Bruno Kyewski

Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes.

Bone marrow as a priming site for T-cell responses to blood-borne antigen.

Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.

CREB function is required for normal thymic cellularity and post-irradiation recovery.

Self-representation in the thymus: an extended view.

Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory.

Regulating self-tolerance by deregulating gene expression.

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels.

Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire.

Linking signalling pathways, thymic stroma integrity and autoimmunity.

Conflicts of interest: the responsibility of the authors and editors of the International Journal of Cancer.

A central role for central tolerance.

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage.

Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues.

Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity.

Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy.

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.

Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism.

How promiscuity promotes tolerance: the case of myasthenia gravis.

Immunology. A breath of Aire for the periphery.

The thymus medulla slowly yields its secrets.

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer.

Obligation for cell line authentication: appeal for concerted action.

Antigen presentation in the thymus for positive selection and central tolerance induction.

Aire, master of many trades.

Chronic inflammation is regarded as a strong promoter of tumorigenesis.

How thymic antigen presenting cells sample the body's self-antigens.

Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells.

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.

Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.

DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues.

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

The classical dichotomy between presentation of endogenous antigens via the MHC class I pathway and exogenous antigens via the MHC class-II pathway.

An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression.

An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression.

Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity.

Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).

Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.

Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.

Love is in the Aire: mTECs share their assets.

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.

Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.

Materno-fetal transfer of preproinsulin through the neonatal Fc receptor prevents autoimmune diabetes.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.