Judy Lieberman

Cellular and Molecular Medicine Program, Boston Children’s Hospital and Harvard Medical School

Affiliated withBoston Children’s Hospital and Harvard Medical School

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2015

Other Publications

Article	Year
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Molecular and cellular biology\| PubMed ID: 11909973	2002
Engineered Listeria monocytogenes as an AIDS vaccine. Vaccine\| PubMed ID: 11983264	2002
siRNA-directed inhibition of HIV-1 infection. Nature medicine\| PubMed ID: 12042777	2002
Avoiding the kiss of death: how HIV and other chronic viruses survive. Current opinion in immunology\| PubMed ID: 12088683	2002
Defying death--HIV mutation to evade cytotoxic T lymphocytes. The New England journal of medicine\| PubMed ID: 12374884	2002
Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood\| PubMed ID: 12393740	2003
The functional CD8 T cell response to HIV becomes type-specific in progressive disease. The Journal of clinical investigation\| PubMed ID: 12417573	2002
HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. The Journal of biological chemistry\| PubMed ID: 12421812	2003
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nature immunology\| PubMed ID: 12524539	2003
RNA interference targeting Fas protects mice from fulminant hepatitis. Nature medicine\| PubMed ID: 12579197	2003
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell\| PubMed ID: 12628186	2003
The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12682239	2003
A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12740437	2003
The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nature reviews. Immunology\| PubMed ID: 12766758	2003
Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. Journal of virology\| PubMed ID: 12805416	2003
Interfering with disease: opportunities and roadblocks to harnessing RNA interference. Trends in molecular medicine\| PubMed ID: 13129706	2003
Nuclear war: the granzyme A-bomb. Current opinion in immunology\| PubMed ID: 14499264	2003
Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach. Vaccine\| PubMed ID: 14505932	2003
Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science (New York, N.Y.)\| PubMed ID: 14726576	2004
Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS (London, England)\| PubMed ID: 15090765	2004
Tracking the killers: how should we measure CD8 T cells in HIV infection? AIDS (London, England)\| PubMed ID: 15238766	2004
Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function. Immunology\| PubMed ID: 15270723	2004
Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15466709	2004
Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 15602120	2004
The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annual review of medicine\| PubMed ID: 15660519	2005
Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32. Journal of virology\| PubMed ID: 15681448	2005
The prospect of silencing disease using RNA interference. JAMA\| PubMed ID: 15769970	2005
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity\| PubMed ID: 15780992	2005
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood\| PubMed ID: 15831707	2005
Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15843543	2005
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nature biotechnology\| PubMed ID: 15908939	2005
Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion. Journal of virology\| PubMed ID: 15919891	2005
Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15972676	2005
Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity\| PubMed ID: 16169498	2005
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature\| PubMed ID: 16299494	2006
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature\| PubMed ID: 16306938	2006
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Molecular cell\| PubMed ID: 16310392	2005
Your health in the 21st century. Silencing bad genes. Newsweek\| PubMed ID: 16375146	2005
Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO reports\| PubMed ID: 16440001	2006
Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16585504	2006
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Molecular cell\| PubMed ID: 16818237	2006
Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annual review of biomedical engineering\| PubMed ID: 16834561	2006
Silencing viral infection. PLoS medicine\| PubMed ID: 16848617	2006
Knocking down disease with siRNAs. Cell\| PubMed ID: 16873051	2006
NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site. PLoS pathogens\| PubMed ID: 17173480	2006
Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360483	2007
Delivering the kiss of death: progress on understanding how perforin works. Current opinion in immunology\| PubMed ID: 17433871	2007
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 17440703	2007
Interfering with disease: a progress report on siRNA-based therapeutics. Nature reviews. Drug discovery\| PubMed ID: 17541417	2007
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nature genetics\| PubMed ID: 17660818	2007
Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys. Vaccine\| PubMed ID: 17854955	2007
let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell\| PubMed ID: 18083101	2007
Identification of host proteins required for HIV infection through a functional genomic screen. Science (New York, N.Y.)\| PubMed ID: 18187620	2008
Death by a thousand cuts: granzyme pathways of programmed cell death. Annual review of immunology\| PubMed ID: 18304003	2008
p16(INK4a) translation suppressed by miR-24. PloS one\| PubMed ID: 18365017	2008
RNA interference and cancer: endogenous pathways and therapeutic approaches. Advances in experimental medicine and biology\| PubMed ID: 18437900	2008
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell\| PubMed ID: 18485875	2008
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Molecular cell\| PubMed ID: 18614045	2008
Whither or wither microbicides? Science (New York, N.Y.)\| PubMed ID: 18653884	2008
Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. Journal of virology\| PubMed ID: 18799576	2008
