, 2015 | Pubmed ID: 25627085
Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis.
Theranostics , 2015 | Pubmed ID: 25897337
In vivo quantitation of injected circulating tumor cells from great saphenous vein based on video-rate confocal microscopy.
Biomedical optics express Jun, 2015 | Pubmed ID: 26114035
Intravital imaging of intestinal lacteals unveils lipid drainage through contractility.
The Journal of clinical investigation Nov, 2015 | Pubmed ID: 26436648
Identification of cromolyn sodium as an anti-fibrotic agent targeting both hepatocytes and hepatic stellate cells.
Pharmacological research Dec, 2015 | Pubmed ID: 26453959
In vivo longitudinal cellular imaging of small intestine by side-view endomicroscopy.
Biomedical optics express Oct, 2015 | Pubmed ID: 26504646
Optical clearing based cellular-level 3D visualization of intact lymph node cortex.
Biomedical optics express Oct, 2015 | Pubmed ID: 26504662
Urokinase exerts antimetastatic effects by dissociating clusters of circulating tumor cells.
Cancer research Nov, 2015 | Pubmed ID: 26527605
Amelioration of sepsis by TIE2 activation-induced vascular protection.
Science translational medicine 04, 2016 | Pubmed ID: 27099174
Corrigendum to "Identification of cromolyn sodium as an anti-fibrotic agent targeting both hepatocytes and hepatic stellate cells" [Pharmacol. Res. 102 (2015) 176-183].
Pharmacological research Aug, 2016 | Pubmed ID: 27137797
In Vivo Fluorescence Retinal Imaging Following AAV2-Mediated Gene Delivery in the Rat Retina.
Investigative ophthalmology & visual science 06, 2016 | Pubmed ID: 27367507
Imaging Laser-Induced Choroidal Neovascularization in the Rodent Retina Using Optical Coherence Tomography Angiography.
Investigative ophthalmology & visual science Jul, 2016 | Pubmed ID: 27409490
Holographic intravital microscopy for 2-D and 3-D imaging intact circulating blood cells in microcapillaries of live mice.
Scientific reports 09, 2016 | Pubmed ID: 27605489
Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection.
Nature microbiology 10, 2016 | Pubmed ID: 27748732
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.
JCI insight 02, 2017 | Pubmed ID: 28194443
VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.
EMBO molecular medicine 06, 2017 | Pubmed ID: 28438786
Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells.
The Journal of cell biology 07, 2017 | Pubmed ID: 28611052
cellular-level real-time pharmacokinetic imaging of free-form and liposomal indocyanine green in liver.
Biomedical optics express Oct, 2017 | Pubmed ID: 29082096
Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclear-cytoplasmic labeling.
PloS one , 2017 | Pubmed ID: 29099870
Highly Angiogenic, Nonthrombogenic Bone Marrow Mononuclear Cell-Derived Spheroids in Intraportal Islet Transplantation.
Diabetes 03, 2018 | Pubmed ID: 29298810
Effect of resveratrol treatment on graft revascularization after islet transplantation in streptozotocin-induced diabetic mice.
Islets 01, 2018 | Pubmed ID: 29333922
Intravital imaging of a pulmonary endothelial surface layer in a murine sepsis model.
Biomedical optics express May, 2018 | Pubmed ID: 29760995
Quantitative two-photon microscopy imaging analysis of human skin to evaluate enhanced transdermal delivery by hybrid-type multi-lamellar nanostructure.
Biomedical optics express Aug, 2018 | Pubmed ID: 30338168
Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins.
Small (Weinheim an der Bergstrasse, Germany) 12, 2018 | Pubmed ID: 30411856
Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury.
The European respiratory journal 03, 2019 | Pubmed ID: 30635296
Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration.
Science advances 02, 2019 | Pubmed ID: 30788433
A Novel Pancreatic Imaging Window for Stabilized Longitudinal Observation of Pancreatic Islets in Murine Model.
Diabetes & metabolism journal 02, 2020 | Pubmed ID: 31237131
longitudinal depth-wise visualization of tumorigenesis by needle-shaped side-view confocal endomicroscopy.
Biomedical optics express Jun, 2019 | Pubmed ID: 31259046
3D cellular visualization of intact mouse tooth using optical clearing without decalcification.
International journal of oral science 08, 2019 | Pubmed ID: 31451694
PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice.
Journal of immunology research , 2019 | Pubmed ID: 31871955
Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis.
Circulation research 03, 2020 | Pubmed ID: 32078435
Micromirror-Embedded Coverslip Assembly for Bidirectional Microscopic Imaging.
Micromachines Jun, 2020 | Pubmed ID: 32532128
In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography.
Scientific reports 07, 2020 | Pubmed ID: 32733052
Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes.
Translational vision science & technology 05, 2020 | Pubmed ID: 32821517
longitudinal visualization of the brain neuroinflammatory response at the cellular level in LysM-GFP mice induced by 3-nitropropionic acid.
Biomedical optics express Aug, 2020 | Pubmed ID: 32923081
Intravital longitudinal imaging of hepatic lipid droplet accumulation in a murine model for nonalcoholic fatty liver disease.
Biomedical optics express Sep, 2020 | Pubmed ID: 33014604
Quantitative two-photon microscopy imaging analysis of human skin to evaluate enhanced transdermal delivery by hybrid-type multi-lamellar nanostructure: retraction.
Biomedical optics express Oct, 2020 | Pubmed ID: 33149992
Development and evaluation of an ultrasound-triggered microbubble combined transarterial chemoembolization (TACE) formulation on rabbit VX2 liver cancer model.
Theranostics , 2021 | Pubmed ID: 33391462
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