Chi-Hao Luan

Identification of the N-terminal functional domains of Cdk5 by molecular truncation and computer modeling.

Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.

Tethered dimers as NAD synthetase inhibitors with antibacterial activity.

Structural genomics for Caenorhabditis elegans: high throughput protein expression analysis.

High-throughput expression of C. elegans proteins.

Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases.

Protein production and crystallization at SECSG -- an overview.

Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library.

Improving solubility of Shewanella oneidensis MR-1 and Clostridium thermocellum JW-20 proteins expressed into Esherichia coli.

Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups.

Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins.

A high throughput platform for eukaryotic genes.

Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.

Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.

High-throughput screen for identifying small molecules that target fungal zinc homeostasis.

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.

Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.

Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential.

Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease.

Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics.

A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4.

Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila.

Ligand screening using fluorescence thermal shift analysis (FTS).

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.

Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.

Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons.

A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells.

Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity.

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2.

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.

Identification and characterization of PPARα ligands in the hippocampus.