Steven Jacobson

Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP).

Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation.

Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient.

Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression.

Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats.

Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease.

Pathological and virological assessment of acute HTLV-I-associated myelopathy complicated with encephalopathy and systemic inflammation.

Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections.

Direct phenotypic analysis of human MHC class I antigen presentation: visualization, quantitation, and in situ detection of human viral epitopes using peptide-specific, MHC-restricted human recombinant antibodies.

High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection.

A novel multivalent human CTL peptide construct elicits robust cellular immune responses in HLA-A*0201 transgenic mice: implications for HTLV-1 vaccine design.

Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia.

Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+ CD25+ T Cells detected by peptide-specific, major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic disease.

Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis.

Quiescent phenotype of tumor-specific CD8+ T cells following immunization.

Immunopathogensis of HTLV-I associated neurologic disease: molecular, histopathologic, and immunologic approaches.

Protective efficacy of multiepitope human leukocyte antigen-A*0201 restricted cytotoxic T-lymphocyte peptide construct against challenge with human T-cell lymphotropic virus type 1 Tax recombinant vaccinia virus.

Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe.

Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.

Parkinsonism in the course of HTLV-I-associated myelopathy.

HPRT mutations, TCR gene rearrangements, and HTLV-1 integration sites define in vivo T-cell clonal lineages.

Interferon-beta1a therapy in human T-lymphotropic virus type I-associated neurologic disease.

International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials.

Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease.

CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion.

Human herpesvirus 6 and multiple sclerosis: potential mechanisms for virus-induced disease.

Differential tropism of human herpesvirus 6 (HHV-6) variants and induction of latency by HHV-6A in oligodendrocytes.

Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis.

Human T lymphotropic virus types I and II western blot seroindeterminate status and its association with exposure to prototype HTLV-I.

Differential HHV-6A gene expression in T cells and primary human astrocytes based on multi-virus array analysis.

Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease.

HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death.

Chimeric peptide vaccine composed of B- and T-cell epitopes of human T-cell leukemia virus type 1 induces humoral and cellular immune responses and reduces the proviral load in immunized squirrel monkeys (Saimiri sciureus).

Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways.

Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection.

Natural history of viral markers in children infected with human T lymphotropic virus type I in Jamaica.

Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells.

Efficacy of antiviral compounds in human herpesvirus-6-infected glial cells.

Natalizumab and immune cells.

Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells.

GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1.

Highlights from 5th International Conference on HHV-6 and -7.

Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid.

Detection of HHV-6B in post-mortem central nervous system tissue of a post-bone marrow transplant recipient: a multi-virus array analysis.

Association of human herpesvirus-6B with mesial temporal lobe epilepsy.

Purification of infectious human herpesvirus 6A virions and association of host cell proteins.

Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes.

Dysregulation of TGF-beta signaling and regulatory and effector T-cell function in virus-induced neuroinflammatory disease.

Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients.

Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease.

Surgical anatomy of the midcheek: facial layers, spaces, and the midcheek segments.

Human herpes virus 6B: a possible role in epilepsy?

Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy.

Anti-HTLV antibody profiling reveals an antibody signature for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Creating environment for cancer care.

Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis.

Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis.

Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas.

Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells.

Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder.

Summary of the 6th International Conference on HHV-6 and -7.

Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker.

High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.

Multistability in a model for CTL response to HTLV-I infection and its implications to HAM/TSP development and prevention.

Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques.

Neuroimmunity of HTLV-I Infection.

Viral infections of the central nervous system: pathogenesis to therapeutics.

Mechanism of neuroinflammation: enhanced cytotoxicity and IL-17 production via CD46 binding.

Review part 2: Human herpesvirus-6 in central nervous system diseases.

Translocator protein PET imaging for glial activation in multiple sclerosis.

TGF-β signaling is altered in the peripheral blood of subjects with multiple sclerosis.

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.

The NK cell as a new player in the pathogenesis of HTLV-I associated neurologic disease.

Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I-associated neurologic disease.

Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs.

Human herpesvirus-6 entry into the central nervous system through the olfactory pathway.

In vivo quantification of T₂ anisotropy in white matter fibers in marmoset monkeys.

Etiologies of rash and fever illnesses in Campinas, Brazil.

The prevalence and significance of HTLV-I/II seroindeterminate Western blot patterns.

Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease.

Mediastinal silicone lymphadenopathy secondary to a ruptured breast implant.

HTLV-I-associated myelopathy/tropical spastic paraparesis: semiautomatic quantification of spinal cord atrophy from 3-dimensional MR images.

Quantitative differences in HTLV-I antibody responses: classification and relative risk assessment for asymptomatic carriers and ATL and HAM/TSP patients from Jamaica.

Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease.

Translocator protein 18 kDa (TSPO) expression in multiple sclerosis patients.

Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization.

Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals.

Microvascular salvage of a thrombosed total ear replant.

Perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging.

Impact and outcome of human acellular dermal matrix size for immediate and two-stage breast reconstruction.

Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy.

Microbial biofilms and breast tissue expanders.

A systematic review of the use of Botulinum toxin type A with subpectoral breast implants.

Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization.

CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis.

Classification of HHV-6A and HHV-6B as distinct viruses.

Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstrated by novel digital droplet PCR assay.

In vivo immunogenicity of Tax(11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine.

Digital droplet PCR (ddPCR) for the precise quantification of human T-lymphotropic virus 1 proviral loads in peripheral blood and cerebrospinal fluid of HAM/TSP patients and identification of viral mutations.

Epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional suppression of Tregs.

Facelift complications related to median and peak blood pressure evaluation.

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.

Imaging Features of AlloDerm(®) Used in Postmastectomy Breast Reconstructions.

Intraoperative angiography provides objective assessment of skin perfusion in complex knee reconstruction.

In vivo imaging of spinal cord atrophy in neuroinflammatory diseases.

The formation of inflammatory demyelinated lesions in cerebral white matter.

Randomized trial of drain antisepsis after mastectomy and immediate prosthetic breast reconstruction.

Impact of reconstruction and reoperation on long-term patient-reported satisfaction after contralateral prophylactic mastectomy.

Inflammatory manifestations of HTLV-1 and their therapeutic options.

Co-dependence of HTLV-1 p12 and p8 functions in virus persistence.

Evidence linking HHV-6 with multiple sclerosis: an update.

Red breast syndrome: a review of available literature.

Introducing the SKIN score: a validated scoring system to assess severity of mastectomy skin flap necrosis.

The Chitranjan Ranawat Award: Running Subcuticular Closure Enables the Most Robust Perfusion After TKA: A Randomized Clinical Trial.

Human Herpesvirus 6 as a Viral Trigger in Mesial Temporal Lobe Epilepsy.

Abstract 99: reducing unplanned reoperations for mastectomy skin flap necrosis - a multidisciplinary approach.

Current strategies with 2-staged prosthetic breast reconstruction.

Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.

Expanded Indications and Improved Outcomes for Nipple-Sparing Mastectomy Over Time.

Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis.

Comparative Study of Liposomal Bupivacaine Versus Paravertebral Block for Pain Control Following Mastectomy with Immediate Tissue Expander Reconstruction.

Is the SMAS Flap Facelift Safe? A Comparison of Complications Between the Sub-SMAS Approach Versus the Subcutaneous Approach With or Without SMAS Plication in Aesthetic Rhytidectomy at an Academic Institution.

Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets.

Revisiting an Old Place: Single Surgeon Experience on Post-Mastectomy Subcutaneous Implant Based Breast Reconstruction.

Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans.

Use of immediate breast reconstruction and choice for contralateral prophylactic mastectomy.

Tailoring through Technology: A Retrospective Review of a Single Surgeon's Experience with Implant-Based Breast Reconstruction before and after Implementation of Laser-Assisted Indocyanine Green Angiography.

Dual-Energy CT for Evaluation of Intra- and Extracapsular Silicone Implant Rupture.

Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions.

Exosomes in Viral Disease.

Vaccinations for Neuroinfectious Disease: A Global Health Priority.

Editorial.

Cytokine Therapies in Neurological Disease.

Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls.

Development of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1).

Intrathecal T-cell clonal expansions in patients with multiple sclerosis.

Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.

Outcomes and feasibility of nipple-sparing mastectomy for node-positive breast cancer patients.

Dynamic acquisition of HTLV-1 tax protein by mononuclear phagocytes: Role in neurologic disease.

Reducing the global burden of HTLV-1 infection: An agenda for research and action.