Julia Calzada-Wack

Unbalanced overexpression of the mutant allele in murine Patched mutants.

Analysis of the PTCH coding region in human rhabdomyosarcoma.

Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis.

Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events.

Molecular characterization of Patched-associated rhabdomyosarcoma.

Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcoma.

Introducing the German Mouse Clinic: open access platform for standardized phenotyping.

A comprehensive antibody panel for immunohistochemical analysis of formalin-fixed, paraffin-embedded hematopoietic neoplasms of mice: analysis of mouse specific and human antibodies cross-reactive with murine tissue.

Systemic first-line phenotyping.

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.

Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse.

Allelic loss of chromosomes 8 and 19 in MENX-associated rat pheochromocytoma.

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.

Formalin-fixed paraffin-embedded (FFPE) proteome analysis using gel-free and gel-based proteomics.

Mouse phenotyping.

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation.

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation.

New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system.

Differences in the susceptibility to iodine¹³¹-induced thyroid tumours amongst inbred mouse strains.

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.

Innovations in phenotyping of mouse models in the German Mouse Clinic.

DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma.

An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease.

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.

MiR-34a deficiency accelerates medulloblastoma formation in vivo.

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.