Judy Lieberman

HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

Engineered Listeria monocytogenes as an AIDS vaccine.

siRNA-directed inhibition of HIV-1 infection.

Avoiding the kiss of death: how HIV and other chronic viruses survive.

Defying death--HIV mutation to evade cytotoxic T lymphocytes.

Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.

The functional CD8 T cell response to HIV becomes type-specific in progressive disease.

HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

RNA interference targeting Fas protects mice from fulminant hepatitis.

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.

The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells.

A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen.

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal.

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.

Interfering with disease: opportunities and roadblocks to harnessing RNA interference.

Nuclear war: the granzyme A-bomb.

Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach.

Public health. A sound rationale needed for phase III HIV-1 vaccine trials.

Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function.

Tracking the killers: how should we measure CD8 T cells in HIV infection?

Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function.

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.

Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors.

The silent revolution: RNA interference as basic biology, research tool, and therapeutic.

Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32.

The prospect of silencing disease using RNA interference.

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis.

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.

Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis.

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.

Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion.

Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation.

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis.

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair.

Your health in the 21st century. Silencing bad genes.

Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.

Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism.

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs.

Silencing viral infection.

Knocking down disease with siRNAs.

NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site.

Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.

Delivering the kiss of death: progress on understanding how perforin works.

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.

Interfering with disease: a progress report on siRNA-based therapeutics.

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys.

let-7 regulates self renewal and tumorigenicity of breast cancer cells.

Identification of host proteins required for HIV infection through a functional genomic screen.

Death by a thousand cuts: granzyme pathways of programmed cell death.

p16(INK4a) translation suppressed by miR-24.

RNA interference and cancer: endogenous pathways and therapeutic approaches.

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.

Whither or wither microbicides?

Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

RIG-ing an antitumor response.

Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.

The SET complex acts as a barrier to autointegration of HIV-1.

miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.

Harvard's women four years later.

Micromanagers of immune cell fate and function.

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.

Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry.

Micromanipulating cancer: microRNA-based therapeutics?

miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53.

miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.

miR-200 enhances mouse breast cancer cell colonization to form distant metastases.

Micromanaging cancer.

Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.

Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.

Small RNAs guide hematopoietic cell differentiation and function.

Isolation of cytotoxic T cell and NK granules and purification of their effector proteins.

Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets.

Granzyme A activates another way to die.

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.

Desperately seeking microRNA targets.

Promise and challenge of RNA interference-based therapy for cancer.

Gaining a foothold: how HIV avoids innate immune recognition.

Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV.

HIV DNA is heavily uracilated, which protects it from autointegration.

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras.

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.

Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.

Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs.

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling.

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis.

Alterations in RNA processing during immune-mediated programmed cell death.

SAMHD1 does it again, now in resting T cells.

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.

Efficient and specific gene knockdown by small interfering RNAs produced in bacteria.

Micromanaging hepatitis C virus.

Live or let die: posttranscriptional gene regulation in cell stress and cell death.

Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras.

Noncoding RNAs and cancer.

A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

Production of highly potent recombinant siRNAs in Escherichia coli.

Distribution of immune cells in the human cervix and implications for HIV transmission.

Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins.

Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer.

Perforin: a key pore-forming protein for immune control of viruses and cancer.

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus.

Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522.

miR-200-containing extracellular vesicles promote breast cancer cell metastasis.

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments.

Dysregulation of microRNA biogenesis and gene silencing in cancer.

Harnessing RNA interference for therapy: the silent treatment.

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.

Ex vivo cytosolic delivery of functional macromolecules to immune cells.

Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2.

An RNA-binding protein, Lin28, recognizes and remodels G-quartets in the miRNAs and mRNAs it regulates.