Jacqueline Naylor

Sensing of lysophospholipids by TRPC5 calcium channel.

A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility.

TRPC channel activation by extracellular thioredoxin.

Robotic multiwell planar patch-clamp for native and primary mammalian cells.

Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.

Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids.

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan.

TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes.

Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels.

GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels.

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone.

Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands.

Generation of antibodies that are externally acting isoform-specific inhibitors of ion channels.

Use of the site-specific retargeting jump-in platform cell line to support biologic drug discovery.

Acoustic Dispensing Preserves the Potency of Therapeutic Peptides throughout the Entire Drug Discovery Workflow.

Natural and synthetic flavonoid modulation of TRPC5 channels.

Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists.