Division of Developmental Immunology
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Promiscuous gene expression and central T-cell tolerance: more than meets the eye.
Trends in immunology Jul, 2002 | Pubmed ID: 12103357
Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes.
The Journal of experimental medicine Feb, 2003 | Pubmed ID: 12566411
Bone marrow as a priming site for T-cell responses to blood-borne antigen.
Nature medicine Sep, 2003 | Pubmed ID: 12910264
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.
The Journal of experimental medicine Jan, 2004 | Pubmed ID: 14734521
CREB function is required for normal thymic cellularity and post-irradiation recovery.
European journal of immunology Jul, 2004 | Pubmed ID: 15214044
Self-representation in the thymus: an extended view.
Nature reviews. Immunology Sep, 2004 | Pubmed ID: 15343368
Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory.
International journal of oncology Oct, 2004 | Pubmed ID: 15375534
Regulating self-tolerance by deregulating gene expression.
Current opinion in immunology Dec, 2004 | Pubmed ID: 15511667
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels.
The Journal of experimental medicine Jul, 2005 | Pubmed ID: 15983066
Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire.
Cancer research Jul, 2005 | Pubmed ID: 16024649
Linking signalling pathways, thymic stroma integrity and autoimmunity.
Trends in immunology Oct, 2005 | Pubmed ID: 16039157
Conflicts of interest: the responsibility of the authors and editors of the International Journal of Cancer.
International journal of cancer. Journal international du cancer Jun, 2006 | Pubmed ID: 16482565
A central role for central tolerance.
Annual review of immunology , 2006 | Pubmed ID: 16551260
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage.
Proceedings of the National Academy of Sciences of the United States of America May, 2006 | Pubmed ID: 16709665
Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues.
Immunology letters Aug, 2006 | Pubmed ID: 16876259
Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity.
European journal of immunology Mar, 2007 | Pubmed ID: 17323415
Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy.
Cancer research Apr, 2007 | Pubmed ID: 17440107
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.
Nature Aug, 2007 | Pubmed ID: 17687331
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.
European journal of immunology Dec, 2007 | Pubmed ID: 18000951
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18180458
How promiscuity promotes tolerance: the case of myasthenia gravis.
Annals of the New York Academy of Sciences , 2008 | Pubmed ID: 18567865
Immunology. A breath of Aire for the periphery.
Science (New York, N.Y.) Aug, 2008 | Pubmed ID: 18687943
The thymus medulla slowly yields its secrets.
Annals of the New York Academy of Sciences Nov, 2008 | Pubmed ID: 19076347
The thymic medulla: a unique microenvironment for intercellular self-antigen transfer.
The Journal of experimental medicine Jul, 2009 | Pubmed ID: 19564355
Obligation for cell line authentication: appeal for concerted action.
International journal of cancer. Journal international du cancer Jan, 2010 | Pubmed ID: 19882693
Antigen presentation in the thymus for positive selection and central tolerance induction.
Nature reviews. Immunology Dec, 2009 | Pubmed ID: 19935803
Aire, master of many trades.
Cell Jan, 2010 | Pubmed ID: 20085700
Chronic inflammation is regarded as a strong promoter of tumorigenesis.
International journal of cancer. Journal international du cancer Aug, 2010 | Pubmed ID: 20564540
How thymic antigen presenting cells sample the body's self-antigens.
Current opinion in immunology Oct, 2010 | Pubmed ID: 20832274
Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 20966351
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
Blood Apr, 2011 | Pubmed ID: 21372153
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.
The Journal of clinical investigation Apr, 2011 | Pubmed ID: 21436590
Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.
Human molecular genetics Sep, 2011 | Pubmed ID: 21642385
DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues.
Molecular immunology Dec, 2011 | Pubmed ID: 22036612
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.
Nature immunology Feb, 2012 | Pubmed ID: 22179202
The classical dichotomy between presentation of endogenous antigens via the MHC class I pathway and exogenous antigens via the MHC class-II pathway.
Current opinion in immunology Feb, 2012 | Pubmed ID: 22305303
An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2013 | Pubmed ID: 23269248
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression.
European journal of immunology Jul, 2013 | Pubmed ID: 23589212
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2013 | Pubmed ID: 23980163
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).
Nature reviews. Immunology Jun, 2014 | Pubmed ID: 24830344
Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.
European journal of immunology Sep, 2014 | Pubmed ID: 24846220
Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.
Immunity Aug, 2014 | Pubmed ID: 25148026
Love is in the Aire: mTECs share their assets.
Immunity Sep, 2014 | Pubmed ID: 25238088
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2015 | Pubmed ID: 25552543
Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.
Journal of autoimmunity Jun, 2015 | Pubmed ID: 25911201
Materno-fetal transfer of preproinsulin through the neonatal Fc receptor prevents autoimmune diabetes.
Diabetes Apr, 2015 | Pubmed ID: 25918233
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.
Immunity Jun, 2015 | Pubmed ID: 26070482
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