RIG-ing an antitumor response. Nature medicine\| PubMed ID: 18989278	2008
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell host & microbe\| PubMed ID: 19154990	2009
The SET complex acts as a barrier to autointegration of HIV-1. PLoS pathogens\| PubMed ID: 19266025	2009
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nature structural & molecular biology\| PubMed ID: 19377482	2009
Harvard's women four years later. Nature immunology\| PubMed ID: 19448653	2009
Micromanagers of immune cell fate and function. Advances in immunology\| PubMed ID: 19477322	2009
The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood\| PubMed ID: 19506301	2009
Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry. Journal of immunological methods\| PubMed ID: 19524586	2009
Micromanipulating cancer: microRNA-based therapeutics? RNA biology\| PubMed ID: 19535911	2009
miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood\| PubMed ID: 19584398	2009
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Molecular cell\| PubMed ID: 19748357	2009
miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PloS one\| PubMed ID: 19787069	2009
Micromanaging cancer. The New England journal of medicine\| PubMed ID: 19812408	2009
Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. The EMBO journal\| PubMed ID: 20019669	2010
Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood\| PubMed ID: 20038786	2010
Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20194725	2010
Small RNAs guide hematopoietic cell differentiation and function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20483778	2010
Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]\| PubMed ID: 20521234	2010
Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets. Immunological reviews\| PubMed ID: 20536551	2010
Granzyme A activates another way to die. Immunological reviews\| PubMed ID: 20536557	2010
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nature immunology\| PubMed ID: 20871604	2010
Desperately seeking microRNA targets. Nature structural & molecular biology\| PubMed ID: 20924405	2010
Promise and challenge of RNA interference-based therapy for cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 21079135	2011
Gaining a foothold: how HIV avoids innate immune recognition. Current opinion in immunology\| PubMed ID: 21123040	2011
Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HI... Journal of immune based therapies and vaccines\| PubMed ID: 21244649	2011
HIV DNA is heavily uracilated, which protects it from autointegration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21576478	2011
Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. The Journal of clinical investigation\| PubMed ID: 21576818	2011
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nature immunology\| PubMed ID: 21685908	2011
Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine\| PubMed ID: 21693155	2011
Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS genetics\| PubMed ID: 21935352	2011
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell\| PubMed ID: 22000013	2011
Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS genetics\| PubMed ID: 22102825	2011
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) pr... The Journal of biological chemistry\| PubMed ID: 22158624	2012
Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Science translational medicine\| PubMed ID: 22517885	2012
Alterations in RNA processing during immune-mediated programmed cell death. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22589304	2012
SAMHD1 does it again, now in resting T cells. Nature medicine\| PubMed ID: 23135508	2012
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nature immunology\| PubMed ID: 23263557	2013
Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nature biotechnology\| PubMed ID: 23475073	2013
Micromanaging hepatitis C virus. The New England journal of medicine\| PubMed ID: 23534545	2013
Live or let die: posttranscriptional gene regulation in cell stress and cell death. Immunological reviews\| PubMed ID: 23550650	2013
Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23629001	2013
Noncoding RNAs and cancer. Cell\| PubMed ID: 23781554	2013
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer cell\| PubMed ID: 23948298	2013
Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Molecular biology of the cell\| PubMed ID: 24088571	2013
Production of highly potent recombinant siRNAs in Escherichia coli. Nature protocols\| PubMed ID: 24177290	2013
Distribution of immune cells in the human cervix and implications for HIV transmission. American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 24410939	2014
Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24771851	2014
Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer research\| PubMed ID: 24786790	2014
Perforin: a key pore-forming protein for immune control of viruses and cancer. Sub-cellular biochemistry\| PubMed ID: 24798013	2014
Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell\| PubMed ID: 24906149	2014
Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell reports\| PubMed ID: 25088422	2014
Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. Cell reports\| PubMed ID: 25131211	2014
miR-200-containing extracellular vesicles promote breast cancer cell metastasis. The Journal of clinical investigation\| PubMed ID: 25401471	2014
G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25404306	2014
Dysregulation of microRNA biogenesis and gene silencing in cancer. Science signaling\| PubMed ID: 25783160	2015
Harnessing RNA interference for therapy: the silent treatment. JAMA\| PubMed ID: 25803342	2015
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell reports\| PubMed ID: 25818297	2015
Ex vivo cytosolic delivery of functional macromolecules to immune cells. PloS one\| PubMed ID: 25875117	2015
Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell reports\| PubMed ID: 25959823	2015
An RNA-binding protein, Lin28, recognizes and remodels G-quartets in the miRNAs and mRNAs it regulates. The Journal of biological chemistry\| PubMed ID: 26045559	2015