Rekha G. Panchal

Release of mitochondrial Ca2+ via the permeability transition activates endoplasmic reticulum Ca2+ uptake.

Pore formation is not associated with macroscopic redistribution of P2X7 receptors.

Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.

P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region.

Molecular mechanisms of filovirus cellular trafficking.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.

Identification of small molecule inhibitors of anthrax lethal factor.

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity.

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.

Analysis of Ebola virus and VLP release using an immunocapture assay.

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

Functional reconstitution of protein ion channels into planar polymerizable phospholipid membranes.

Anthrax biosensor, protective antigen ion channel asymmetric blockade.

Antisense treatments for biothreat agents.

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization.

Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival.

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis.

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.

Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents.

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols).

Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages.

Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.

Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.

Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection.

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.

Development of high-content imaging assays for lethal viral pathogens.

The rapidly advancing field of biodefense benefits many other, critical public health concerns.

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

Identification of a small-molecule entry inhibitor for filoviruses.

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor.

Shedding light on filovirus infection with high-content imaging.

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection.

Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for yersinia pestis infection.

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents.

Characterization of the Burkholderia thailandensis SOS response by using whole-transcriptome shotgun sequencing.

Anthrax toxin-induced rupture of artificial lipid bilayer membranes.

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns.

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Induced IL-10 splice altering approach to antiviral drug discovery.

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

Applications of In Vivo Imaging in the Evaluation of the Pathophysiology of Viral and Bacterial Infections and in Development of Countermeasures to BSL3/4 Pathogens.

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names.