High Throughput Analysis Laboratory,
Department of Molecular Biosciences,
High Throughput Analysis Laboratory, Department of Molecular Biosciences
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Identification of the N-terminal functional domains of Cdk5 by molecular truncation and computer modeling.
Proteins Aug, 2002 | Pubmed ID: 12112670
Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12221106
Tethered dimers as NAD synthetase inhibitors with antibacterial activity.
Journal of medicinal chemistry Jul, 2003 | Pubmed ID: 12852767
Structural genomics for Caenorhabditis elegans: high throughput protein expression analysis.
Protein expression and purification Mar, 2004 | Pubmed ID: 14766299
High-throughput expression of C. elegans proteins.
Genome research Oct, 2004 | Pubmed ID: 15489332
Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases.
Bioorganic & medicinal chemistry Jan, 2005 | Pubmed ID: 15582469
Protein production and crystallization at SECSG -- an overview.
Journal of structural and functional genomics , 2005 | Pubmed ID: 16211524
Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library.
Journal of combinatorial chemistry Nov-Dec, 2005 | Pubmed ID: 16283799
Improving solubility of Shewanella oneidensis MR-1 and Clostridium thermocellum JW-20 proteins expressed into Esherichia coli.
Journal of proteome research Nov-Dec, 2005 | Pubmed ID: 16335938
Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups.
Journal of medicinal chemistry May, 2007 | Pubmed ID: 17489580
Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins.
BMC biotechnology Jul, 2007 | Pubmed ID: 17663785
A high throughput platform for eukaryotic genes.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18542866
Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.
Bioorganic & medicinal chemistry May, 2010 | Pubmed ID: 20382537
Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Chemistry & biology Aug, 2011 | Pubmed ID: 21867918
High-throughput screen for identifying small molecules that target fungal zinc homeostasis.
PloS one , 2011 | Pubmed ID: 21980385
CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.
Nature communications , 2012 | Pubmed ID: 23093183
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer cell Nov, 2012 | Pubmed ID: 23153533
Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential.
Journal of virology Jun, 2013 | Pubmed ID: 23576501
Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease.
Journal of medicinal chemistry Jun, 2013 | Pubmed ID: 23651412
Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics.
Bioorganic & medicinal chemistry Jul, 2013 | Pubmed ID: 23688558
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4.
PloS one , 2013 | Pubmed ID: 24339940
Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila.
Journal of structural and functional genomics Mar, 2014 | Pubmed ID: 24562475
Ligand screening using fluorescence thermal shift analysis (FTS).
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24590724
Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.
PloS one , 2015 | Pubmed ID: 25928376
Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.
Journal of biomolecular screening Oct, 2015 | Pubmed ID: 26045196
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
Cell metabolism Aug, 2015 | Pubmed ID: 26118928
Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons.
Scientific reports Nov, 2015 | Pubmed ID: 26521685
A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells.
Cell reports Jan, 2016 | Pubmed ID: 26774481
Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity.
Journal of structural biology Apr, 2016 | Pubmed ID: 26796657
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
Nature communications Mar, 2016 | Pubmed ID: 26987594
Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2.
Data in brief Jun, 2016 | Pubmed ID: 27054155
Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.
The FEBS journal Jun, 2016 | Pubmed ID: 27101811
Identification and characterization of PPARα ligands in the hippocampus.
Nature chemical biology Oct, 2016 | Pubmed ID: 27748752
Ye Han*,1,
Kyle A. Lyman*,1,
Matt Clutter2,
Gary E. Schiltz3,
Quratul-Ain Ismail1,
Xiangying Cheng1,
Chi-Hao Luan4,
Dane M. Chetkovich1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University,
2Center for Molecular Innovation and Drug Discovery, Northwestern University,
3Department of Pharmacology, Feinberg School of Medicine, Northwestern University,
4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University,
5Department of Physiology, Feinberg School of Medicine, Northwestern University
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