Ronit Satchi-Fainaro

Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation.

Targeting tumor vasculature: reality or a dream?

PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combination.

Inhibition of angiogenesis by THAM-derived cotelomers endowed with thalidomide moieties.

Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470.

Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.

A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity.

The route of lipid administration affects parenteral nutrition-induced hepatic steatosis in a mouse model.

A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy.

Polymer therapeutics--polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities.

Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier.

Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer.

Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.

In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3.

In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin alpha v beta 3.

A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain.

Targeting bone metastases with a bispecific anticancer and antiangiogenic polymer-alendronate-taxane conjugate.

Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics.

Enhanced cytotoxicity of a polymer-drug conjugate with triple payload of paclitaxel.

Design and development of polymer conjugates as anti-angiogenic agents.

Real-time monitoring of drug release.

In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers.

Toward development of targeted nonsteroidal antiandrogen-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-gadolinium complex for prostate cancer diagnostics.

Novel folated and non-folated pullulan bioconjugates for anticancer drug delivery.

Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel.

Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances.

siRNA transfection by dendritic core-shell nanocarriers.

Antiangiogenic antitumor activity of HPMA copolymer-paclitaxel-alendronate conjugate on breast cancer bone metastasis mouse model.

Dendritic poly(ethylene glycol) bearing paclitaxel and alendronate for targeting bone neoplasms.

A unique paradigm for a Turn-ON near-infrared cyanine-based probe: noninvasive intravital optical imaging of hydrogen peroxide.

Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent.

Administration, distribution, metabolism and elimination of polymer therapeutics.

6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes.

Tumor-initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs.

Prospective identification of glioblastoma cells generating dormant tumors.

Hormonal regulation of pigment epithelium-derived factor (PEDF) in granulosa cells.

Porfimer-sodium (Photofrin-II) in combination with ionizing radiation inhibits tumor-initiating cell proliferation and improves glioblastoma treatment efficacy.

Poly(ethylene glycol)-paclitaxel-alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases.

Nano-sized polymers and liposomes designed to deliver combination therapy for cancer.

Synthesis and use of QCy7-derived modular probes for the detection and imaging of biologically relevant analytes.

Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release.

Interfering cancer with polymeric siRNA nanomedicines.

Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action.

Anticancer polymeric nanomedicine bearing synergistic drug combination is superior to a mixture of individually-conjugated drugs.

Protein Phosphatase Magnesium Dependent 1A Governs the Wound Healing-Inflammation-Angiogenesis Cross Talk on Injury.